This document contains information about two case studies treated with homeopathy by Dr. Subrata K. Banerjea. The first case describes a patient suffering from severe dehydration who was not responding to allopathic treatment. Upon observing the patient touching parts of their body as if feeling sparks of fire, Dr. Banerjea prescribed Secale Cor which led to dramatic improvement within 12 hours. The second case describes a young woman suffering from fibromyalgia due to long hours standing at her job. Previous homeopathic remedies had not helped, but Dr. Banerjea prescribed Squilla based on its indication for sore and tender feet in those who stand for long periods, leading to improvement within three months.
Content:
Introduction
History
Chemistry of artemisinin
Structural activity relationship of artemisinin
Mechanism of action
Drug interactions
Malaria is a very common disease. This probably originated in Africa around 30 million years ago.
In 1600s first treatment to malaria was recorded in Peru where native tribes used bitter bark of cinchona, to reduce the fever and pain.
In 1897 Sir Ronald Ross described female anopheles mosquito as the vector of the disease.
In 1950s the disease rebounded largely due to emergence of parasites resistant to drugs like chloroquine.
In 1967 a plant screening research program code named “Project 523” was set up in China by the People’s liberation army ordered by Mao Zedong at the request of North Vietnamese.
Under able leadership of Dr. Y. Tu more than 2000 herbs preparations were investigated . Out of which 640 herbs were hits.
The turning point came when Sweet wormwood extract showed a promising degree of inhibition in mouse model.
Although the progress was not smooth as the observation was not reproducible in subsequent experiments.
During cultural revolution no clinical trials were performed so Dr. Tu bravely volunteered to the first trials.
In Hainan first official trials happened on malaria patients. The patients showed much better result than chloroquine (Test samples).
Encouraged by this outcome, she moved on to investigate and isolated the pure compound of Artemisia.
In 1972 a colorless crystalline substance with a mol wgt. of 282 Da, having molecular formula of C15H22O5 was isolated. The molecule was named as Qinghau su (Artemisinin) from the leaves of Sweet wormwood scientifically known as Artemisia annua, family Compositae.
Dr. Y. Tu was awarded with Lasker DeBakey clinical medical research award in 2011 and finally the Nobel Prize in physiology and medicine of artemisinin in 2015.
SAR OF ARTEMISININ
Tetracyclic structure with a trioxane ring and a lactone ring.
Trioxane ring contains a peroxide bridge, the active moiety of the molecule.
MOL. FORMULA: C15H22O5; MOL .MASS: 282.332
Presence of a ‘Trioxane’ moiety which consists of the endoperoxide & doxepin oxygens that is evidently displayed by a simplified version of 3- aryltrioxanes.
Modification of 10th position ‘C’ gives a powerful derivative compared to the original compound.
Reduction of artemisinin to dihydroartemisinin gives rises to a chiral centre that may ultimately lead to the formation of prodrugs.
Artemisinin is a poorly soluble in oils and water so it is administered through oral, IM or rectal route.
Semi synthetic like artesunate, artemether arteether and hemisuccinate ester were produced because of poor bioavailability and limit of its effectiveness.
To stop the malarial activity, the target was a retroviral aspartyl protease which can be found in the plasmodium faliciparum parasite.
The metabolite dihydroartemisinin cleaves the endoperoxide ring inside the erythrocyte.
Epidemiology of cholera, its history and clinical features are described. The prevention of cholera has also been discussed. Global roadmap for ending cholera by 2030 is also briefly touched upon. This would be useful for medical students.
Dr. Treacy is a Fellow of The Royal Society of Medicine and a Fellow of The Royal Society of Arts.
He is a member of The Irish College of Cosmetic Doctors, The British Association of Cosmetic
Doctors, The British Medical Laser Association, The American Society for Aesthetic Medicine, The
American Society for Lasers in Medicine and Surgery, The European Society of Laser Dermatology,
The European Society for Dermatological Surgery (ESDS), The International Society for Dermatologic
Surgery, The International Academy of Cosmetic Dermatology
Contact:
Ailesbury Clinics Ltd Suite 6 Merrion Road Ailesbury Road Dublin 4 Ireland
Phone +35312692255/2133 Fax +35312692250
www.ailesburyclinic.ie
Livingstone Chishimba Q & A session with National Aspergillosis Centre patien...Graham Atherton
Dr Livingstone Chishimba is a specialist aspergillosis doctor working at the National Aspergillosis Centre, Manchester, UK.
This is the second session he has run discussing & answering questions from our patients and those who are members of our support groups online
http://uk.groups.yahoo.com/group/AspergillusSupport/
Content:
Introduction
History
Chemistry of artemisinin
Structural activity relationship of artemisinin
Mechanism of action
Drug interactions
Malaria is a very common disease. This probably originated in Africa around 30 million years ago.
In 1600s first treatment to malaria was recorded in Peru where native tribes used bitter bark of cinchona, to reduce the fever and pain.
In 1897 Sir Ronald Ross described female anopheles mosquito as the vector of the disease.
In 1950s the disease rebounded largely due to emergence of parasites resistant to drugs like chloroquine.
In 1967 a plant screening research program code named “Project 523” was set up in China by the People’s liberation army ordered by Mao Zedong at the request of North Vietnamese.
Under able leadership of Dr. Y. Tu more than 2000 herbs preparations were investigated . Out of which 640 herbs were hits.
The turning point came when Sweet wormwood extract showed a promising degree of inhibition in mouse model.
Although the progress was not smooth as the observation was not reproducible in subsequent experiments.
During cultural revolution no clinical trials were performed so Dr. Tu bravely volunteered to the first trials.
In Hainan first official trials happened on malaria patients. The patients showed much better result than chloroquine (Test samples).
Encouraged by this outcome, she moved on to investigate and isolated the pure compound of Artemisia.
In 1972 a colorless crystalline substance with a mol wgt. of 282 Da, having molecular formula of C15H22O5 was isolated. The molecule was named as Qinghau su (Artemisinin) from the leaves of Sweet wormwood scientifically known as Artemisia annua, family Compositae.
Dr. Y. Tu was awarded with Lasker DeBakey clinical medical research award in 2011 and finally the Nobel Prize in physiology and medicine of artemisinin in 2015.
SAR OF ARTEMISININ
Tetracyclic structure with a trioxane ring and a lactone ring.
Trioxane ring contains a peroxide bridge, the active moiety of the molecule.
MOL. FORMULA: C15H22O5; MOL .MASS: 282.332
Presence of a ‘Trioxane’ moiety which consists of the endoperoxide & doxepin oxygens that is evidently displayed by a simplified version of 3- aryltrioxanes.
Modification of 10th position ‘C’ gives a powerful derivative compared to the original compound.
Reduction of artemisinin to dihydroartemisinin gives rises to a chiral centre that may ultimately lead to the formation of prodrugs.
Artemisinin is a poorly soluble in oils and water so it is administered through oral, IM or rectal route.
Semi synthetic like artesunate, artemether arteether and hemisuccinate ester were produced because of poor bioavailability and limit of its effectiveness.
To stop the malarial activity, the target was a retroviral aspartyl protease which can be found in the plasmodium faliciparum parasite.
The metabolite dihydroartemisinin cleaves the endoperoxide ring inside the erythrocyte.
Epidemiology of cholera, its history and clinical features are described. The prevention of cholera has also been discussed. Global roadmap for ending cholera by 2030 is also briefly touched upon. This would be useful for medical students.
Dr. Treacy is a Fellow of The Royal Society of Medicine and a Fellow of The Royal Society of Arts.
He is a member of The Irish College of Cosmetic Doctors, The British Association of Cosmetic
Doctors, The British Medical Laser Association, The American Society for Aesthetic Medicine, The
American Society for Lasers in Medicine and Surgery, The European Society of Laser Dermatology,
The European Society for Dermatological Surgery (ESDS), The International Society for Dermatologic
Surgery, The International Academy of Cosmetic Dermatology
Contact:
Ailesbury Clinics Ltd Suite 6 Merrion Road Ailesbury Road Dublin 4 Ireland
Phone +35312692255/2133 Fax +35312692250
www.ailesburyclinic.ie
Livingstone Chishimba Q & A session with National Aspergillosis Centre patien...Graham Atherton
Dr Livingstone Chishimba is a specialist aspergillosis doctor working at the National Aspergillosis Centre, Manchester, UK.
This is the second session he has run discussing & answering questions from our patients and those who are members of our support groups online
http://uk.groups.yahoo.com/group/AspergillusSupport/
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
