This study investigated potential serological cross-reactivity between COVID-19 and dengue patients. Among 32 COVID-19 positive serum samples, no positive dengue virus (DENV) IgG/IgM results were observed. However, one false-positive result was observed among 44 DENV-positive serum samples tested for COVID-19 antibodies using two different rapid tests. While cross-reactivity between the viruses appears low based on this limited study, more data is needed on the accuracy of COVID-19 diagnostic tests, especially in regions where multiple tropical diseases are endemic.
COVID-19 (coronavirus disease 2019) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 novel coronavirus (2019-nCoV), a strain of coronavirus. The first cases were seen in Wuhan, China in December 2019 before spreading globally. The current outbreak was recognized as a pandemic on 11 March 2020.
The non-specific imaging findings are most commonly of atypical or organizing pneumonia, often with a bilateral, peripheral, and basal predominant distribution. No effective treatment or vaccine exists currently (March 2020).
Coronavirus Disease-19 and Reinfections: A Review of Casesasclepiuspdfs
Since first surfacing in Wuhan, China, in December 2019, the novel coronavirus disease-2019 (COVID-19) has led to a global pandemic with confirmed cases and death bells tolling in the millions with new cases still emerging daily. Despite sharing genetic similarities to the severe acute respiratory syndrome (SARS) virus, the specific viral proteins found on the novel SARS coronavirus 2 and its structure seems to make this strain much more elusive and destructive. Based on peer-reviewed cases, there seems to be an increase in patient reinfection, but due to current testing and treatment limitations, it is yet to be determined if the new trend of reinfection is due to a persistent COVID-19 infection that involves a latent period, a recurrent infection due to the same strain of COVID-19, or a mutated strain of COVID-19. The purpose of this study is to discuss the recent reports of the development of reinfection in previously confirmed COVID-19 cases in an attempt to gain a further understanding of the mechanisms of virulence, the effects on the human immune system, and how current testing and treatment modalities are faring. While the virus seems to have a penchant for patients with existing comorbidities, newer data indicate that everyone may be susceptible to possible infection and that not all patients will present with typical respiratory symptoms, making it imperative to examine established cases of reinfection in an attempt to further help with developing drugs for treatment, vaccines, and protocols for prevention.
COVID-19 (coronavirus disease 2019) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 novel coronavirus (2019-nCoV), a strain of coronavirus. The first cases were seen in Wuhan, China in December 2019 before spreading globally. The current outbreak was recognized as a pandemic on 11 March 2020.
The non-specific imaging findings are most commonly of atypical or organizing pneumonia, often with a bilateral, peripheral, and basal predominant distribution. No effective treatment or vaccine exists currently (March 2020).
Coronavirus Disease-19 and Reinfections: A Review of Casesasclepiuspdfs
Since first surfacing in Wuhan, China, in December 2019, the novel coronavirus disease-2019 (COVID-19) has led to a global pandemic with confirmed cases and death bells tolling in the millions with new cases still emerging daily. Despite sharing genetic similarities to the severe acute respiratory syndrome (SARS) virus, the specific viral proteins found on the novel SARS coronavirus 2 and its structure seems to make this strain much more elusive and destructive. Based on peer-reviewed cases, there seems to be an increase in patient reinfection, but due to current testing and treatment limitations, it is yet to be determined if the new trend of reinfection is due to a persistent COVID-19 infection that involves a latent period, a recurrent infection due to the same strain of COVID-19, or a mutated strain of COVID-19. The purpose of this study is to discuss the recent reports of the development of reinfection in previously confirmed COVID-19 cases in an attempt to gain a further understanding of the mechanisms of virulence, the effects on the human immune system, and how current testing and treatment modalities are faring. While the virus seems to have a penchant for patients with existing comorbidities, newer data indicate that everyone may be susceptible to possible infection and that not all patients will present with typical respiratory symptoms, making it imperative to examine established cases of reinfection in an attempt to further help with developing drugs for treatment, vaccines, and protocols for prevention.
Journal club covid vaccine neurological complications ZIKRULLAH MALLICK
the risks of adverse neurological events following SARS-CoV-2 infection are much greater than those associated with vaccinations, highlighting the benefits of ongoing vaccination programs.
Clinical and evolutionary features of SARS CoV-2 infection (COVID-19) in chil...komalicarol
Starting with December 2019 the medical world has faced a
new challenge as a consequence of a new type of coronavirus-2019-nCoV, similar to several familiar strains that determine
a comparable symptomatology (SARS- severe acute respiratory syndrome, MERS- Middle East severe acute respiratory syndrome), subsequently named SARS CoV-2, while the disease it
causes- COVID-19. The virus is of animal origin and through an
intermediate host (probably also a mammal) it suffered genetic
changes thus acquiring human cells receptors. In consequence,
SARS CoV-2 virus affects both children and even more frequently where it determines more severe clinical forms of disease. In
children, COVID-19 has various clinical forms, from asymptomatic ones to severe ones, complicated by multisystem inflammatory
syndrome (MIS-C Multisystem Inflammatory Syndrome – Child
or PIMS - TS (Paediatric Multisystem Inflammatory Syndrome
temporally associated with COVID-19) that sometimes can lead
to death
Corona viruses are a group of RNA viruses. In late December 2019, Patients with pneumonia with unknown etiology was get admitted in health care facilities in Wuhan, China, and resulted in a pandemic disease which affected more than 200 countries and responsible for 182,989 deaths world wide. The disease is officially named as Coronavirus Disease 2019 COVID 19, by WHO on February 11, 2020 . COVID 19 is a potential zoonotic disease with low to moderate estimated 2 -5 mortality rate. Currently, there is no definite treatment for COVID 19 although some trials are under investigation. Hence, appropriate use of PPE, regular hand hygiene, Respiratory and cough etiquettes, social distancing are some key elements to prevent the spread of disease. Ms. Pabalpreet Kaur | Ms. Eenu | Ms. Pooja Jaswal | Dr. (Mrs.) Jyoti Sarin "The Outbreak of COVID-19: An Overview" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-4 , June 2020, URL: https://www.ijtsrd.com/papers/ijtsrd30859.pdf Paper Url :https://www.ijtsrd.com/medicine/nursing/30859/the-outbreak-of-covid19-an-overview/ms-pabalpreet-kaur
To Assess the Severity and Mortality among Covid 19 Patients after Having Vac...YogeshIJTSRD
The severity and mortality of COVID 19 cases has been associated with the Three category such as vaccination status, severity of disease and outcome. Objective presently study was aimed to assess the severity and mortality among covid 19 patients. Methods Using simple lottery random method 100 samples were selected. From these 100 patients, 50 patients were randomly assigned to case group and 50 patients in control group after informed consents of relative obtained. Patients in the case group who being died after got COVID 19 whereas 50 patients in the control group participated who were survive after got infected from COVID 19 patients. Result It has three categories such as a Vaccination status For the vaccination status we have seen 59 patients were not vaccinated and 41 patients was vaccinated out of 100. b Incidence There were 41 patients were vaccinated whereas 59 patients were not vaccinated. c Severity In the case of mortality we selected 50 patients who were died from the Corona and I got to know that out of 50 patients there were 12 24 patients were vaccinated whereas 38 76 patients were non vaccinated. Although for the 50 control survival group total 29 58 patients were vaccinated and 21 42 patients was not vaccinated all graph start. Conclusion we have find out that those people who got vaccinated were less infected and mortality rate very low. Prof. (Dr) Binod Kumar Singh | Dr. Saroj Kumar | Ms. Anuradha Sharma "To Assess the Severity and Mortality among Covid-19 Patients after Having Vaccinated: A Retrospective Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45065.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/45065/to-assess-the-severity-and-mortality-among-covid19-patients-after-having-vaccinated-a-retrospective-study/prof-dr-binod-kumar-singh
Sanjay Mehta, MD
Associate Professor of Medicine
Division of Infectious Diseases & Global Public Health
Department of Medicine
University of California, San Diego
Characteristics of COVID-19 and Tuberculosis Co-Infection: A Cross-Sectional ...semualkaira
Coronavirus disease 2019 (COVID-19) and Tuberculosis (TB) are two major infectious diseases posing significant
public health threats. This study aimed to investigate the clinical
features of COVID-19 and TB co-infected patients.
A review on COVID-19, enlist all the details and information that i know about the current pandemic. i hope you found it informative. i am B.pharm student and currently searching for good job in Pharma Sector. if you want more presentation on any topic then i will deliver it to you, just take a step ahead and make a call on my phone number or you can whatsapp me. I always here to help.
Contact No. 8279242736
E.mail i'd : jain.gaurav402@gmail.com
Similarities and Differences between the New Coronavirus Infectious 2019 COVI...ijtsrd
From late fall to winter of 2020, the further challenge of medical care for thetwindemic of coronavirus infectious disease 2019 COVID 19 and seasonal influenza is imminent. The key to that is the ability of family doctors to protect the front lines of community medicine. It is difficult not only for patients but also for doctors to distinguish COVID 19 from seasonal flu only based on initial symptoms such as fever and malaise. Every year, patients with suspected seasonal flu are tested and, if positive, are treated with influenza drugs. However, due to the expansion of COVID 19, tests using a nasopharyngeal swab have a high risk of droplet infection. In this review, we would like to discuss the clinical similarities and differences between COVID 19 and seasonal influenza, including new findings.The coronavirus infectious disease 2019 COVID 19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of COVID 19, caused by severe acute respiratory syndrome coronavirus 2 SARS CoV 2 1 .The outbreak was first identified in December 2019 in Wuhan, China 2,3 .The World Health Organization WHO declared the outbreak a Public Health Emergency of International Concern on 30January 2020 and a pandemic on 11March 2020 4,5 .As of 30 August 2020,more than 25million cases of COVID 19 have been reported in more than 188 countries and territories, resulting in more than 843,000 deaths more than 16.4million people have recovered 6 .The WHO has published a report summarizing the differences between the COVID 19 and influenza 7 . Takuma Hayashi | Ikuo Konishi "Similarities and Differences between the New Coronavirus Infectious 2019 (COVID-19) and Seasonal Influenza" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, URL: https://www.ijtsrd.com/papers/ijtsrd33370.pdf Paper Url: https://www.ijtsrd.com/medicine/other/33370/similarities-and-differences-between-the-new-coronavirus-infectious-2019-covid19-and-seasonal-influenza/takuma-hayashi
It seems like you're providing information about the publication process of the International Journal of Advanced Publication Practices. This information outlines the fast publication schedule and peer-review process by the journal of the appears to prioritize a fast and efficient publication process while maintaining the quality and integrity of the research it publishes of the scopus.
Journal club covid vaccine neurological complications ZIKRULLAH MALLICK
the risks of adverse neurological events following SARS-CoV-2 infection are much greater than those associated with vaccinations, highlighting the benefits of ongoing vaccination programs.
Clinical and evolutionary features of SARS CoV-2 infection (COVID-19) in chil...komalicarol
Starting with December 2019 the medical world has faced a
new challenge as a consequence of a new type of coronavirus-2019-nCoV, similar to several familiar strains that determine
a comparable symptomatology (SARS- severe acute respiratory syndrome, MERS- Middle East severe acute respiratory syndrome), subsequently named SARS CoV-2, while the disease it
causes- COVID-19. The virus is of animal origin and through an
intermediate host (probably also a mammal) it suffered genetic
changes thus acquiring human cells receptors. In consequence,
SARS CoV-2 virus affects both children and even more frequently where it determines more severe clinical forms of disease. In
children, COVID-19 has various clinical forms, from asymptomatic ones to severe ones, complicated by multisystem inflammatory
syndrome (MIS-C Multisystem Inflammatory Syndrome – Child
or PIMS - TS (Paediatric Multisystem Inflammatory Syndrome
temporally associated with COVID-19) that sometimes can lead
to death
Corona viruses are a group of RNA viruses. In late December 2019, Patients with pneumonia with unknown etiology was get admitted in health care facilities in Wuhan, China, and resulted in a pandemic disease which affected more than 200 countries and responsible for 182,989 deaths world wide. The disease is officially named as Coronavirus Disease 2019 COVID 19, by WHO on February 11, 2020 . COVID 19 is a potential zoonotic disease with low to moderate estimated 2 -5 mortality rate. Currently, there is no definite treatment for COVID 19 although some trials are under investigation. Hence, appropriate use of PPE, regular hand hygiene, Respiratory and cough etiquettes, social distancing are some key elements to prevent the spread of disease. Ms. Pabalpreet Kaur | Ms. Eenu | Ms. Pooja Jaswal | Dr. (Mrs.) Jyoti Sarin "The Outbreak of COVID-19: An Overview" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-4 , June 2020, URL: https://www.ijtsrd.com/papers/ijtsrd30859.pdf Paper Url :https://www.ijtsrd.com/medicine/nursing/30859/the-outbreak-of-covid19-an-overview/ms-pabalpreet-kaur
To Assess the Severity and Mortality among Covid 19 Patients after Having Vac...YogeshIJTSRD
The severity and mortality of COVID 19 cases has been associated with the Three category such as vaccination status, severity of disease and outcome. Objective presently study was aimed to assess the severity and mortality among covid 19 patients. Methods Using simple lottery random method 100 samples were selected. From these 100 patients, 50 patients were randomly assigned to case group and 50 patients in control group after informed consents of relative obtained. Patients in the case group who being died after got COVID 19 whereas 50 patients in the control group participated who were survive after got infected from COVID 19 patients. Result It has three categories such as a Vaccination status For the vaccination status we have seen 59 patients were not vaccinated and 41 patients was vaccinated out of 100. b Incidence There were 41 patients were vaccinated whereas 59 patients were not vaccinated. c Severity In the case of mortality we selected 50 patients who were died from the Corona and I got to know that out of 50 patients there were 12 24 patients were vaccinated whereas 38 76 patients were non vaccinated. Although for the 50 control survival group total 29 58 patients were vaccinated and 21 42 patients was not vaccinated all graph start. Conclusion we have find out that those people who got vaccinated were less infected and mortality rate very low. Prof. (Dr) Binod Kumar Singh | Dr. Saroj Kumar | Ms. Anuradha Sharma "To Assess the Severity and Mortality among Covid-19 Patients after Having Vaccinated: A Retrospective Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45065.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/45065/to-assess-the-severity-and-mortality-among-covid19-patients-after-having-vaccinated-a-retrospective-study/prof-dr-binod-kumar-singh
Sanjay Mehta, MD
Associate Professor of Medicine
Division of Infectious Diseases & Global Public Health
Department of Medicine
University of California, San Diego
Characteristics of COVID-19 and Tuberculosis Co-Infection: A Cross-Sectional ...semualkaira
Coronavirus disease 2019 (COVID-19) and Tuberculosis (TB) are two major infectious diseases posing significant
public health threats. This study aimed to investigate the clinical
features of COVID-19 and TB co-infected patients.
A review on COVID-19, enlist all the details and information that i know about the current pandemic. i hope you found it informative. i am B.pharm student and currently searching for good job in Pharma Sector. if you want more presentation on any topic then i will deliver it to you, just take a step ahead and make a call on my phone number or you can whatsapp me. I always here to help.
Contact No. 8279242736
E.mail i'd : jain.gaurav402@gmail.com
Similarities and Differences between the New Coronavirus Infectious 2019 COVI...ijtsrd
From late fall to winter of 2020, the further challenge of medical care for thetwindemic of coronavirus infectious disease 2019 COVID 19 and seasonal influenza is imminent. The key to that is the ability of family doctors to protect the front lines of community medicine. It is difficult not only for patients but also for doctors to distinguish COVID 19 from seasonal flu only based on initial symptoms such as fever and malaise. Every year, patients with suspected seasonal flu are tested and, if positive, are treated with influenza drugs. However, due to the expansion of COVID 19, tests using a nasopharyngeal swab have a high risk of droplet infection. In this review, we would like to discuss the clinical similarities and differences between COVID 19 and seasonal influenza, including new findings.The coronavirus infectious disease 2019 COVID 19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of COVID 19, caused by severe acute respiratory syndrome coronavirus 2 SARS CoV 2 1 .The outbreak was first identified in December 2019 in Wuhan, China 2,3 .The World Health Organization WHO declared the outbreak a Public Health Emergency of International Concern on 30January 2020 and a pandemic on 11March 2020 4,5 .As of 30 August 2020,more than 25million cases of COVID 19 have been reported in more than 188 countries and territories, resulting in more than 843,000 deaths more than 16.4million people have recovered 6 .The WHO has published a report summarizing the differences between the COVID 19 and influenza 7 . Takuma Hayashi | Ikuo Konishi "Similarities and Differences between the New Coronavirus Infectious 2019 (COVID-19) and Seasonal Influenza" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, URL: https://www.ijtsrd.com/papers/ijtsrd33370.pdf Paper Url: https://www.ijtsrd.com/medicine/other/33370/similarities-and-differences-between-the-new-coronavirus-infectious-2019-covid19-and-seasonal-influenza/takuma-hayashi
It seems like you're providing information about the publication process of the International Journal of Advanced Publication Practices. This information outlines the fast publication schedule and peer-review process by the journal of the appears to prioritize a fast and efficient publication process while maintaining the quality and integrity of the research it publishes of the scopus.
Similar to Low risk of serological cross-reactivity between dengue and COVID-19.pdf (20)
CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
Telehealth psychology is a digital approach that offers psychological services and mental health care to clients remotely, using technologies like video conferencing, phone calls, text messaging, and mobile apps for communication.
QA Paediatric dentistry department, Hospital Melaka 2020Azreen Aj
QA study - To improve the 6th monthly recall rate post-comprehensive dental treatment under general anaesthesia in paediatric dentistry department, Hospital Melaka
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
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Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
The Healthy Ageing and Prevention Index is an online tool created by ILC that ranks countries on six metrics including, life span, health span, work span, income, environmental performance, and happiness. The Index helps us understand how well countries have adapted to longevity and inform decision makers on what must be done to maximise the economic benefits that comes with living well for longer.
Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
Low risk of serological cross-reactivity between dengue and COVID-19.pdf
1. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 115: e200225, 2020 1|2
online | memorias.ioc.fiocruz.br
SHORT COMMUNICATION
Low risk of serological cross-reactivity between dengue and COVID-19
Michele Spinicci1,2
/+
, Alessandro Bartoloni1,2
, Antonia Mantella1
,
Lorenzo Zammarchi1,2
, Gian Maria Rossolini1,3
, Alberto Antonelli1,3
1
University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
2
Careggi University Hospital, Infectious and Tropical Diseases Unit, Florence, Italy
3
Careggi University Hospital, Microbiology and Virology Unit, Florence, Italy
In the near future, the overlap of Coronavirus disease 2019 (COVID-19) and dengue epidemics is a concrete threat in tropical
regions. Co-epidemics of COVID-19 and dengue could be an overwhelming challenge for health systems in low- and middle-
income countries. In this work, we investigated potential serological cross-reactions between COVID-19 and dengue patients.
Among 32 COVID-19 positive sera, no positive Dengue virus (DENV) IgG/IgM results were observed. On the other hand, one
false-positive result was observed among 44 DENV-positive sera tested for COVID-19 antibodies with each of the two rapid tests
used. Further data on accuracy of COVID-19 diagnostic test are urgently warranted.
Key words: COVID-19 - SARS-CoV-2 - dengue - antibodies
doi: 10.1590/0074-02760200225
Financial support: This article has been supported by funds of Ministry of
Education, University and Research (Italy) Excellence Departments 2018-2022
(Project for the Department of Experimental and Clinical Medicine).
+ Corresponding author: michele.spinicci@unifi.it
https://orcid.org/0000-0002-5377-7118
Received 10 May 2020
Accepted 04 August 2020
Since December 2019, Coronavirus disease 2019 (CO-
VID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), emerged in the interna-
tional scene as a major public health concern. COVID-19
pandemic is having a disrupting impact on health systems
throughout Asia, Europe and America.(1)
At the same time,
a large outbreak of dengue is ongoing in Latin American
countries, with several deaths being recorded.(2)
In the near future, the overlap of COVID-19 and den-
gue epidemics is a concrete threat in tropical regions.(3,4)
COVID-19 and dengue share several features of clini-
cal and laboratory presentation, and differential diagno-
sis should rely on specific diagnostic tests.(5)
Recently,
two cases of false-positive results by rapid diagnostic
test (RDT) for dengue in patients with SARS-CoV-2
infection were reported from Singapore.(6)
If serological
cross-reactivity between patients with COVID-19 and
dengue will be confirmed, it may result in a high num-
ber of misdiagnoses, with dangerous consequences both
from the patients and from public health point of view.(7)
In order to further explore this possibility, we in-
vestigated potential serological cross-reactions be-
tween COVID-19 and dengue patients, by performing
commercial assays for detection of anti-Dengue virus
(DENV) and anti-SARS-CoV-2 antibodies on sera from
well-characterised COVID-19- and dengue-positive pa-
tients, respectively.
A total of 32 anonymised sera, obtained from symp-
tomatic patients with COVID-19 diagnosed by positive
anti-SARS-CoV-2 IgM/IgG (32/32, tested by 2019-
NCOV IgG/IgM Rapid Test Cassette, ScreenItalia, Peru-
gia, Italy) and/or RT-PCR for SARS-CoV-2 on nasopha-
ryngeal swab (26/32), were tested by Dengue Enzyme
Linked Immune Assay (ELISA) DENV IgG-IgM (VIR-
CELL, Granada, Spain). Sera were collected and tested
in Italy, at the Careggi University Hospital of Florence,
where dengue is not endemic, and previous exposure to
DENV was unlikely.
Moreover, 44 anonymised DENV-positive sera, from
cases of acute dengue (27 of whom confirmed by NS1 an-
tigen positivity, plus 17 probable diagnosis with only IgM
and IgG positivity), were tested by using COVID-19 IgG/
IgM Rapid Test Cassette (Orient Gene, Zhejiang, China)
and 2019-NCOV IgG/IgM Rapid Test Cassette (ScreenI-
talia, Perugia, Italy). All DENV-positive sera were col-
lected from travellers, before SARS-CoV-2 emergence.
Among 32 COVID-19 positive sera, no positive
DENV IgG/IgM results were observed. On the other
hand, one false-positive result was observed among 44
DENV-positive sera tested for COVID-19 antibodies
with each method (in one case for IgG and IgM, and in
another for IgG only), in two different samples.
Serological test for dengue are known to be affected
by cross-reactivity issues in areas were multiple Flavivi-
rus, such as Zika, Yellow fever or Japanese encephalitis
virus are circulating. The risk of false-positive results
is reduced when dengue IgM/IgG testing is paired with
NS1 antigen capture.(8)
According with our results, the concern about false-
positive dengue serology in COVID-19 patients could
be downsized, at least when an ELISA is used. On the
other hand, COVID-19 false-positive results are possi-
ble in patients with DENV infection, although at a low
rate and variably using different RDTs for COVID-19.
It should be also considered that these COVID-19 false-
positive results may reflect different aspecific cross-
reactivity, not necessarily related to DENV-specific
antibodies.(9)
Of course, this is a preliminary study on a
limited number of samples, which need to be validated
on a wider population.
2. Michele Spinicci et al.
2|2
In low- and middle-income countries, where arbovi-
ruses and other common tropical diseases are highly en-
demic, SARS-CoV-2 spread will represent an additional
challenge for clinicians.(10,11)
In particular, co-epidemics
of COVID-19 and dengue could be an overwhelming
situation for health systems.(12)
Further studies are war-
ranted to better elucidate the accuracy of commercially
available RDTs for SARS-CoV-2 antibodies detection
and their role within the strategy for COVID-19 diagno-
sis and control.
AUTHORS’ CONTRIBUTION
MS, AB, LZ and GMR contributed to the study design; AA
and AM performed laboratory tests. All authors contributed to
data analysis, interpretation and critically reviewed the paper.
REFERENCES
1. WHO - World Health Organization. Coronavirus disease (CO-
VID-2019) situation reports. 2020. Available from: https://www.
who.int/emergencies/diseases/novel-coronavirus-2019/situation-
reports/ Last access: 23rd June 2020.
2. PAHO/WHO - Pan American Health Organization/World Health
Organization. Epidemiological update: arbovirus. Washington,
DC: PAHO/WHO; 2020.
3. Navarro JC, Arrivillaga-Henríquez J, Salazar-Loor J, Rodriguez-
Morales AJ. COVID-19 and dengue, co-epidemics in Ecuador and
other countries in Latin America: pushing strained health care
systems over the edge. Travel Med Infect Dis. 2020; 101656. [pub-
lished online ahead of print].
4. Lorenz C, Azevedo TS, Chiaravalloti-Neto F. COVID-19 and
dengue fever: a dangerous combination for the health system in
Brazil. Travel Med Infect Dis. 2020; 35: 101659.
5. Lam LTM, Chua YX, Tan DHY. Roles and challenges of primary
care physicians facing a dual outbreak of COVID-19 and den-
gue in Singapore. Fam Pract. 2020; cmaa047. [published online
ahead of print].
6. Yan G, Lee CK, Lam LTM, Yan B, Chua YX, Lim AYN, et al. Co-
vert COVID-19 and false-positive dengue serology in Singapore.
Lancet Infect Dis. 2020; 20(5): 536.
7. Li R, Pei S, Chen B, Song Y, Zhang T, Yang W, et al. Substantial
undocumented infection facilitates the rapid dissemination of nov-
el coronavirus (SARS-CoV2). Science. 2020; 368(6490): 489-93.
8. Muller DA, Depelsenaire AC, Young PR. Clinical and laboratory
diagnosis of dengue virus infection. J Infect Dis. 2017; 215(Suppl.
2): S89-S95.
9. Sethuraman N, Jeremiah SS, Ryo A. Interpreting diagnostic tests
for SARS-CoV-2. JAMA. 2020; 10.1001/jama.2020.8259. [pub-
lished online ahead of print].
10. Bokhari SMMA, Mahmood F, Bokhari SMSA. Case report: di-
agnosis of novel Coronavirus disease (COVID-19) versus tropical
diseases in Pakistan. Am J Trop Med Hyg. 2020; 103(1): 77-8.
11. Joob B, Wiwanitkit V. COVID-19 can present with a rash and be
mistaken for dengue. J Am Acad Dermatol. 2020; 82(5): e177.
12. Wu D, Lu J, Liu Q, Ma X, He W. To alert co-infection of SARS-
COV-2 and dengue virus in developing countries in the dengue-
endemic area. Infect Control Hosp Epidemiol. 2020; 1. [published
online ahead of print].