2. Definition
A reduction in the concentration of
hemoglobin in the peripheral blood below
the normal for the age and sex of the patient
Male 13 g/dl
Female 11 g/dl
7. Macrocytic Anemia
Blood & BM Morphology
Hemolytic An Alcoholism
Hemorrhage Hepatic dis.
MDS
Non-Megaloblatic
Clinical data; serum vitamins
Folate Deficiency Reticulocytes
No deficiency
B12 deficiency
N /Decreased
Increased
Hypothyroidism
Congenital
Drugs
Schilling test
with IF
Diet
Corrected Not Corrected
Good Poor
Megaloblatic
8. Microcytic anemia
Microcytic anemias usually as result of
defective hemoglobin synthesis
Differential:
ā¢ Iron deficiency
ā¢ Thalassemia trait
ā¢ Anemia of chronic disease
ā¢ Sideroblastic anemia
9. Iron Deficiency vs Thalassemia
Hb MCV RDW
Thalassemia Normal/Slight
ly decreased 65 Normal
Fe
deficiency
Decreased 65 Increased
10. Hypochromic & /or Microcytic Anemia
Serum Iron
Thalassemia Sideroblastic An
Hemoglobino
pathies
Congenital
Acquired
Iron
deficiency
Normal Increased
Reduced
Hb Electrophoresis BM sideroblastic Fe
increased
S Ferritin
BM Iron
An of
chronic
disorders
Low
Normal or
increased
Increased
Absent