Medicines used for COVID-19 is discussed in these slide, be safe be aware.

1. MEDICINE AND DIAGNOSIS FOR NOVEL COVID-19
AJAY SAMUEL.S
III UG BIOTECHNOLOGY
RATHNAVEL SUBRAMANIYAM COLLEGE OF ARTS AND
SCIENCE , COIMBATORE

2. MEDICINES
• Corona virus being a pandemic threat to human on this
current scenario it is essential to prevent and to invent new
medicines for the disease .
• According to nature research journal CHLOROQUINE -an
approved malaria drug — is known in nanomedicine research
for the investigation of nanoparticle uptake in cells, and may
have potential for the treatment of COVID-19.
• HON'BLE US president DONALD TRUMP stated that “Now, a
drug called chloroquine—and some people would add to it
'hydroxy-.' Hydroxychloroquine. So chloroquine or
hydroxychloroquine. Now, this is a common malaria drug,".

3. CONTINUED...
• So researches shows some opositive results on internet,
were malarial drug slightly proves is efficasy against
COVID-19.
• Ides of using hydroxychoroquine came from the SARS
2005 where it is administrated for SARScoV-1 wich
showed positive result on redusing the ilness and
nullifiying the viral infection.
• Now sudden onset of combo drug for corona virus shows
negligible positive results.

4. REASON BEHIND.....

5. Biospace journal article

6. what happens?
• Hydroxychloroquine increases the pH inside the late
endosomes, so coronavirus inside the late endosomes
that require low pH to release its genome. High pH makes
it imposible.
• Azithromycin protects the weakend host from bacterial
infection.
• Combo drug also acts as a immunomodulators, so over
activated immune cells cannot affect host cells.

7. • At least three big drug companies, Mylan, Novartis and Teva
Pharmaceutical have agreed to increase production of
hydroxychloroquine, with plans to donate literally tens of
millions of doses of the drug hoping it can be used to treat
COVID-19. On March 17, the University of Minnesota initiated
a clinical trial of hydroxychloroquine for treatment of COVID-
19. French researchers have published an article in the
International Journal of Antimicrobial Agents describing the
potential use of a combination of hydroxychloroquine and the
antibiotic azithromycin, which is better known as Z-Pak. The
U.S. Food and Drug Administration (FDA) is also evaluating
the drugs but have not yet made recommendations.

8. • IHU-Mediterranee Infection in Marseille, France, stated, “A
treatment with the hydroxychloroquine combination (200 mg X
3 per days for 10 days) + Azithromycin (500 mg on the 1st
day then 250 mg per day for 5 more days), as part of the
precautions for use of this association (including an
electrocardiogram on D0 and D2). In cases of severe
pneumonia, a broad-spectrum antibiotic is also used. We
believe that it is not ethical that this association should not be
systematically included in therapeutic trials concerning the
treatment of COVID-19 infection in France.”

9. DIAGNOSIS kit

10. REFERENCES
• BIOSPACE .COM/MARK TERRY
• CONTAGIONLIVE.COM/COVID19 TREATMENT
• COMMONDREAMS.ORG/NIGERIA REPORTS
• NATURE.COM/NATURE NANOTECHNOLOGY.
• GOOGLE