This document discusses how to differentiate instruction using technology to meet the needs of diverse students. It describes differentiated instruction and universal design for learning approaches. The GAME plan framework is introduced for setting goals, taking action, monitoring understanding, and evaluating learning. The use of technology, such as audiobooks or alternative assignments, allows flexibility. Learning profiles can help identify students' strengths using Gardner's multiple intelligences. Assistive technology is defined and its importance discussed, ranging from low-tech to high-tech devices. Equitable access to technology and understanding student culture are important considerations.