1. MATTHEW KOHLS mkohls68@gmail.com
619-733-4170 | Matt LinkedIn
SCIENTIST / PRODUCT MANAGER – R&D Biotechnology
PROFESSIONAL EXPERIENCE
ADVANCED TARGETING SYSTEMS, San Diego, CA 1998-Present
Dedicated to creating targeted conjugates for specific cell elimination and translating into clinical therapies for chronic pain
relief.
Research Scientist I & II, 2008 – Present
 Principle product development architect in a Senior Scientist role. Fluent in recombinant
design and production, from gene construction and cloning to biologics scale-up and final
purification.
o Engineered fusion proteins, recombinant antibodies, and recombinant toxins
using a variety of organism strains.
o New Product Planning - Lobbied internal executive leadership for budgetary
allotments and project prioritization based on forward-looking corporate vision
and catalog needs.
o Product Manager for catalog portfolio subset including customer and technical
support, public communications via quarterly newsletter contributions, and
tradeshow representation.
o Generated and patented (pending) a recombinant lectin, filling a major gap in
sourcing pipeline. Spearheaded project from cloning & isolation to publishing &
presenting findings at major scientific conferences.
o Authored >10 patent applications including consolidation of in-house data and
publication research.
o Constructed specific and detailed justifications to FDA as part of new drug
applications for human/animal therapies resulting in successful IND and Phase I
human trial.
Asst. Research Scientist, 2002 – 2008
 De facto manager of entire research lab serving as primary researcher, resident
molecular biology expert, cultivator of protein purification techniques, corporate safety
officer, and official trainer of all new laboratory personnel.
o Designed and executed on development of >10 new products to the catalog
resulting in a 3.5-fold increase in company revenue.
o Internal champion from conception to clinical trial for a patented drug product
candidate currently in Phase I trials.
o Created and curated company SOP library in response to need for GLP
standards and in anticipation of future cGMP therapeutic requirements.
o Implemented and honed purification strategies and assay development for all in-
house catalog products – including in vitro & cell-based assays, and liquid
chromatography expertise.
o Contributed critical scientific justification for multiple funded SBIR grants and
grant progress reports.
Sr. Research Associate, 1998 – 2002
 Chief monoclonal antibody developer from serum screening to hybridoma generation.
 Designed Lab space layout and equipment outfitting for two labs from the ground up.
 Expert in western blotting, PCR, ELISA, HPLC, ICC, and Flow Cytometry

2. Matthew Kohls
839 Agate St., San Diego, CA 92109  619 733 4170  mkohls68@gmail.com
CHIRON CENTER FOR GENE THERAPY, San Diego, CA 1997-1998
QC Analyst III,
 Performed QC assays on products intended for use in human gene therapy clinical trials.
 Designed studies on the antigenicity of product formulations.
 Authored and validated new quality control assays.
THE SCRIPPS RESEARCH INSTITUTE, San Diego, CA 1995-1997
Research Associate II,
 Maintained SCID and SCID/NOD mice colonies in a BSL III facility for in vivo HIV
experiments.
 Investigated the use of vaccinia virus for in vitro antigen expression.
THE WHITTIER INSTITUTE, San Diego, CA 1992-1995
Research Associate II,
 While managing laboratory of 8 researchers, cloned FGF-2 and created FGF-2 mutants
as well as a quantitative ELISA for measurement in various tissues..
SELECTED PUBLICATIONS
Gerashchenko D, Kohls MD, Greco M, Waleh NS, Salin-Pascual R, Kilduff TS, Lappi DA,
Shiromani PJ; Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like
sleep behavior in the rat. J Neuroscience. 2001 Sep 15;21(18):7273-83.
Kohls MD, Lappi DA; Mab-ZAP: a tool for evaluating antibody efficacy for use in an immunotoxin.
Biotechniques. 2000 Jan;28(1):162-5.
Geller J, Sionit LR, Baird A, Kohls M, Connors KM, Hoffman RM; In vivo and in vitro effects of
androgen on fibroblast growth factor-2 concentrations in the human prostate. Prostate. 1994
Oct;25(4):206-9.
EDUCATION
BS, Biochemistry and Cell Biology, UNIVERSITY OF CALIFORNIA, San Diego, Graduated
1992
OTHER ACTIVITIES
I have been a gymnastics coach for over 30 years, teaching all ages, recreational and
competitive. Currently I am coaching for the Campus Recreation department at UCSD. I enjoy
photography, travel, and volleyball.