Course Link Tool for Loosely Engaging Sakai CLE with Student Information SystemKyoto University
The current Site Setup Tool of Sakai CLE provides a way to create course sites for faculty based on the course/section information from Student Information System (SIS). However, it requires several steps to complete and it does not provide a way to let faculty know how many students are willing to use their course site. Also we think that course sites should be created by faculty's willingness to use, and course sites nobody uses should not be created. To assist this strategy, we have developed a new course site setup tool named "Course Link" tool to provide a lightweight linkage tool between Student Information System and Sakai CLE. The Course Link tool is implemented by using Entity Broker and assists faculty to create their course site easily. In our presentation, we will describe our experiences of this tool in 2014 first semester.
Course Link Tool for Loosely Engaging Sakai CLE with Student Information SystemKyoto University
The current Site Setup Tool of Sakai CLE provides a way to create course sites for faculty based on the course/section information from Student Information System (SIS). However, it requires several steps to complete and it does not provide a way to let faculty know how many students are willing to use their course site. Also we think that course sites should be created by faculty's willingness to use, and course sites nobody uses should not be created. To assist this strategy, we have developed a new course site setup tool named "Course Link" tool to provide a lightweight linkage tool between Student Information System and Sakai CLE. The Course Link tool is implemented by using Entity Broker and assists faculty to create their course site easily. In our presentation, we will describe our experiences of this tool in 2014 first semester.
Scholarship holder at MSc Petroleum Geo-Engineering program 2017/2018 of The Miskolc University MFK Faculty of Earth Science and Engineering
https://www.linkedin.com/in/emadnagehmasri
+36204122987
emad.n.masri@gmail.com
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Scholarship holder at MSc Petroleum Geo-Engineering program 2017/2018 of The Miskolc University MFK Faculty of Earth Science and Engineering
https://www.linkedin.com/in/emadnagehmasri
+36204122987
emad.n.masri@gmail.com
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
1. Mehrdad Sarhangi (CV)
MehrdadSarhangi@gmail.com
Pg.1
Phone: 00989141040209
1- Personal Information:
Full Name: Mehrdad Sarhangi
Passport No:
A34003715
Nationality:
Iranian
Place of Birth:
Malekan, Iran
Date of Birth: 30/06/1985
Marital Status : Single Gender:
Male
2- Education & Qualification:
Level Majored in
Duration Name of the school/university
/instituteFrom To
Doctor Geology, Tectonic 2015 yet
Department of Geology , Science and Research branch,
Islamic Azad University, Tehran, Iran
Master Geology, Tectonic 2009 2012
Department of Geology , Science and Research branch,
Islamic Azad University, Tehran, Iran
Bachelor Geology 2005 2009
Department of Geology, Islamic Azad University, Tabriz,
Iran
3- Experience Engineering
Issue Time Company/ Organization
Preparation of the National Atlas of
Geological Hazards
2020 Geological Survey of Iran
Preparation of tourism map and Atlas of
Piranshahr city of West Azerbaijan
province
2019
West Azerbaijan Cultural Heritage, Tourism &
Handicrafts, Tourism & Handicrafts administration
Preparation of tourism map and Atlas of
Sardasht city of West Azerbaijan province
2019
West Azerbaijan Cultural Heritage, Tourism &
Handicrafts, Tourism & Handicrafts administration
Preparation of tourism map and Atlas of
Naqadeh city of West Azerbaijan province
2019
West Azerbaijan Cultural Heritage, Tourism &
Handicrafts, Tourism & Handicrafts administration
Morphotectonic and Structural Analysis of the
Zendan Fault, South of Iran
2017-
2019
Iranian Offshore Oil Company (IOOC)
Preparation of Geotourism map of Sarein
Area
2018
Geographic Organization of Iran
Assessment of active tectonics and the effect
faults on military structures on the coast of the
Persian Gulf and Oman Sea.
2013
Geographic Organization of Iran
Internships 2011 Abrah Gustar Tadbir company
2. Mehrdad Sarhangi (CV)
MehrdadSarhangi@gmail.com
Pg.2
4- Skill & Work Experience:
Company/ Organization
Part time/
Full time/
Consultation
Duration
Position
Since To
Preparation of geological and
geotourism maps
Part 2016 yet Geographic Organization of Iran
The first International Exhibition
and Conference of Safety
,Security and Disaster
management in natural disasters
Part 2015 2017
Executive Committee & Scientific
management
Working Group on environmental
hazards at the Strategic Research
Center of the Iranian defense.
Part &
Consultation
2013 2016 Member
Association of Iranian Hazard Full-time 2012 yet
Office manager and
Member
Association of Iranian Hazard part 2015 2015
Executive Director of the Hazards
and low
Geographical Organization of
iran
part 2013 2014
Scientific secretary of the meeting to
predict earthquakes
Shahid Beheshti University part 2013 2013
Executive Secretary of the Scientific
Meeting of the nature and definition
of Hazard science
Geographical Organization of
iran
part 2013 2013
Executive Director of the
Scientific Meeting dust hazards
Geographical Organization of
iran
part 2014 2014
Science and executive secretary
of the scientific meeting earth
subsidence risk
5- Foreign Language Proficiency:
Foreign Language
Competence
(Reading, Writing and Speaking)
Azerbaijani Good
Persian Good
Turkish intermediate
English Elementary
3. Mehrdad Sarhangi (CV)
MehrdadSarhangi@gmail.com
Pg.3
6- Computer Skills:
Program Level
Word, Excel, Photoshop, illustrator Good
Arc GIS, Global Mapper, Google earth, Envi Good
Petrel, Geomatic, Stereo net, Basic
7- Other Educational Certificate:
Certificate Name of the Institute Place Year
Participation in the UNESCO
World Geoparks Workshop
UNESCO Qeshm, Iran 2018
The degree course Arc Envi
software from GSI
Geological Survey of
Iran
Tehran, Iran 2017
Certification workshop entitled”
Excursion to North Tabriz Fault and
Ahar-Varzeqan earthquake region”
on 19 February 2014
Geological Survey of
Iran
Tabriz, Iran 2014
The degree course Arc GIS
software from GSI
Geological Survey of
Iran
Tehran, Iran 2013
8- Publication Books:
Title
Year of
Publication
Name of the publication
Tourism Atlas of Sardasht County, West
Azerbaijan Province
2019 Geographic Organization of
Iran
Tourism Atlas of Piranshahr County, West
Azerbaijan Province
2019 Geographic Organization of
Iran
Tourism Atlas of Nagadeh County, West
Azerbaijan Province
2019 Geographic Organization of
Iran
Geotourism Atlas of Sarein Area 2018
Geographic Organization of
Iran
9- Publication Paper:
Title
Year of
Publication
Name of the publication
Assessment of active tectonics and quantification
of relative tectonic activity at Sufi - Chai basin in
south of Sahand volcano; northwest of Iran
2019
Iran's first national conference
on risk
Assessment of Quantitative Indices of Active
Tectonics and Quantification of Relative
Tectonic Activity at Mordaq-Chai Basin in South
of Sahand Volcano; Northwest of Iran
2015 Geological Survey of Iran
Assessment of active tectonics and quantification
of relative tectonic activity at Sufi - Chai basin in
south of Sahand volcano; northwest of Iran
2014
32nd National & the 1st
International Geosciences
Congress 2014