Dr. Lucija Tomljenovic is an early career postdoctoral fellow. She was awarded a PhD in 2009 in Biochemistry, from the Comparative Genomics Centre at James Cook University in Townsville, Australia. In 2010, she joined the Neural Dynamics Research Group at the University of British Columbia (Chris Shaw’s lab) and is currently researching the neurotoxic effects of aluminum vaccine adjuvants. Tomljenovic has recently become an Associate Editor of the Journal of Alzheimer’s Disease. She values open-minded discussions on controversial topics and the pursuit of truth in research endeavors, wherever they may lead.
Panel:
Kathleen Hallal, GMO Free News Host
Rachel Linden, GMO Free News Co-Host
Zoey O'Toole, Thinking Moms Revolution
Dr. Lucija Tomljenovic
Jack Olmsted, Producer
Dr. Mercola Interview with Dr. Tomljenovic: How Vaccine Adjuvants Affect Your Brain
http://articles.mercola.com/sites/articles/archive/2015/03/29/vaccine-adjuvants-brain-effects.aspx
HPV Vaccine Safety and Efficacy Issues: Dr. Tomljenovic's in Vancouver, 2015.
https://www.youtube.com/watch?v=9Uu3iWA1UWw
Question List:
Dr. Tomljenovic: Regarding the questions, if there are no comments it means I will answer these questions during the show:
Which vaccines cause the antibodies to attack the brain?
Are some vaccines/adjuvants more prone to do this? Why or why not?
Comment:That is the million dollar question that no one knows the answer to because this issue has not been studied well enough. Even the pharma admits that they do not know exactly how the adjuvants work. I can give some quotes from the pharma experts.
Just wanted to let you know that I cannot answer this question any better than this.
Did you test OTHER body tissues, or just the brain?
Why would the phenomenon of mimicry only work on the brain tissue?
Comment: It does not work only on brain tissue, it can work on any tissue where there is mimicry between the antigen of the virus/bacteria and that of the host
Have you tried immunizing mice at reduced rates (fewer boosters, like they do in Scandanavian countries) and if so, do they have much fewer issues with autoimmunity?
Comment: We have not immunized the mice (we did not inject them with vaccines), we have only given the mice aluminum in the amounts equivalent to that given to children via vaccinations in the US and Scandinavia. At the time we did this study, we did not look for any autoimmune markers, only behavioral outcomes as well as gene expression in the brains of these mice. In both parameters there were abnormal changes (i.e. abnormal behavior and increased expression of certain pro-inflammatory genes in the brain as well as reduced expression of AChE = acetylcholinesterase which has anti-depression/anxiety effect. Low AChE activity is associated with deficits in neurodevelopment)
That’s important because right now, doctors have to rely on a set of 11 criteria, which can overlap with many other diseases, to try to make a diagnosis.
“It is one of the most complex clinical diagnoses,” says Pascual, who is also a practicing pediatric rheumatologist.
“It might lead to better diagnostic tests, but we don’t know that yet,” Pascual says. Other experts say the discoveries will most certainly lead to new drug targets.
Systemic lupus erythematosus (also called SLE or lupus)
is an autoimmune condition. The normal role of your
body’s immune system is to fight off infections and
diseases to keep you healthy. In an autoimmune disease
like lupus, your immune system starts attacking your
own healthy tissues. For some people lupus may just
affect the skin and/or joints. In other people the lungs,
kidneys, blood vessels,
That’s important because right now, doctors have to rely on a set of 11 criteria, which can overlap with many other diseases, to try to make a diagnosis.
“It is one of the most complex clinical diagnoses,” says Pascual, who is also a practicing pediatric rheumatologist.
“It might lead to better diagnostic tests, but we don’t know that yet,” Pascual says. Other experts say the discoveries will most certainly lead to new drug targets.
Systemic lupus erythematosus (also called SLE or lupus)
is an autoimmune condition. The normal role of your
body’s immune system is to fight off infections and
diseases to keep you healthy. In an autoimmune disease
like lupus, your immune system starts attacking your
own healthy tissues. For some people lupus may just
affect the skin and/or joints. In other people the lungs,
kidneys, blood vessels,
Aberrant muscle antigen exposure in mice is sufficient to cause myositis in a...Nicholas Young
My talk on muscle auto-antigens in myositis presented at the American College of Rheumatology 79th Meeting during the “Myositis and Myopathies: Novel Insights into Disease Pathogenesis” concurrent abstract oral presentation session. November 4, 2012 in Washington, D.C.
“A Chimeric Human-Mouse Model of Sjögren's Syndrome” Nicholas Young
My talk from The Federation of Clinical Immunology Societies (FOCIS) annual meeting June 24-28, 2014 in Chicago, IL: “A Chimeric Human-Mouse Model of Sjögren's Syndrome”. Recipient of a travel award given to selected abstracts to attend this conference.
we are teleologically cardioprotected. we are already cardioprotected. nature has given us everything we need to be unbreakable.we just have to push the right buttons.
please, pay heed to the turtles! they know best!
Lifewave recently unveiled its newest technology on aging. This new nanotechnology is a new form of health care delivery system and is available today. This patch is non-transdermal and no medicine ever enters the body. It simply uses bio-electronic patch the size of a quarter placed on the skin.
Pathophysiology of TBI is complex and consists of acute and delayed injury. In the acute phase, brain tissue destroyed upon impact includes neurons, glia, and endothelial cells, the latter of which makes up the blood-brain barrier. In the delayed phase, “toxins” released from damaged cells set off cascades in neighboring cells eventually leading to exacerbation of primary injury. As researches further explore pathophysiology and molecular mechanisms underlying this debilitating condition, numerous potential therapeutic strategies, especially those involving stem cells, are emerging to improve recovery and possibly reverse damage. In addition to elucidating the most recent advances in the understanding of TBI pathophysiology, this review explores two primary pathways currently under investigation and are thought to yield the most viable therapeutic approach for treatment of TBI: manipulation of endogenous neural cell response and administration of exogenous stem cell therapy.
Aberrant muscle antigen exposure in mice is sufficient to cause myositis in a...Nicholas Young
My talk on muscle auto-antigens in myositis presented at the American College of Rheumatology 79th Meeting during the “Myositis and Myopathies: Novel Insights into Disease Pathogenesis” concurrent abstract oral presentation session. November 4, 2012 in Washington, D.C.
“A Chimeric Human-Mouse Model of Sjögren's Syndrome” Nicholas Young
My talk from The Federation of Clinical Immunology Societies (FOCIS) annual meeting June 24-28, 2014 in Chicago, IL: “A Chimeric Human-Mouse Model of Sjögren's Syndrome”. Recipient of a travel award given to selected abstracts to attend this conference.
we are teleologically cardioprotected. we are already cardioprotected. nature has given us everything we need to be unbreakable.we just have to push the right buttons.
please, pay heed to the turtles! they know best!
Lifewave recently unveiled its newest technology on aging. This new nanotechnology is a new form of health care delivery system and is available today. This patch is non-transdermal and no medicine ever enters the body. It simply uses bio-electronic patch the size of a quarter placed on the skin.
Pathophysiology of TBI is complex and consists of acute and delayed injury. In the acute phase, brain tissue destroyed upon impact includes neurons, glia, and endothelial cells, the latter of which makes up the blood-brain barrier. In the delayed phase, “toxins” released from damaged cells set off cascades in neighboring cells eventually leading to exacerbation of primary injury. As researches further explore pathophysiology and molecular mechanisms underlying this debilitating condition, numerous potential therapeutic strategies, especially those involving stem cells, are emerging to improve recovery and possibly reverse damage. In addition to elucidating the most recent advances in the understanding of TBI pathophysiology, this review explores two primary pathways currently under investigation and are thought to yield the most viable therapeutic approach for treatment of TBI: manipulation of endogenous neural cell response and administration of exogenous stem cell therapy.
GMO Crops, Glyphosate and the deterioration of health in the USAJack Olmsted
This presentation was created from the Google Hangout panel on November 14, 2014 available on YouTube; http://youtu.be/RCGs5JHdfSo
Through an online video panel discussion, Dr. Nancy Swanson explains the per review paper she co-wrote published in the November issue of the Organic Systems Journal entitled, "GENETICALLY ENGINEERED CROPS, GLYPHOSATE AND THE DETERIORATION OF HEALTH IN THE UNITED STATES OF AMERICA Nancy L. Swanson 1, Andre Leu 2*, Jon Abrahamson 3 and Bradley Wallet 4"
Read Paper:
http://www.organic-systems.org/journal/92/abstracts/Swanson-et-al.html
Environmental Consequences of Genetically-Modified Foods, Biopharming and rBGHJack Olmsted
Martin Donohoe, MD, FACP
Portland State University
Oregon Physicians for Social Responsibility
With thanks to Rick North, Project Director, Campaign for Safe Food
Oregon Physicians for Social Responsibility
The Documented Health Risks of Genetically Engineered Foods (Long Version)Jack Olmsted
Content of the Presentation
Regulatory Failure: It is useful to explain how such dangerous products could have made it to the market with government approval. Several slides include quotes from formerly secret FDA documents that show how government policy was at odds with more cautious scientific opinion at the agency.
Health Risks of GMOs: This section highlights many of the adverse findings revealed through laboratory experiments and reported by farmers, doctors, and investigators. It also introduces some theoretical risks based on the current state of the science.
The Consumer Tipping Point: The final section includes a discussion of a strategy to achieve the tipping point of consumer rejection of GMOs in the US, which is the basis for our Campaign for Healthier Eating in America. The key elements needed are consumer education on GMO health risks combined with clear non-GMO choices.
The Institute for Responsible Technology http://www.responsibletechnology.org/resources/powerpoint-presentation-on-gmos
The Health Risks of Genetically Modified (GMO) Foods Jack Olmsted
The Health Risks of Genetically Modified short presentation.
The Institute for Responsible Technology is a world leader in educating policy makers and the public about genetically modified (GM) foods and crops. This fully-scripted PowerPoint can be powerful presentation tool to share online, in front of groups or one-on-one with a laptop, tablet, smartphone or paper printout.
http://www.responsibletechnology.org/resources/powerpoint-presentation-on-gmos
Brennan LaBrie, TIME For Kids Reporter, presentation at the Olympic Peninsula Tourism Summit 2009 - New Economy, Low Budget, High Tech, Growing Trends.
NOTE: On Friday October 16, an audio track will be added to this presentation.
Toxic effects of heavy metals : Lead and Arsenicsanjana502982
Heavy metals are naturally occuring metallic chemical elements that have relatively high density, and are toxic at even low concentrations. All toxic metals are termed as heavy metals irrespective of their atomic mass and density, eg. arsenic, lead, mercury, cadmium, thallium, chromium, etc.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxMAGOTI ERNEST
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
DERIVATION OF MODIFIED BERNOULLI EQUATION WITH VISCOUS EFFECTS AND TERMINAL V...Wasswaderrick3
In this book, we use conservation of energy techniques on a fluid element to derive the Modified Bernoulli equation of flow with viscous or friction effects. We derive the general equation of flow/ velocity and then from this we derive the Pouiselle flow equation, the transition flow equation and the turbulent flow equation. In the situations where there are no viscous effects , the equation reduces to the Bernoulli equation. From experimental results, we are able to include other terms in the Bernoulli equation. We also look at cases where pressure gradients exist. We use the Modified Bernoulli equation to derive equations of flow rate for pipes of different cross sectional areas connected together. We also extend our techniques of energy conservation to a sphere falling in a viscous medium under the effect of gravity. We demonstrate Stokes equation of terminal velocity and turbulent flow equation. We look at a way of calculating the time taken for a body to fall in a viscous medium. We also look at the general equation of terminal velocity.
ANAMOLOUS SECONDARY GROWTH IN DICOT ROOTS.pptxRASHMI M G
Abnormal or anomalous secondary growth in plants. It defines secondary growth as an increase in plant girth due to vascular cambium or cork cambium. Anomalous secondary growth does not follow the normal pattern of a single vascular cambium producing xylem internally and phloem externally.
Nucleophilic Addition of carbonyl compounds.pptxSSR02
Nucleophilic addition is the most important reaction of carbonyls. Not just aldehydes and ketones, but also carboxylic acid derivatives in general.
Carbonyls undergo addition reactions with a large range of nucleophiles.
Comparing the relative basicity of the nucleophile and the product is extremely helpful in determining how reversible the addition reaction is. Reactions with Grignards and hydrides are irreversible. Reactions with weak bases like halides and carboxylates generally don’t happen.
Electronic effects (inductive effects, electron donation) have a large impact on reactivity.
Large groups adjacent to the carbonyl will slow the rate of reaction.
Neutral nucleophiles can also add to carbonyls, although their additions are generally slower and more reversible. Acid catalysis is sometimes employed to increase the rate of addition.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
BREEDING METHODS FOR DISEASE RESISTANCE.pptxRASHMI M G
Plant breeding for disease resistance is a strategy to reduce crop losses caused by disease. Plants have an innate immune system that allows them to recognize pathogens and provide resistance. However, breeding for long-lasting resistance often involves combining multiple resistance genes
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
Dr. Lucija Tomljenovic, The biological basis for the neurotoxicity of vaccines
1. THE BIOLOGICAL BASIS FOR
THE NEUROTOXICITY OF
VACCINES
Lucija Tomljenovic, PhD
Neural Dynamics Research Group
Faculty of Medicine
University of British Columbia
2. Question...
WHY WOULD AN IMMUNE CHALLENGE
SUCH AS VACCINATION, AFFECT
BRAIN DEVELOPMENT AND/OR
FUNCTION ?
3. o “Until recently, the brain was studied almost exclusively by
neuroscientists and the immune system by immunologists,
fuelling the notion that these systems represented two
isolated entities.
o ....the crosstalk between these systems can no longer be
ignored and a new interdisciplinary approach is necessary.”
4. o Many proteins first identified in the immune system are also
expressed in the developing and adult nervous system.
Unexpectedly, recent studies reveal that a number of these
proteins, in addition to their immunological roles, are essential
for the establishment, function, and modification of synaptic
connections.
5. o “Recent studies demonstrate that immune molecules are present
at the right place and time to modulate the development and
function of the healthy and diseased central nervous system (CNS).
o “...functions for immune molecules during neural development
suggest that they could also mediate pathological responses to
chronic elevations of cytokines in neurodevelopmental disorders,
including autism spectrum disorders and schizophrenia.”
6. o “Despite the dogma that peripheral immune
responses could not affect CNS function under
normal circumstances, substantial evidence over the
past 10 years suggests that immune-CNS cross-talk
may be the norm rather than the exception.”
7. In: Handbook of Neurochemistry and Molecular Neurobiology:
A Lajtha, HO Besedovsky, A Galoyan (Eds), Springer, 2008.
o Because the communication between the immune system and
the brain occurs at multiple levels, this communication is now
defined as a “immune–neuroendocrine network.”
o The immune–neuroendocrine network plays a key role in:
‒ immune regulation
‒ brain function
‒ maintenance of general homeostasis
(circadian rhythms, endocrine and metabolic functions)
12. “Increased oxidative stress and immune dysregulation are present in
autism spectrum disorders.”
“We recently demonstrated the presence of neuroglial and innate
neuroimmune system activation in brain tissue and cerebrospinal fluid
of patients with autism, findings that support the view that
neuroimmune abnormalities occur in the brain of autistic patients and
may contribute to the diversity of the autistic phenotypes.”
13. o The evidence that changes in brain activity occur during the
immune response implies that signals released by immune cells
mediate these effects.
o peripheral immune insults can directly stimulate the synthesis of
pro-inflammatory cytokines (i.e., IL-1β, IL-6, TNF)-α within the
brain → brain inflammation
o It is clearly established that products derived from the immune
system, particularly cytokines, affect neuroendocrine functions.
− Laye et al. Mol Brain Res 1994; 27:157-162
− Besedovsky & Rey, Handbook of Neurochemistry and Molecular
Neurobiology, in: A. Lajtha, H.O. Besedovsky, A. Galoyan (Eds.), Springer,
2008
IMMUNE STIMULATION, IMMUNE CYTOKINES AND THEIR EFFECTS
ON BRAIN ACTIVITY
17. Is autism in part caused by a disruption of the
immune-neuroendocrine network
via elevation of pro-inflammatory mediators
(cytokines)?
18.
19. o We demonstrate an active neuroinflammatory process in the cerebral
cortex, white matter, and cerebellum of autistic patients.
o Immunocytochemical studies showed marked activation of microglia
and astroglia.
o Chemokines and cytokines MCP–1, IL-6 and TGF-1, derived from
neuroglia, were the most prevalent cytokines in brain tissues.
o Cerebrospinal fluid showed a unique proinflammatory profile of
cytokines, including a marked increase in MCP-1.
20. Which common peripheral immune insults other
than infections can induce the synthesis of
pro-inflammatory cytokines in the brain
and the activation of glial cells?
21.
22. Duplicating the pediatric vaccine schedule with
alum adjuvants in mice
2) Behavioral testing (social interaction) at 4-6 months of age
3) Sacrifice and collecting of brain tissue at 6 months of age
4) Semi-quantitative RT-PCR
5) Western blot for protein levels
Treatment Group
Mouse Age (days postnatal) Total Al injected
2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 (ug/kg body weight)
High aluminum
(US)
170 150 110 80 20 20 550
Low aluminum
(SCA)
90 80 50 20 240
Control (saline) X X X X X X 0
1) Aluminum injection schedule:
25. Genes affected in male mouse brains
Gene Function
NFKBIB NF-kappa-B inhibitor, which inhibits NF-kappa-B by complexing with,
and trapping it in the cytoplasm. NF-κB is the central regulator of
inflammation. Constitutive NF-κB activation is essential for
macrophage survival.
ACHE Neurotransmitter (Ach) degradative enzyme, acetylcholinesterase.
Anti-depression/anxiety effect. Low AChE activity is associated with
deficits in neurodevelopment, particularly in attention and memory.
CCL2/
MCP-1
Chemokine secreted by a few cell types including macrophage. A
cytokine involved in immunoregulatory and inflammatory processes.
IFNG Interferon gamma, a secreted product and potent activator of
macrophages. A soluble cytokine with antiviral, immunoregulatory and
anti-tumor properties.
TNF Tumor necrosis factor mainly secreted by macrophages.
Multifunctional proinflammatory cytokine.
27. BEHAVIORAL TESTS: LIGHT-DARK BOX
High aluminum group exhibits significantly increased anxiety &
reduced exploratory behavior. Females are more severely affected,
showing deficits even at low concentration of aluminum.
28. Males in the high aluminum group are significantly more lethargic
than those in the low aluminum group & control mice.
BEHAVIORAL TESTS: OPEN FIELD
30. REPEATED VACCINATIONS =
Stimulation of aberrant immune responses
Increased levels of inflammatory cytokines in the brain
IMPAIRED BRAIN DEVELOPMENT & FUNCTION
31. MOREOVER….
Repeated immunization with foreign antigen compounds
causes systemic autoimmunity in mice otherwise not
prone to spontaneous autoimmune diseases.
32. o CD4+ T cells from repeatedly-immunized mice acquire the
ability to induce autoantibodies which results in
autoimmune tissue injury similar to that seen in human
autoimmune diseases.
o “SYSTEMIC AUTOIMMUNITY APPEARS TO BE THE
INEVITABLE CONSEQUENCE OF OVER-STIMULATING THE
HOST’S IMMUNE ‘SYSTEM’ BY REPEATED IMMUNIZATION
WITH ANTIGEN.”
34. Otherreasons why vaccines tend to adversely affect
the centralnervous system
o Vaccine-derived aluminum persists in the body long after
injection (> 6 months)
o The alum adjuvant penetrates the blood-brain barrier carried by
macrophage cells. Once in the brain, alum has the potential to
trigger abnormal immuno-inflammatory reactions in the brain
34
35.
36. Penetration of the blood-brain barrier by aluminum can
allow access of antibodies to the brain and cause
unwanted autoimmune reactions
37. Testing the hypothesis:
Is there experimental evidence to indicate that
antibodies induced by the HPV vaccine cross-
react with neural antigens?
38. Gardasil
Mouse serum
Mouse brain
protein extract
Gardasil antigens
(HPV-16, 18, 11, 6)
Anti-HPV antibody
Anti – HPV antibody binds to HPV
Brain extract inhibits
Anti – HPV antibody
binding to HPV
Mouse serum
41. SUMMARY:
The neurotoxic risk of the HPV vaccine
o Neurotoxic action of the aluminum adjuvant
+
o Immuno-inflammatory effect of the HPV-16L1 vaccine
antigen
+
o Neuro-autoimmune effect of the cross-reactive HPV
vaccine-induced anti-HPV-16L1 antibody
41