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By: Izatty Lim
(0308188)
Definition
Cellular mechanism of muscle fatigue & recovery
 decline in muscle performance associated with muscle
activity.
 As fatigue sets in,
o force in your muscles reduces,
o muscle responses to brain stimuli reduces
o activity levels decrease.
 temporary and reversible condition
continuous high-frequency
stimulation
repeated tetanic
stimulation
Fatigue mechanisms have been found to be multifactorial.
Fuel depletion Metabolic by-products Neuromuscular events
•Intramuscular ATP
• Muscle glycogen
• Blood glucose
• Hydrogen ions (H+) in
plasma and muscle
• Inorganic phosphate
(Pi)
• Adenosine diphosphate
(ADP)
• Decreased ‘firing’ of the
central nervous system
• Impaired sodium (Na+)
and potassium (K+)
gradients
Problem:
build up of
lactic acid
Problem:
needs oxygen
Problem: only make
1 ATP at a time
(15-20s of activity)
Ca2+
 Myosin: for cross-bridge cycling
 Ca2+ ATPase:
o terminate contraction, pump Ca2+ back into sarcoplasmic reticulum
 reduced maximum force-generating capacity
 reduced myofibrillar Ca2+ sensitivity
 reduced Ca2+ release
↓ force
• ACIDOSIS
• H+ competes with Ca2+ for binding sites on troponin C
• ↓ maximal Ca2+ activated force and Ca2+ sensitivity (slows the maximal
shortening velocity and prolongs relaxation)
• Burning sensation
Predominant
energy system
Likely causes of fatigue Types of recovery
ATP/PC Fuel Depletion:
 ATP & PC
Rest recovery
Lactic Acid Accumulation of metabolic by-
products:
 H+ (hydrogen ions)
 Pi (inorganic phosphates)
Non-dietary
Active Recovery
Massage
Hydro/water based therapies
e.g. contrasting via hot/cold baths
Aerobic Fuel Depletion:
 Glycogen stores, then fats
Elevated body temperature leading to:
 Dehydration
Dietary
High Glycemic Index foods
Rehydration
Non-dietary
Active Recovery
Massage
Hydro/water based therapies
 http://www.ncbi.nlm.nih.gov/pubmed/18195089
 http://www.mendeley.com/catalog/cellular-mechanisms-
muscle-fatigue/
 http://lib.bioinfo.pl/pmid:7576593
 http://www.pc.maricopa.edu/Biology/thoffman/Co
mmon201/MuscularSystem.pdf
Skeletal Muscle Fatigue and Cellular Mechanisms

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Skeletal Muscle Fatigue and Cellular Mechanisms

  • 1.   By: Izatty Lim (0308188)
  • 2. Definition Cellular mechanism of muscle fatigue & recovery
  • 3.  decline in muscle performance associated with muscle activity.  As fatigue sets in, o force in your muscles reduces, o muscle responses to brain stimuli reduces o activity levels decrease.  temporary and reversible condition continuous high-frequency stimulation repeated tetanic stimulation
  • 4. Fatigue mechanisms have been found to be multifactorial.
  • 5. Fuel depletion Metabolic by-products Neuromuscular events •Intramuscular ATP • Muscle glycogen • Blood glucose • Hydrogen ions (H+) in plasma and muscle • Inorganic phosphate (Pi) • Adenosine diphosphate (ADP) • Decreased ‘firing’ of the central nervous system • Impaired sodium (Na+) and potassium (K+) gradients
  • 6. Problem: build up of lactic acid Problem: needs oxygen Problem: only make 1 ATP at a time (15-20s of activity) Ca2+
  • 7.  Myosin: for cross-bridge cycling  Ca2+ ATPase: o terminate contraction, pump Ca2+ back into sarcoplasmic reticulum
  • 8.
  • 9.  reduced maximum force-generating capacity  reduced myofibrillar Ca2+ sensitivity  reduced Ca2+ release ↓ force
  • 10. • ACIDOSIS • H+ competes with Ca2+ for binding sites on troponin C • ↓ maximal Ca2+ activated force and Ca2+ sensitivity (slows the maximal shortening velocity and prolongs relaxation) • Burning sensation
  • 11.
  • 12. Predominant energy system Likely causes of fatigue Types of recovery ATP/PC Fuel Depletion:  ATP & PC Rest recovery Lactic Acid Accumulation of metabolic by- products:  H+ (hydrogen ions)  Pi (inorganic phosphates) Non-dietary Active Recovery Massage Hydro/water based therapies e.g. contrasting via hot/cold baths Aerobic Fuel Depletion:  Glycogen stores, then fats Elevated body temperature leading to:  Dehydration Dietary High Glycemic Index foods Rehydration Non-dietary Active Recovery Massage Hydro/water based therapies
  • 13.  http://www.ncbi.nlm.nih.gov/pubmed/18195089  http://www.mendeley.com/catalog/cellular-mechanisms- muscle-fatigue/  http://lib.bioinfo.pl/pmid:7576593  http://www.pc.maricopa.edu/Biology/thoffman/Co mmon201/MuscularSystem.pdf