This document discusses a precision medicine approach to treating Post-Treatment Lyme Disease Syndrome (PTLDS). It uses questionnaires, testing, imaging, and longitudinal data collection to better understand each patient's presentation and develop personalized treatment plans. Examining this data has started to show patterns linking more complex clinical profiles to multiple infections beyond Borrelia or elevated antineuronal antibodies. A precision approach using these diagnostics leads to improved strategies for diagnosis, therapy and rehabilitation for PTLDS patients.