This document provides a 10-step guide for upgrading a Typo3 website from version 3.8.0 to 4.2.0 while also upgrading the PHP version from 4 to 5. The steps include backing up the site, downloading the new Typo3 files, replacing old files with new ones locally and then on the server, switching the server to parse files with PHP 5, copying the database, running the Typo3 install tool, clearing caches, checking for errors and adjustments needed, and additional tasks like changing file paths and character encodings. Proper testing and validation of the upgraded site is recommended at each step.