The document provides an overview of large language models and their applications in healthcare. It discusses the evolution of LLMs from DNNs to transformers, surveys current prominent models like GPT-4, and examines ways of extending LLMs through frameworks, tools and agents. The document also explores potential medical research applications of LLMs, such as assisting with medical education, patient communication and dialog. It analyzes LLM performance on medical question answering benchmarks and notes the need for human supervision when applying LLMs in healthcare. Finally, the document briefly mentions the rise of MedTech startups leveraging LLMs.