1) In 1979-1981, tensions emerged between Alza and Ciba-Geigy regarding control over projects, information sharing, and Alza's financial situation.
2) By 1981, Ciba-Geigy scientists felt they knew as much about drug development using Alza's systems as Alza, but information sharing between the companies remained limited.
3) Alza was still operating at a loss and projecting a need for additional capital, bringing its relationship with Ciba-Geigy under review.
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3. Evolution of the Project Portfolio: 1979
• In 1979 TTS Scopolamine moved into Phase 3 clinical
trails and became a “Ciba-Geigy project”
• OROS Theophylline dropped before clinical testing
• IND filed for TTS Nitroglycerin
• In general: “Ciba-Geigy had become aware that Alza’s
systems, in particular OROS, were not suitable for
immediate use with a wide range of compounds…. As a
result, much more emphasis began to be placed on basic…
research….”
4. Emerging Tensions: 1979
• Alza presents a number of proposals for third party contracts to ARAT.
ARAT “consistently complained that these were phrased too
generally” while Alza “claimed that detailed proposals would yield
information on competitors” -- 75% of proposals eventually approved
but with very substantial delays
• Alza personnel wanting quick decisions tend to bypass the Ciba-Geigy
hierarchy. “As a result, a lot of activity by-passed the liaison desks…
misunderstandings occurred which many at Ciba-Geigy felt must have
been deliberately induced”
• Alza complained that information on the behavior of systems in
clinical trials run by Ciba-Geigy was not getting through to them
• Ciba-Geigy complained that Alza was publishing articles which gave
away information that should be restricted
• Alza financial situation precarious. Projected cumulative cash deficit
of $57m between 1981 and 1986
5. 1979 Alza Restructuring
• All manufacturing consolidated into a single building, sale of vacated
premises.
• Money raised ($8m) was used to reduce the $20m bank debt, reducing
interest payments.
• Alza was encouraged to raise new funds through third-party research
contracts.
• All deviations of more than 10% from project budget must be
authorized by the JRB. “Underspending was taken as an indication of
lack of commitment.”
• Revised form of standard quarterly progress report demanded of Alza
project leaders with “milestone” reports charting progress against
objectives.
• Research conferences abandoned. Partly replaced with project specific
conferences.
6. Project Progress: 1981
• TTS Scopolamine testmarketed in Florida, ready for US
launch
• TTS Nitroglycerin and Estradiol ready for final testing:
but CG sponsors refuse to hand them over to CG for final
testing and handle final testing themselves in conjunction
with Alza personnel.
• Both sponsors are “scientists of some standing” and remain
“unaffected by the complaints of the departments that
(they) bypassed.”
• No Oros projects in clinical trials. All are in direct
competition with existing Ciba-Geigy products and are
being managed through conventional Ciba-Geigy channels
7. Evolution of the Project Portfolio: 1981
• Non drug-specific research took only 10% of Alza’s
budget in 1978 but nearly 50% in 1981.
• ARAT felt that Alza’s resources were being spread far too
thin and that they needed to focus their efforts more
tightly.
• Alza complained that its research resources were not being
fully occupied.
8. Information Flow and Technology Transfer
• By 1981 “Ciba-Geigy scientists… felt that they knew as
much as Alza about the testing and development of new
drugs in Oros and TTS systems and considerably more
than Alza about scale-up to production.”
• Alza was demanding details of CG’s progress, but CG was
concerned that despite confidentiality obligations, the
knowledge would be used by Alza with CG’s competitors.
• “Neither side could be said to be completely open to the
other. Progress reports were exchanged which were
clearly designed to pass on as little information as
practical.” (With TTS-Nitro as a major exception.)
9. Alza’s Financial Position and Prospects: 1981
• Annual operating losses $5-6m.
• Of cumulative sales projected 1978-1980 of $43m, only $8m realized.
• Third party contracts yielded only $3m in 1981.
• Sales of TTS Nitroglycerin and Scopolamine through 1987 should be
about $626m and will yield royalties of around $23m.
• Alza unlikely to be profitable until 1984, and estimated a requirement
for additional capital of $6-10m over the next three years.
• Outside investors potentially interested since ADDS increasingly
accepted in the market place, but position with Ciba-Geigy needs to be
clarified.
10. The Alza / Ciba-Geigy Decision:
• Should Ciba-Geigy make further investments in ADDS?
• If so, was Alza the appropriate vehicle for this investment?
• If so, what support should be offered under what
conditions?
• If not, how should the withdrawal be arranged so as to
preserve the interests of both Ciba-Geigy and the other
stockholders?
• What is Alza’s preferred option?
• How much independence does Alza prefer?
11. Negotiation:
• Should the relationship continue? (If so, how? What
are the new terms of the relationship?) (If not, then
how to exit?)
• Some things to think about:
– financial arrangements…stock, costs, royalties…over
time
– projects/drugs to focus on
– organizational arrangements
– people
• Will this be successful? Define success. What’s the
likelihood of success for your firm? For theirs?