The ability of the fetus to successfully negotiate the pelvis during labor involves changes in the position of its head during its passage in labor. The mechanisms of labor, also known as the cardinal movements, are described in relation to a vertex presentation, as is the case in 95% of all pregnancies.
This topic contains definition, incidence, types, causes, diagnosis, mechanism, management of occipito posterior position and deep transverse arrest and manual rotation of occipito posterior position
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
The ability of the fetus to successfully negotiate the pelvis during labor involves changes in the position of its head during its passage in labor. The mechanisms of labor, also known as the cardinal movements, are described in relation to a vertex presentation, as is the case in 95% of all pregnancies.
This topic contains definition, incidence, types, causes, diagnosis, mechanism, management of occipito posterior position and deep transverse arrest and manual rotation of occipito posterior position
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
1. MECHANISM OF LABOUR
Lateefa Al Dakhyel FRCSC, FACOG
Assistant professor & consultant
Obstetric & gynecology department
Collage of medicine
King Saud University
2. Lie, presentation, attitude, &position
FETAL LIE
The relation of the long axis of the fetus to that of the mother
1-Longitudinal lie -99% of labors at term
2-transverse lie multiparty, placenta previa, hydramnious, &
uterine anomalies
3-oblique lie -maternal & fetal axes cross @ 45 angle
-most unstable & become longitudinal Or
transverse at labor.
3. ATTITUDE or posture.
In later months posture of the fetus folded on itself to
accommodate the shape of the uterus (flexed head,
thighs, knees &feet ,the arms crossed over the chest)
Change from this flexed attitude can cause abnormal
presentations
5. Fetal position
The relation of a chosen point of the fetal presenting part to
the Rt or Lt side of the maternal birth canal
The chosen point
Vertex presentation occiput
Face presentation mentum
Breech presentation Sacrum
Each presentation has two positions Rt or Lt
Each position has 3 varieties : Ant, transverse, post
OA
OP
LOT
ROT
LOA
ROA
LOP
ROP
6.
7. Lie, presentation, attitude, &position
CEPHALIC PRESENTATION
Head is flexed sharply vertex / occiput presentation
Head is extended sharply face presentation
Partially flexed bregma presenting (sinciput presentation)
Partially extended brow presentation
BREECH PRESENTATION
Frank breech
Complete breech
Footling breech (incomplete breech)
.
8.
9. FREQUENCY OF VARIOUS PRESENTATIONS &
POSITIONS AT TERM
Vertex 96%
2/3 Lt
1/3 Rt
Breech 3.5%
Face 0.3%
Shoulder 0.4%
10. MECHANISM OF LABOUR WITH OCCIPUT
PRESENTATIONS
THE CARDINAL MOVEMENTS OF LABOUR
1-ENGAGEMENT
The greatest transverse diameter BPD passes through the
pelvic inlet
It may occur in the last few weeks of pregnancy or only in
labour especially in multipara
The fetus enters the pelvis in transverse or oblique diameter
LOT 40%
ROT 20%
OP 20% ROP >LOP
ROA / LOA 20%
11.
12. THE CARDINAL MOVEMENTS OF LABOUR
2-DESCENT
In nullipara engagement takes place before the onset of
labour & further descent may not occur till the 2nd stage
In multipara descent begins with engagement
It is gradually progressive till the fetus is delivered
It is affected by the uterine contractions & thinning of the
lower segment
13. 3-flexion
The descending head meets resistance of pelvic floor, Cx
& walls of the pelvis flexion
The shorter suboccipito-begmatic is substituted for the
longer occipito-frontal
14. Lever action producing ftexion of the head; conversion
from occipitofrontal to suboccipitobregmatic diameter
typically reduces the anteroposterior diameter from
nearly 12- to 9.5 cm.
15. 4-INTERNAL ROTATION
Turning of the head from the OT position anteriorly
towards the symphysis pubis ie. Occiput moves from
transverse to ant 45º
Less commonly OT posteriorly towards the sacrum
135º
It is not accomplished till the head has reached the spines
The levator ani muscles form a V shaped sling that tend to
rotate the vertex anteriorly
16. 5-EXTENSION
When the flexed head reaches the vulva it undergoes
extension the base of the occiput will be in direct contact
with the inferior margin of the symphysis pubis
Crowning the largest diameter of the fetal head is
encircled by the vulvar ring
The head is born by further extension as the occiput,
bregma (ant.fontanelle), forehead, nose, mouth & chin
pass successively over the perineum
17. 6-EXTERNAL ROTATION
RESTITUTION
After delivery of the head it returns to the position it
occupied at engagement , the natural position relative to
the shoulders (oblique position)Restitution
Then the fetal body will rotate to bring one shoulder
anterior behind the symphysis pubis ( biacromial diameter
into the APD of the pelvic outlet)
Restitution is followed by complete external rotation to
transverse position (occiput lies to next to Lt maternal
thigh)
The ant shoulder slips under the pubis
By lateral flexion of the fetal body the post shoulder will be
delivered & the rest of the body will follow
18. 3
0
2
2.Engagement;descent, flexion 6. Restitution (external rotation)
3. Further descent, internal rotation
4. Complete rotation, beginning
extension
Cardinal movements in the
mechanism of labor and
delivery, left occiput
anterior position.
19. OCCIPUT POSTERIOR POSITION
Mechanism of labour is identical to OT & anterior varieties
Usually more longer.
The occiput rotate to the symphysis pubis through 135º
instead of 90º or 45º
If rotation does not occur direct occiput post (5-10%)or
Partial rotation transverse arrest
20. Mechanism of labor for right occiput
posterior position, anterior rotation.
,
.
,
0
21. Q.1-Commonest presentation during labor is
1-left occiput anterior position (LOA)
2-right occiput anterior (ROA)
3-occiput transverse (OT)
4-left occiput posterior (LOP)
Q.2- about breach presentation which is correct
1-beech presentation is the more common in primeparous
2-incomlete breach can’t be delivered vaginally
3-breach presentation can’t be diagnosed clinically
4-all breach presentation should be delivered by C/S
Q.3-during labor
1-engagment occur when BPD reach the pelvic outlet
2-engagment always occur before onset of labor in prime.
3-if internal rotation to SP is 135 degree it will be OP
4-if the head is flexed it will be face presentation