The document discusses the third stage of labor and management of postpartum hemorrhage. It describes the third stage as the period from delivery of the fetus to delivery of the placenta and membranes. Active management of the third stage with prophylactic uterotonics like oxytocin and controlled cord traction is recommended to reduce blood loss and duration. Postpartum hemorrhage is a major complication that can be life-threatening, so risk factors should be identified and prophylaxis with uterotonics given to all women during the third stage of labor.
physiology and management of third stage of labourPRANATI PATRA
OBSTETRICS & GYNAECOLOGICAL NURSING
physiology and management of third stage of labour-introduction
labour
stages of labor
physiology
management of third stage of labour.
Uterine contractions continue, although less frequently than in the second stage.
The uterus contracts and becomes smaller and, as a result, the placenta separates.
The placenta is squeezed out of the upper uterine segment into the lower uterine segment and vagina. The placenta is then delivered.
The contraction of the uterine muscle compresses the uterine blood vessels and this prevents bleeding. Thereafter, clotting (coagulation) takes place in the uterine blood vessels due to the normal clotting mechanism.
physiology and management of third stage of labourPRANATI PATRA
OBSTETRICS & GYNAECOLOGICAL NURSING
physiology and management of third stage of labour-introduction
labour
stages of labor
physiology
management of third stage of labour.
Uterine contractions continue, although less frequently than in the second stage.
The uterus contracts and becomes smaller and, as a result, the placenta separates.
The placenta is squeezed out of the upper uterine segment into the lower uterine segment and vagina. The placenta is then delivered.
The contraction of the uterine muscle compresses the uterine blood vessels and this prevents bleeding. Thereafter, clotting (coagulation) takes place in the uterine blood vessels due to the normal clotting mechanism.
about the process of third stage of labor and management of post Partum Hemorrhage ,which is one of the major causes of blood loss in a pregnant women that needs active management.
NURSING MANAGEMENT OF THIRD AND FOURTH STAGE OF LABOUR.docx.pptxAyushi958023
In this ppt you will learn about Nursing management of third stage of labor(expected and active management) and Nursing management fourth stage of labor.
Pathophysiology of Normal Labor:
A series of events that take place in female genital organs to expel the product of conception that are fetus, placenta, membranes) out of womb through the vagina into the outer world. We further describe pathogenesis and features of different stages of labor
Active Management of Third Stage of LaborAzael Haward
This short presentation gives a short overview of AMTSL, showing its evolution, advantages and illustrated steps.
AMTSL its a single important step you can do to reduce maternal death secondary to Post partum Hemorrhage.
Stages of normal labor- easy explanation for Nursing Students(B.Sc & GNM)...
Introduction, definition of normal labor, definition of normal labor by WHO, Mechanism of labor, stages of labor, Intrapartum management of Labor, pain control.
about the process of third stage of labor and management of post Partum Hemorrhage ,which is one of the major causes of blood loss in a pregnant women that needs active management.
NURSING MANAGEMENT OF THIRD AND FOURTH STAGE OF LABOUR.docx.pptxAyushi958023
In this ppt you will learn about Nursing management of third stage of labor(expected and active management) and Nursing management fourth stage of labor.
Pathophysiology of Normal Labor:
A series of events that take place in female genital organs to expel the product of conception that are fetus, placenta, membranes) out of womb through the vagina into the outer world. We further describe pathogenesis and features of different stages of labor
Active Management of Third Stage of LaborAzael Haward
This short presentation gives a short overview of AMTSL, showing its evolution, advantages and illustrated steps.
AMTSL its a single important step you can do to reduce maternal death secondary to Post partum Hemorrhage.
Stages of normal labor- easy explanation for Nursing Students(B.Sc & GNM)...
Introduction, definition of normal labor, definition of normal labor by WHO, Mechanism of labor, stages of labor, Intrapartum management of Labor, pain control.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
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Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Labor
• Physiological process
• The products of conception passed form uterus to
outside world
• Normal labour: spontaneous in onset, at term, vertex
presentation, natural termination without any
complications affecting health of mother &/or
newborn
• Three stages of labor
3. Third stage: events
• After expulsion of fetus to expulsion of
placenta & membranes (afterbirths)
• Duration :15 min.(primigravida multigravida)
• AMTSL:5 minutes
• Placental separation
• Placental expulsion
4. Methods of placental separation
Central ( Schultze) separation
Marginal (Mathews Duncan) separation
5.
6. Expulsion of placenta
• Contraction & retraction of Upper Uterine
Segment
• Placenta forced to lie in LUS/upper vagina
• Voluntary contraction of abdominal muscles
• Expulsion of placenta
7. Mechanisms to control bleeding
1. Effective retraction of
uterine muscles :
Living ligatures
2. Thrombosis of torn
sinuses
3. Myotamponade:
apposition of walls of
the uterus
8. Management of third stage
• Most crucial stage
• Strict vigilance
• Follow protocols
• Expectant management
• Active management
9. Expectant management
• Look for 3 classic signs of placental separation
– Lengthening of U. cord
– A gush of blood from vagina signifying separation
of placenta from uterine wall
– Change in shape of uterine fundus from discoid to
globular with elevation of fundal height
• Spontaneous/Controlled cord traction (CCT)
• Expulsion of placenta :20 minutes
10. Expectant management
• Massage the uterus
• Intramuscular Oxytocin : 10 IU
• Examination of placenta ,membranes, cord
• Inspect vulva, vagina & perineum
11. CCT
• Modified Brandt Andrews method
• Left hand: palmar surface of fingers placed above
pubic symphysis. Body of uterus pushed upwards
& backwards
• Right hand: cord traction in downward &
backward direction
• Uterus feels hard, contracted
16. Active management
• AMTSL: Active Management of Third Stage of Labour
– Prophylactic uterotonic after delivery of baby
( Oxytocin 10 IU ,IM)
– cord clamping, cutting & Controlled cord traction
of U cord
– Uterine massage
• Excites powerful uterine contractions ,aid in early
placental separation, minimises blood loss &
duration of third stage (5 min.)
17. Third stage
• Most crucial
• Life threatening complications
• PPH(postpartum haemorrhage)
• Retained placenta
• Inversion of uterus
• Pulmonary embolism
19. PPH: hard facts
• Globally in 10-11% women having live births
• Duration between onset of massive bleeding
& death: 2 hours
• 14 million women worldwide
• 1.4 million women die annually
• India : 15-25% of maternal deaths due to PPH
24. Prophylaxis of PPH
• Improvement of health status of mother(Hb>11gm%)
• Identify high risk women
• Plan for institutional delivery /SBA
• Strict vigilance of all women in 3rd stage labor
• Practice AMTSL in all
• Examination of afterbirths ,should be a routine
• Explore Uterovaginal canal following difficult/
instrumental, destructive delivery
29. WHO guidelines
• Give uterotonics routinely during 3rd stage labor, in
all births
• Oxytocin 10 IU IM is drug of choice
• Use other uterotonics only when Oxytocin is not
available
• Late cord clamping( 1-3 min after birth) is
recommended
• Early cord clamping (<1min of birth): not
recommended until the neonate is asphyxiated &
needs immediate resuscitation
30. MCQ1
• Labor is said to be normal if all are present
except:
1. At term
2. Breech presentation
3. Spontaneous in onset
4. Healthy mother & neonate after delivery
31. MCQ1
• Labor is said to be normal if all are present
except:
1. At term
2. Breech presentation
3. Spontaneous in onset
4. Healthy mother & neonate after delivery
32. MCQ2
• Regarding the third stage of labor, following is
not true:
1. Most crucial stage of labor
2. Duration is 15 minutes
3. Uterine inversion is most common
complication
4. AMTSL is routine in all
33. MCQ2
• Regarding the third stage of labor, following is
not true:
1. Most crucial stage of labor
2. Duration is 15 minutes
3. Uterine inversion is most common
complication
4. AMTSL is routine in all
34. MCQ3
• The uterotonic of choice for prophylaxis of
PPH in third stage of labor is
1. Syntometrine
2. Oxytocin
3. Misoprostol
4. carboprost
35. MCQ3
• The uterotonic of choice for prophylaxis of
PPH in third stage of labor is
1. Syntometrine
2. Oxytocin
3. Misoprostol
4. carboprost
36. MCQ4
• All are true in relation to AMTSL except:
• 10 IU of Oxytocin , IM
• Uterine massage
• Reduces the duration of third stage
• Perform in only high risk cases
37. MCQ4
• All are true in relation to AMTSL except:
1. 10 IU of Oxytocin , IM
2. Uterine massage
3. Reduces the duration of third stage
4. Perform in only high risk cases
38. MCQ5
• Complications during third stage of labor are
all except
1. PPH
2. Chronic Uterine inversion
3. Retained placenta
4. Amniotic fluid embolism
39. MCQ5
• Complications during third stage of labor are
all except
1. PPH
2. Chronic Uterine inversion
3. Retained placenta
4. Amniotic fluid embolism
40. MCQ6
• The most frequently observed method of
placental separation :
1. Marginal separation
2. Central separation
3. None
4. both
41. MCQ6
• The most frequently observed method of
placental separation :
1. Marginal separation
2. Central separation
3. None
4. both
42. MCQ7
• The most important method to control
uterine bleeding following delivery
1. Myotamponade
2. Thrombosis
3. Contraction& retraction of uterine muscle
4. none
43. MCQ7
• The most important method to control
uterine bleeding following delivery
1. Myotamponade
2. Thrombosis
3. Contraction& retraction of uterine muscle
4. none
44. MCQ8
• Following are true regarding misoprostol,
except
1. Low cost
2. Easy storage
3. Administered rectally
4. Drug of choice for AMTSL
45. MCQ8
• Following are true regarding misoprostol,
except
1. Low cost
2. Easy storage
3. Administered rectally
4. Drug of choice for AMTSL
46. MCQ9
• Following is true regarding Oxytocin
1. Given as IV bolus dose
2. Thermolabile
3. Contraindicated in cardiac patient
4. Causes hypertension
47. MCQ9
• Following is true regarding Oxytocin
1. Given as IV bolus dose
2. Thermolabile
3. Contraindicated in cardiac patient
4. Causes hypertension
48. MCQ10
• Prevention of PPH, all are true except
1. Treatment of anemia in antenatal period
2. Practice AMTSL in all
3. Home delivery in high risk cases
4. In forceps delivery, explore uterovaginal canal
49. MCQ10
• Prevention of PPH, all are true except
1. Treatment of anaemia in antenatal period
2. Practice AMTSL in all
3. Home delivery in high risk cases
4. In forceps delivery, explore uterovaginal canal