This document discusses female hair loss and an evidence-based approach to its diagnosis and management. It outlines four key steps: 1) Make an accurate diagnosis using history, exam findings including smartphone microscopy, and targeted labs; 2) Establish baselines using smartphone photos and hair mass measurement; 3) Choose an appropriate treatment; and 4) Manage treatment using measurable feedback like hair mass index. The diagnosis is usually thinning, shedding or breakage, determined by examining hair diameter, density and breakage patterns. Hair mass measurement provides an objective baseline and tool to monitor progress.
This document describes a new device called the trichometer that can precisely measure hair loss, growth, and damage by determining the cross-sectional area of a bundled hair sample. It aims to provide an objective measurement where current methods, like photography, cannot quantify hair amount. The trichometer addresses the need to measure both hair density and diameter to fully understand changes in hair quantity. Early prototypes compress hair bundles and measure the area with mechanical precision. Studies show bundle cross-sectional area strongly correlates with changes in hair properties like diameter and density, as well as dry weight. The trichometer could help physicians track treatment outcomes and further hair physiology research.
As more breakthroughs in the understanding of photomedicine and low level laser therapy occur, it is increasingly important for physicians to understand the role of low level laser therapy in the management of androgenetic alopecia (male and female pattern hair loss). This brief overview from the 19th Annual World Congress of Anti-Aging and Aesthetic medicine (A4M) in Orlando April 2011 followed Harvard/MIT professor, Dr. Michael Hamblin's detailed talk on the mechanisms of low level laser therapy.
This document summarizes a presentation on evidence-based hair loss management. It discusses the basics of hair loss and growth, including typical hair properties. It emphasizes the importance of evidence in medical treatment, highlighting FDA requirements to demonstrate efficacy, typically through measures of dry hair weight, hair density counts, photography, or patient surveys. These measures are discussed in detail. The presentation stresses that for effective management, hair loss must be measurable and that diameter changes can significantly impact hair mass more than density alone.
Depending on a number of critically important factors, hair transplant surgery can either be one of the best decisions you will ever make or among the worst
Criminal Detection by using Androgenic Hair PatternIRJET Journal
This document proposes a method for criminal identification using androgenic (body) hair patterns. It discusses how androgenic hair patterns are a stable biometric trait that can be used for identification even in low-resolution images. The proposed method uses Gabor filters to compute orientation fields of hair patterns. Histograms of orientations on a grid are used to describe local orientation patterns. Chi-square distance is used to measure differences between two samples. The method was found to be as effective as other surface recognition techniques such as local binary patterns and histograms of oriented gradients.
Hair transplantation is a surgical technique that removes hair follicles from one part of the body, called the 'donor site', to a bald or balding part of the body known as the 'recipient site'.
This document describes a new device called the trichometer that can precisely measure hair loss, growth, and damage by determining the cross-sectional area of a bundled hair sample. It aims to provide an objective measurement where current methods, like photography, cannot quantify hair amount. The trichometer addresses the need to measure both hair density and diameter to fully understand changes in hair quantity. Early prototypes compress hair bundles and measure the area with mechanical precision. Studies show bundle cross-sectional area strongly correlates with changes in hair properties like diameter and density, as well as dry weight. The trichometer could help physicians track treatment outcomes and further hair physiology research.
As more breakthroughs in the understanding of photomedicine and low level laser therapy occur, it is increasingly important for physicians to understand the role of low level laser therapy in the management of androgenetic alopecia (male and female pattern hair loss). This brief overview from the 19th Annual World Congress of Anti-Aging and Aesthetic medicine (A4M) in Orlando April 2011 followed Harvard/MIT professor, Dr. Michael Hamblin's detailed talk on the mechanisms of low level laser therapy.
This document summarizes a presentation on evidence-based hair loss management. It discusses the basics of hair loss and growth, including typical hair properties. It emphasizes the importance of evidence in medical treatment, highlighting FDA requirements to demonstrate efficacy, typically through measures of dry hair weight, hair density counts, photography, or patient surveys. These measures are discussed in detail. The presentation stresses that for effective management, hair loss must be measurable and that diameter changes can significantly impact hair mass more than density alone.
Depending on a number of critically important factors, hair transplant surgery can either be one of the best decisions you will ever make or among the worst
Criminal Detection by using Androgenic Hair PatternIRJET Journal
This document proposes a method for criminal identification using androgenic (body) hair patterns. It discusses how androgenic hair patterns are a stable biometric trait that can be used for identification even in low-resolution images. The proposed method uses Gabor filters to compute orientation fields of hair patterns. Histograms of orientations on a grid are used to describe local orientation patterns. Chi-square distance is used to measure differences between two samples. The method was found to be as effective as other surface recognition techniques such as local binary patterns and histograms of oriented gradients.
Hair transplantation is a surgical technique that removes hair follicles from one part of the body, called the 'donor site', to a bald or balding part of the body known as the 'recipient site'.
This document reviews follicular unit extraction (FUE) hair transplant techniques. It discusses how FUE addresses limitations of traditional strip surgery such as a visible linear scar. The FUE procedure involves using punch devices to extract individual follicular units from the donor area for transplantation. Variations include 2-step versus 3-step punch methods and automated versus manual extraction. Powered devices can decrease harvest time and graft transection rates compared to manual FUE. Overall, FUE is a minimally invasive option that avoids disadvantages of strip surgery like prolonged downtime and visible scarring.
The document describes a new device called the Hair Quantimeter that can precisely and accurately measure hair loss and growth. It measures both hair density and diameter within a small area of the scalp. This provides a quantitative Hair Quantity Index value that reflects changes in hair mass. The device could be used by physicians to track hair shedding and thinning, evaluate treatments, and identify early-stage hair loss. It offers advantages over current methods by generating objective numbers to diagnose, monitor, and determine treatment success for the multi-billion dollar hair loss industry.
Hair transplant surgery is a popular solution for individuals experiencing hair loss, as it involves the transfer of healthy hair follicles from one part of the scalp to another. In this guide, we will delve into the cost and process of hair transplant surgery, providing a comprehensive overview for those considering this procedure.
Hair Transplant Articles and Documents | Dr Tyng Tan | Hair and Laser ClinicThe Hair and Laser Clinic
Collection of hair transplantation articles and documents shared to you by Dr Tyng Tan of Hair and Laser Clinic (http://www.hairandlaserclinic.com/). A Singapore-based clinic specializing in FUE hair transplant and medical aesthetics.
This document summarizes various methods for temporary and permanent hair removal. Temporary methods include shaving, tweezing, bleaching, and depilatory creams. Permanent methods discussed are electrolysis, thermolysis, and laser/IPL treatments. Key factors for effective laser hair removal include appropriate wavelength and pulse duration based on skin and hair characteristics. Multiple treatments spaced 1-3 months apart are typically needed to achieve significant hair reduction. Potential side effects include pain, pigmentary changes, and infection if not performed properly. Permanent hair removal is difficult to achieve and regrowth may still occur.
1. The document discusses hair, its chemistry, tensile strength, and other factors. It summarizes that hair is composed of keratin protein and has a tensile strength of around 200 MPa.
2. It describes methods of measuring tensile strength using a tensometer and definitions of terms like stress and strain. Measurement results for various materials are shown with human hair having a tensile strength of 200 MPa.
3. The document discusses several hair myths and facts, such as shaving not affecting hair growth, conditioner not being able to repair split ends but improving appearance, and smoking being linked to gray hair. It also covers causes of hair loss like stress, medications, infections and treatments for hair
by KEN L. WILLIAMS, JR., DO
Hair restoration surgery has evolved into a scientifically based cosmetic surgical discipline over the last half century. A recent hair surgical technique to evolve, Follicular Unit Extraction (FUE), is a donor harvesting technique removing single “follicular units “one unit at a time” with a small round punch.
Hair Transplantation techniques have been evolving and becoming more effective. Among the various cosmetic surgeries, hair restoration has become very innovative. If you undertake this cosmetic surgery then the results would look more natural. It has become a very aesthetic and exciting surgery today. The way it uses hair follicles to restore hair is a unique invention of science. Latest methods like hair cloning are also researched on. This will help in hair multiplication and will also cure baldness with increased hair growth.
Methods and Material:
The two methods included in hair transplant surgery are: Follicular Unit Transplant and Follicular Unit Extraction. Each method has its own unique pros and cons. These methods are based on the doctrine of donor dominance. Some of the tests that are done include: serum chemistries and coagulation studies. Screening technology is also enabled to take follicular measurements.
Results:
Care after Operation:
Just like one should take precaution after any operation, similarly, after undergoing a hair transplant, you must take a number of precautions. Direct exposure to sunlight must be avoided. You must not fiddle with your hair for the first two days; however, shampoo can be done. You must be careful that post operation, scabs must not be formed around the hair shaft. There is also a phase called “shock-loss”. In this phase, newly planted hairs usually fall out. Nevertheless, new hair re-grows within 2 or 3 months. The growth process continues and thickens with time.
Discussions:
A patient takes up hair transplant only when he or she wants to get rid of baldness and hair thinning problems permanently. Nevertheless, it has been reported that hair thinning is also seen post this cosmetic surgery. It is also called “shock-loss”. This is an important side-effect seen after hair transplant surgery. Another common sight is the appearance of bald patches. An estimated amount of 50 hairs are usually lost each day. The temple and the scalp do often get swollen. Itching and Scratching must be refrained from as that can lead to scab formation.
Conclusion:
According to a recent study, papilla cells and stem cells have been found in the hair follicles. It can be used in correcting baldness with the help of hair multiplication. This method is also called hair cloning. Therefore, it can be concluded that the hair surgical technique has a long way to go. Those who want to opt for this surgery can browse through the internet to gain an in-depth knowledge about hair transplantation. Results have proved that pain is negligible and the recovery time also doesn’t protract. You do not need to be hospitalized nor is any bed rest required. Hair Transplant indeed is a viable choice and is rewarding.
Radiation therapy patient treatment planning & post treatment care new/ Labia...Indian dental academy
The document discusses dental care considerations for patients undergoing radiation therapy for head and neck cancers. It outlines that a dental examination should be performed before treatment to address any dental issues and reduce risks during and after radiation. Extractions should be completed 10-21 days before starting radiation to allow for healing. During radiation, dental care can help prevent oral complications like mucositis and xerostomia. Long term effects on the oral cavity are also discussed. The document emphasizes the importance of dental treatment planning and care coordination between dentists and oncologists for radiation therapy patients.
icometrix offers imaging biomarkers for anatomical MRI or CT images as well as for functional, diffusion and perfusion MR images.
Medical imaging serves as an endpoint in an increasing number of clinical trials for neurological disorders to evaluate the effectiveness of novel therapeutic options and to better understand the pathophysiology. It is critical to obtain objective imaging measurements.Therefore, the use of
high-quality MRI data and quantitative MRI biomarkers is also recommended in the latest guidelines of the European Medicine Agency on clinical investigation of medicinal products for treatment of dementia, multiple sclerosis and other neurological disorders.
Digital Health: Company presentation by Eyal Gura, Co-Founder & CEO of Zebra Medical Vision at the NOAH Conference London 2019, 30-31 October, Old Billingsgate.
Trace evidence such as hair and fibers found at a crime scene can provide important clues about what happened. Hair analysis can determine characteristics like the race of the source and whether drugs were ingested. Microscopic analysis of hair cuticle scale patterns, cortex pigment distribution, and medulla shape and index can indicate if a hair sample matches a suspect or victim. Fiber evidence can also connect a suspect to a crime scene based on the type of polymer and weave of the fiber. Together, hair and fiber evidence through microscopic analysis can help place a suspect at the scene of a crime.
Radiation therapy patient treatment planning & post treatment care newIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
MedicalResearch.com: Medical Research Exclusive Interviews December 14 2014Marie Benz MD FAAD
MedicalResearch.com features exclusive interviews with medical researchers from major and specialty medical research and health care journals and meetings.
Three key points from the document are:
1. Chemotherapy-induced hair loss occurs in approximately 65% of patients undergoing chemotherapy. Hair loss is one of the most traumatic aspects of chemotherapy for many patients.
2. Scalp cooling has been shown to be the most effective method for reducing chemotherapy-induced alopecia according to several clinical studies. One hospital in Northern California currently offers cold caps.
3. The document reviews 5 studies on scalp cooling that range from randomized controlled trials to qualitative studies. The studies show that scalp cooling significantly reduces the risk of chemotherapy-induced alopecia for most chemotherapy regimens.
This document discusses the role of low level laser therapy (LLLT) in the medical management of androgenetic alopecia. It provides an overview of androgenetic alopecia and the mechanisms by which LLLT may stimulate hair follicles. It then describes the author's LLLT dosing protocol and experience treating patients, showing before and after photos demonstrating hair growth with LLLT. The document concludes by referencing supporting literature on LLLT for hair loss.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
This document reviews follicular unit extraction (FUE) hair transplant techniques. It discusses how FUE addresses limitations of traditional strip surgery such as a visible linear scar. The FUE procedure involves using punch devices to extract individual follicular units from the donor area for transplantation. Variations include 2-step versus 3-step punch methods and automated versus manual extraction. Powered devices can decrease harvest time and graft transection rates compared to manual FUE. Overall, FUE is a minimally invasive option that avoids disadvantages of strip surgery like prolonged downtime and visible scarring.
The document describes a new device called the Hair Quantimeter that can precisely and accurately measure hair loss and growth. It measures both hair density and diameter within a small area of the scalp. This provides a quantitative Hair Quantity Index value that reflects changes in hair mass. The device could be used by physicians to track hair shedding and thinning, evaluate treatments, and identify early-stage hair loss. It offers advantages over current methods by generating objective numbers to diagnose, monitor, and determine treatment success for the multi-billion dollar hair loss industry.
Hair transplant surgery is a popular solution for individuals experiencing hair loss, as it involves the transfer of healthy hair follicles from one part of the scalp to another. In this guide, we will delve into the cost and process of hair transplant surgery, providing a comprehensive overview for those considering this procedure.
Hair Transplant Articles and Documents | Dr Tyng Tan | Hair and Laser ClinicThe Hair and Laser Clinic
Collection of hair transplantation articles and documents shared to you by Dr Tyng Tan of Hair and Laser Clinic (http://www.hairandlaserclinic.com/). A Singapore-based clinic specializing in FUE hair transplant and medical aesthetics.
This document summarizes various methods for temporary and permanent hair removal. Temporary methods include shaving, tweezing, bleaching, and depilatory creams. Permanent methods discussed are electrolysis, thermolysis, and laser/IPL treatments. Key factors for effective laser hair removal include appropriate wavelength and pulse duration based on skin and hair characteristics. Multiple treatments spaced 1-3 months apart are typically needed to achieve significant hair reduction. Potential side effects include pain, pigmentary changes, and infection if not performed properly. Permanent hair removal is difficult to achieve and regrowth may still occur.
1. The document discusses hair, its chemistry, tensile strength, and other factors. It summarizes that hair is composed of keratin protein and has a tensile strength of around 200 MPa.
2. It describes methods of measuring tensile strength using a tensometer and definitions of terms like stress and strain. Measurement results for various materials are shown with human hair having a tensile strength of 200 MPa.
3. The document discusses several hair myths and facts, such as shaving not affecting hair growth, conditioner not being able to repair split ends but improving appearance, and smoking being linked to gray hair. It also covers causes of hair loss like stress, medications, infections and treatments for hair
by KEN L. WILLIAMS, JR., DO
Hair restoration surgery has evolved into a scientifically based cosmetic surgical discipline over the last half century. A recent hair surgical technique to evolve, Follicular Unit Extraction (FUE), is a donor harvesting technique removing single “follicular units “one unit at a time” with a small round punch.
Hair Transplantation techniques have been evolving and becoming more effective. Among the various cosmetic surgeries, hair restoration has become very innovative. If you undertake this cosmetic surgery then the results would look more natural. It has become a very aesthetic and exciting surgery today. The way it uses hair follicles to restore hair is a unique invention of science. Latest methods like hair cloning are also researched on. This will help in hair multiplication and will also cure baldness with increased hair growth.
Methods and Material:
The two methods included in hair transplant surgery are: Follicular Unit Transplant and Follicular Unit Extraction. Each method has its own unique pros and cons. These methods are based on the doctrine of donor dominance. Some of the tests that are done include: serum chemistries and coagulation studies. Screening technology is also enabled to take follicular measurements.
Results:
Care after Operation:
Just like one should take precaution after any operation, similarly, after undergoing a hair transplant, you must take a number of precautions. Direct exposure to sunlight must be avoided. You must not fiddle with your hair for the first two days; however, shampoo can be done. You must be careful that post operation, scabs must not be formed around the hair shaft. There is also a phase called “shock-loss”. In this phase, newly planted hairs usually fall out. Nevertheless, new hair re-grows within 2 or 3 months. The growth process continues and thickens with time.
Discussions:
A patient takes up hair transplant only when he or she wants to get rid of baldness and hair thinning problems permanently. Nevertheless, it has been reported that hair thinning is also seen post this cosmetic surgery. It is also called “shock-loss”. This is an important side-effect seen after hair transplant surgery. Another common sight is the appearance of bald patches. An estimated amount of 50 hairs are usually lost each day. The temple and the scalp do often get swollen. Itching and Scratching must be refrained from as that can lead to scab formation.
Conclusion:
According to a recent study, papilla cells and stem cells have been found in the hair follicles. It can be used in correcting baldness with the help of hair multiplication. This method is also called hair cloning. Therefore, it can be concluded that the hair surgical technique has a long way to go. Those who want to opt for this surgery can browse through the internet to gain an in-depth knowledge about hair transplantation. Results have proved that pain is negligible and the recovery time also doesn’t protract. You do not need to be hospitalized nor is any bed rest required. Hair Transplant indeed is a viable choice and is rewarding.
Radiation therapy patient treatment planning & post treatment care new/ Labia...Indian dental academy
The document discusses dental care considerations for patients undergoing radiation therapy for head and neck cancers. It outlines that a dental examination should be performed before treatment to address any dental issues and reduce risks during and after radiation. Extractions should be completed 10-21 days before starting radiation to allow for healing. During radiation, dental care can help prevent oral complications like mucositis and xerostomia. Long term effects on the oral cavity are also discussed. The document emphasizes the importance of dental treatment planning and care coordination between dentists and oncologists for radiation therapy patients.
icometrix offers imaging biomarkers for anatomical MRI or CT images as well as for functional, diffusion and perfusion MR images.
Medical imaging serves as an endpoint in an increasing number of clinical trials for neurological disorders to evaluate the effectiveness of novel therapeutic options and to better understand the pathophysiology. It is critical to obtain objective imaging measurements.Therefore, the use of
high-quality MRI data and quantitative MRI biomarkers is also recommended in the latest guidelines of the European Medicine Agency on clinical investigation of medicinal products for treatment of dementia, multiple sclerosis and other neurological disorders.
Digital Health: Company presentation by Eyal Gura, Co-Founder & CEO of Zebra Medical Vision at the NOAH Conference London 2019, 30-31 October, Old Billingsgate.
Trace evidence such as hair and fibers found at a crime scene can provide important clues about what happened. Hair analysis can determine characteristics like the race of the source and whether drugs were ingested. Microscopic analysis of hair cuticle scale patterns, cortex pigment distribution, and medulla shape and index can indicate if a hair sample matches a suspect or victim. Fiber evidence can also connect a suspect to a crime scene based on the type of polymer and weave of the fiber. Together, hair and fiber evidence through microscopic analysis can help place a suspect at the scene of a crime.
Radiation therapy patient treatment planning & post treatment care newIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
MedicalResearch.com: Medical Research Exclusive Interviews December 14 2014Marie Benz MD FAAD
MedicalResearch.com features exclusive interviews with medical researchers from major and specialty medical research and health care journals and meetings.
Three key points from the document are:
1. Chemotherapy-induced hair loss occurs in approximately 65% of patients undergoing chemotherapy. Hair loss is one of the most traumatic aspects of chemotherapy for many patients.
2. Scalp cooling has been shown to be the most effective method for reducing chemotherapy-induced alopecia according to several clinical studies. One hospital in Northern California currently offers cold caps.
3. The document reviews 5 studies on scalp cooling that range from randomized controlled trials to qualitative studies. The studies show that scalp cooling significantly reduces the risk of chemotherapy-induced alopecia for most chemotherapy regimens.
This document discusses the role of low level laser therapy (LLLT) in the medical management of androgenetic alopecia. It provides an overview of androgenetic alopecia and the mechanisms by which LLLT may stimulate hair follicles. It then describes the author's LLLT dosing protocol and experience treating patients, showing before and after photos demonstrating hair growth with LLLT. The document concludes by referencing supporting literature on LLLT for hair loss.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Post-Menstrual Smell- When to Suspect Vaginitis.pptx
•MEETING UM60 - 2016
1. FEMALE HAIR LOSSFEMALE HAIR LOSS
The diagnosis & managementThe diagnosis & management
is easier than you think!is easier than you think!
Bernard Cohen, MDBernard Cohen, MD
VOLUNTARY CLINICAL PROFESSORVOLUNTARY CLINICAL PROFESSOR
UNIVERSITY OF MIAMI SCHOOL OF MEDICINEUNIVERSITY OF MIAMI SCHOOL OF MEDICINE
JANUARY 16, 2016JANUARY 16, 2016
MIAMI BEACH, FLMIAMI BEACH, FL
2. DISCLOSUREDISCLOSURE
Dr. Cohen owns the patents, and receives royaltiesDr. Cohen owns the patents, and receives royalties
on hair mass measuring technologies.on hair mass measuring technologies.
3. In a general dermatology practice...In a general dermatology practice...
90% of women presenting with hair loss have:90% of women presenting with hair loss have:
ThinningThinning REDUCTION IN DIAMETERREDUCTION IN DIAMETER
SheddingShedding REDUCTION IN DENSITYREDUCTION IN DENSITY
BreakageBreakage RARELY A COMPLAINTRARELY A COMPLAINT
AND A SCALP BIOPSY IS NOT REQUIREDAND A SCALP BIOPSY IS NOT REQUIRED
TO MAKE THE DIAGNOSISTO MAKE THE DIAGNOSIS
4. FOUR STEPSFOUR STEPS
1. Make the diagnosis1. Make the diagnosis
Combinations frequently existCombinations frequently exist
2. Establish baselines2. Establish baselines
““How much hair” is present before treatmentHow much hair” is present before treatment
3. Choose a treatment3. Choose a treatment
4. Manage with measureable feedback4. Manage with measureable feedback
““MEASUREABLEMEASUREABLE”” FEEDBACK =FEEDBACK = ““EVIDENCE-BASEDEVIDENCE-BASED””
10. PHYSICAL EXAMPHYSICAL EXAM RULE OUT THE “UNCOMMON 10%”RULE OUT THE “UNCOMMON 10%”
Frontal fibrosing alopeciaFrontal fibrosing alopecia
Diffuse and patchy AADiffuse and patchy AA
SLE, infection, inflammationSLE, infection, inflammation
Scarring alopecias, etc.Scarring alopecias, etc.
BIOPSY MIGHT BE REQUIREDBIOPSY MIGHT BE REQUIRED
11. PHYSICAL EXAM– ThinningPHYSICAL EXAM– Thinning
PART - Xmas treePART - Xmas tree
DISTRIBUTION - Horseshoe retentionDISTRIBUTION - Horseshoe retention
12. PHYSICAL EXAM– SheddingPHYSICAL EXAM– Shedding
PART -- Widened but no Xmas treePART -- Widened but no Xmas tree
DISTRIBUTION -- Generalized, no horseshoeDISTRIBUTION -- Generalized, no horseshoe
PULL TEST -- PositivePULL TEST -- Positive
13. PHYSICAL EXAM– BreakagePHYSICAL EXAM– Breakage
SLIDE DISTALLY ALONG PONYTAIL GRASP 6-10 HAIRSSLIDE DISTALLY ALONG PONYTAIL GRASP 6-10 HAIRS
Look for drop outs Try to break the bundleLook for drop outs Try to break the bundle
19. THINNING
WIDE RANGE OF DIAMETERSWIDE RANGE OF DIAMETERS
FOLLICULAR UNITS ARE PREDOMINATELY SINGLE HAIRFOLLICULAR UNITS ARE PREDOMINATELY SINGLE HAIR
21. Picture of ourPicture of our
Lab slip
STANDARDIZED “HAIR-RELATED” REQUISITION FORMSTANDARDIZED “HAIR-RELATED” REQUISITION FORM
Thinning will be diagnosed by micro-imaging.Thinning will be diagnosed by micro-imaging.
Blood tests are needed to screen for shedding, which frequently co-exists.Blood tests are needed to screen for shedding, which frequently co-exists.
27. ABSTRACT
Background: Hair loss affects millions worldwide. At
present, most dermatologists use simple, non-
quantitative methods to monitor hair loss progression
and response to treatment, with an emphasis on density
alone. However, the diameter of the hair fibers also
contributes greatly to the appearance of hair.
Objective: Evaluate the accuracy and sensitivity of a
cross-section trichometer (the HairCheck® device), a
simple, hand-held device that measures hair mass
influenced by both density and diameter.
Materials and Methods: Using surgical silk and cut
human hair, we analyzed the correlations between the
HairCheck® readings, the number and diameter of
strands, and the bundle dry weight.
Results: Direct correlations were observed between a
bundle’s cross-sectional area, displayed as the Hair
Mass Index (HMI), the number of strands, fiber diameter,
and bundle dry weight.
Conclusion: Cross-Section Trichometry (CST), the
HairCheck® System and its methodology to determine
the HMI, may provide a quick and accurate tool to
assess progressive alopecia and treatment response in
the clinic.
CONCLUSIONS
• Direct correlations were observed between the
bundle’s cross-sectional area, displayed as the Hair
Mass Index (HMI), the number of strands, the silk/hair
diameter, and the bundle dry weight. Therefore, HMI is a
meaningful measure of the hair mass.
• We have given the name Cross-Section Trichometry
(CST) to the trichometer system and its methodology.
CST is a simple modality that can quickly and accurately
measure the cross-sectional area of a bundle of hair, and
converts it to HMI for display.
REFERENCES
ACKNOWLEDGMENTS
• Arnold J. Hair mass index. 4th Annual Congress European
Society of Hair Restoration Surgery Barcelona 2001.
• Cohen B. The cross-section trichometer: a new device for
measuring hair quantity, hair loss, and hair growth. Dermatol
Surg 2008;34:900-10; discussion 10-1.
• Hendriks MA, Geerts PA, Dercksen MW, van den Hurk CJ ,
Breed WP. Evaluation of Cohen's Cross-Section Trichometer
for Measuring Hair Quantity. Dermatol Surg 2012. [Epub]
Cross-Section Trichometry, A Clinical Tool
for Assessing the Progression and Treatment Response of Alopecia
Joaquin J. Jimenez, Tongyu Cao Wikramanayake, Lucia M. Mauro, Irene A. Tabas,
Anne L. Chen, Isabel C. Llanes, Lawrence A. Schachner
Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL
EXPERIMENTAL PROCEDURES
TCW is the recipient
of a Career
Development Award
from NIH/NIAMS
(AR050487).
RESULTS
RESULTS
INTRODUCTION
Figure 3. Cross-Section Trichometry (CST) of surgical
silk. (a) Correlation between the number of 5-0 strands
and Hair Mass Index (HMI). (b) CST of mixed silk
strands of different types/diameters. (c) Correlation
between HMI, the number of strands, and bundle weight.
c
87
79
72
64
57
50
49
35
30
25
21
16
11
0
10
20
30
40
50
60
70
80
90
100
HMI
ba
2
11
21
29
38
51
55
63
0
10
20
30
40
50
60
70
0 20 40 60 80 100120140 160180
HMI
Number of Silk Strands
r=0.9969
31 34
40 43
50
55 58
65.3
80.282.8
88.6
97.499.4
105.3
0
20
40
60
80
100
120
80 90 100 110 120 130 140 150 160
HMI
Number of Silk Strands
Weight(0.01g)
r=0.9953
r=0.9656
Type
Number of Surgical Silk Strands
3-0 80 60 40 20
4-0 20 40 60 80 60 40 20
5-0 20 40 60 80 60 40 20
6-0 20 40 60 80
Figure 4. Cross-
Section Trichometry
of bundles of cut
human hair using the
HairCheck® device.
Shown is correlation
between the HMI, the
number of hair
strands, and bundle
weight.
23 24 25 27 28 29 30 31 32
48.2
50.9 52.3
55.2 55.8 57.4
59.1
62.0
64.7
0
10
20
30
40
50
60
70
310 320 330 340 350 360 370 380 390 400 410
HMI
Number of Hair Strands
Weight(0.01g)
r=0.9959
r=0.9874
Applications of Cross Section Trichometry:
• Early detection of non-visible hair loss.
• Progression of hair loss.
• Evaluation of response to hair loss treatments (drugs,
devices and over-the-counter products).
• For hair transplantation, CST in the donor area during
initial consultation will help develop realistic
expectations.
• Assess hair breakage.
a b
c
d
e
mm
0 1 2 3 4 5
Figure 1. For assays of hair
density, any hair with a diameter
of greater than 30µm is counted
as one hair without consideration
of the variation in hair diameter.
But for conditions such as
androgenetic alopecia, the hair
diameter varies greatly (left).
• Currently, most dermatologists use simple, non-
quantitative methods to evaluate alopecia, with an
emphasis on hair density alone.
• Small decreases in hair density are not easily detected
by the naked eye, e.g., in global photographs.
• In addition to density, the diameter of hair fibers also
contributes greatly to the appearance of hair mass.
Figure 2. The HairCheck® System consists of a locating
strip (a,b) attached to a pair of eyeglasses (a) and the
measuring device (c,d). A four-legged template is
placed on a numbered tab of the locating strip (b) to
mark the sample site, and the tab number is recorded to
allow return to the same site for future measurements.
The measuring device is hand-held and transmits a pre-
determined load to a bundle of hair (at least 2.5 cm [1
inch] in length) captured by a J-slot (c, d, e). The hair
can be of any type, from super fine to very coarse.
Obtaining the Hair Mass Index (HMI): Bundles of
surgical silk or cut human hair were placed in the J-slot
of the measuring device (c). When the lever arm is
squeezed (d), the cross sectional area of the bundle is
instantaneously displayed as the HMI on the device’s
LED screen and expressed as: mm2 of hair per cm2 of
scalp x 100, rounded up to the closest integer.
All details & published data @All details & published data @ www.howtomeasurehair.comwww.howtomeasurehair.com
SIMULTANEOUSLY MEASURE DENSITY & DIAMETERSIMULTANEOUSLY MEASURE DENSITY & DIAMETER
28. •
b
EXPERIMENTAL PROCEDURES
a b
c
d
e
Figure 2. The HairCheck® System consists of a locating
strip (a,b) attached to a pair of eyeglasses (a) and the
measuring device (c,d). A four-legged template is
HAIR MASS MEASUREMENT
29.
30. THETHE DEVICEDEVICE MEASURES THE CROSS SECTIONALMEASURES THE CROSS SECTIONAL
AREA ON THE HAIR.AREA ON THE HAIR.
THETHE TEMPLATETEMPLATE MEASURES THE CROSS SECTIONALMEASURES THE CROSS SECTIONAL
AREA ON THE SCALPAREA ON THE SCALP
A single numeric value = mmA single numeric value = mm22
of hair per cmof hair per cm22
of scalpof scalp
31. So... In the treatment period... If
THE DIAMETERS GET BIGGER OR SMALLER
OR
THE DENSITY GETS HIGHER OR LOWER
The value displayed on the LED screen
will reflect those changes.
SENSITIVITY
Device can detect a change of 3 hairs in a bundle of 600 hairs.
33. TREATMENTTREATMENT
SHEDDINGSHEDDING
Review blood test resultsReview blood test results
Correct deficiencies and abnormalitiesCorrect deficiencies and abnormalities
Refer patient to appropriate specialistRefer patient to appropriate specialist
If physiologic, re-assure patient ofIf physiologic, re-assure patient of
expected return to normalexpected return to normal
36. MANAGEMENTMANAGEMENT
Same for shedding & thinningSame for shedding & thinning
Use Hair Mass MeasurementUse Hair Mass Measurement
(CROSS SECTION TRICHOMETRY)(CROSS SECTION TRICHOMETRY)
to guide your management decisions.to guide your management decisions.
Casual photography is of value, but is not evidence-based.Casual photography is of value, but is not evidence-based.
It is too imprecise and does not generate measureable data.It is too imprecise and does not generate measureable data.
If less than 50% of the hair has been lost -If less than 50% of the hair has been lost -
the underlying skin will not be visible to the eye (or camera).the underlying skin will not be visible to the eye (or camera).
38. DOCTOR, I THINK I’M LOSING MY HAIRDOCTOR, I THINK I’M LOSING MY HAIR
92-72/92 = 22%92-72/92 = 22%
SHE HAS A 22% LOSS (THINNING) WHICH CANNOTSHE HAS A 22% LOSS (THINNING) WHICH CANNOT
BE SEEN VISUALLY, OR ON CAMERABE SEEN VISUALLY, OR ON CAMERA
7272
9292
39. BASELINEBASELINE
She chooses toShe chooses to
postpone treatmentpostpone treatment
49497272 6767
12 MONTHS LATER12 MONTHS LATER
She is 7% worseShe is 7% worse
40. BASELINEBASELINE
She chooses to startShe chooses to start
laser therapylaser therapy
49496767 7575
12 MONTHS LATER12 MONTHS LATER
She’s only 10% improvedShe’s only 10% improved
41. BASELINEBASELINE
She’s dissatisfied and agreesShe’s dissatisfied and agrees
to add MNX to her laser therapyto add MNX to her laser therapy
49497575 8181
12 MONTHS LATER12 MONTHS LATER
She has a 7% improvementShe has a 7% improvement
with combination therapywith combination therapy
42. BASELINEBASELINE
But the MNX is too difficult to applyBut the MNX is too difficult to apply
bid, she wants to apply qd.bid, she wants to apply qd.
49498383 8282
6 MONTHS LATER6 MONTHS LATER
Surprisingly she isSurprisingly she is
no worseno worse
43. 5 MONTHS AFTER5 MONTHS AFTER
CHILDBIRTHCHILDBIRTH
Patient is actively shedding and frantic.Patient is actively shedding and frantic.
She is re-assured and not treated.She is re-assured and not treated.
49495555 7777
12 MONTHS AFTER12 MONTHS AFTER
CHILDBIRTHCHILDBIRTH
She is 30% improvedShe is 30% improved
And almost back to normalAnd almost back to normal
44. BASELINEBASELINE
A low ferritin and Vitamin DA low ferritin and Vitamin D
are picked up on blood screening.are picked up on blood screening.
Treatment is commenced.Treatment is commenced.
49497979 8686
12 MONTHS LATER12 MONTHS LATER
She is 9% improved afterShe is 9% improved after
one year.one year.
45. IS IT DIFFUSEIS IT DIFFUSE OROR PATTERN HAIR LOSS?PATTERN HAIR LOSS?
(occiput & mid scalp essentially equal)(occiput & mid scalp essentially equal)
CONCLUSION = Hair Loss is DIFFUSE not PATTERNCONCLUSION = Hair Loss is DIFFUSE not PATTERN
6262
6464
46. BASELINEBASELINE
Patient reluctantly startsPatient reluctantly starts
minoxidil for thinning.minoxidil for thinning.
49496565 7979
8 MONTHS LATER8 MONTHS LATER
““Doc, I don’t think theDoc, I don’t think the
minoxidil is working.”minoxidil is working.”
48. IS IT DIFFUSEIS IT DIFFUSE OROR PATTERN HAIRPATTERN HAIR
LOSS?LOSS?
(occiput & mid scalp essentially equal)(occiput & mid scalp essentially equal)
6868 6767
Editor's Notes
In a general dermatology practice – 90% of women with hair loss have one of three diagnoses
Or a combination of 2 or 3
A scalp biopsy is not required
I will attempt to show you how to makethe diagnosis – remembering that (combinations do exist)
Then establish your treatment starting point or baselines
And then–how to manage the treatment– using modalities that give you evidence-based feedback
So… make thte diagnosis – establish the baselines – then treat and manage
You’ll want to ask these questions in your medical history. They all point to thinning
Hit these items in your medical history. They point to shedding
Hit these items in your medical history. They point to thinning
So… make thte diagnosis – establish the baselines – then treat and manage
On physical exam, try to identify the less common 10%
In these cases a biopsy might be required
Part the hair down the midline. A Xmas tree distribution is highly suggestive sign of thinning
Retention of hair in the horseshoe fringe is a sign of thinning as well
When the hair is parted – look for general widening with no Xmas tree – that suggests shedding
The distribution of loss is diffuse . Then Grasp 20 or 30 hairs and give them a tug. If more than 3 come out it’s a positive pull test.
Because theres a high proportion of telogen hairs in states of effluvium
To check for breakage put together a pony tail and examine with a contrasting background.
The short broken hairs fall out of the bundle.
The take 5 or six hair, wrap around your fingers and try to break them. Brittle hair with break easily.
So… make thte diagnosis – establish the baselines – then treat and manage
It’s a dermatoscope
The phone slips into a shell that contains a lens and light source.
The device comes with a good archival software for keeping track of the photos
The image on the left is what you see.
On the right is the same image zoomed in for close examination
In cases of shedding expect to see hairs of essentially all the same diameter
In cases of thinning, the hairs become progressively miniaturized
So on the left -- a micro-image of cut hair. Note the wide variation of diameters and the single hair follicular units.
On the right is what you see using the PhotoFinder– Take a look at how easily the variation can be seem – there is no need to cut hair
So… make thte diagnosis – establish the baselines – then treat and manage
We use a form that contains the hair-related lab test and diagnoses.
Tip –Don’t use a hair diagnosis - use Unspecified endocrine disorder 259.9 and the tests are rarely denied
the the insurance company.
90% of women with thinning but a small percentage have an adrenal hormone imbalance identified with DHEAS and testosterone
So… make thte diagnosis – establish the baselines – then treat and manage
So… make thte diagnosis – establish the baselines – then treat and manage
This technology – called cross section trichometry – has been published by me as well as Drs. Jimenez and Cao.
It is in multiple published articles and textbook chapters Used by Loreal, Proctor and Gamble, and Unilever
IT CONSISTS OF -- READ THE SLIDE
So… make thte diagnosis – establish the baselines – then treat and manage
So… make thte diagnosis – establish the baselines – then treat and manage
I would also add breakage
I would also add breakage
A female with hair loss can be measured in two areas
If the occiput and mid scalp are about equal, the hair loss is diffuse
If the mid scalp is less than the occiput then she would have androgenetic alopecia
We can track the progress of propecia, minoxidil, laser, biotin, transplants
Or evaluate low level laser therapy
This patient is 21% improved after one year
We can track the progress of propecia, minoxidil, laser, biotin, transplants
Or evaluate low level laser therapy
This patient is 21% improved after one year
We can track the progress of propecia, minoxidil, laser, biotin, transplants
Or evaluate low level laser therapy
This patient is 21% improved after one year
We can track the progress of propecia, minoxidil, laser, biotin, transplants
Or evaluate low level laser therapy
This patient is 21% improved after one year
We can track the progress of propecia, minoxidil, laser, biotin, transplants
Or evaluate low level laser therapy
This patient is 21% improved after one year
We can track the progress of propecia, minoxidil, laser, biotin, transplants
Or evaluate low level laser therapy
This patient is 21% improved after one year
A female with hair loss can be measured in two areas
If the occiput and mid scalp are about equal, the hair loss is diffuse
If the mid scalp is less than the occiput then she would have androgenetic alopecia
We can track the progress of propecia, minoxidil, laser, biotin, transplants
Or evaluate low level laser therapy
This patient is 21% improved after one year
As heres an example I gave earlier
3 measurement
Pt has a 50% loss on the vertex and a 12% loss in the midscalp