This document contains the resume of Iyappan M, summarizing his educational qualifications, work experience, skills, and references. He has over 8 years of experience in process R&D and medicinal chemistry R&D at Orchid Chemicals and Pharmaceuticals and Shasun Chemicals and Pharmaceuticals. He has worked on developing processes for several drugs including ceftazidime, imipenem, meropenem, and currently works on sapropterin dihydrochloride. He has expertise in analytical techniques like NMR, IR, mass spectrometry and handling various reagents.

1. IYAPPAN.M
9/708, Third St, Sivagami Nagar, Medavakkam, Chennai-600100
Contact.No: 9884946055, 9942206055, E-mail: iyapps_123@yahoo.com
CAREER OBJECTIVE:
To pursue a challenging career and to be a part of your esteemed organization that gives the scope to
enhance my knowledge, skills and to reach the pinnacle in the field with sheer dedication and smart work.
EDUCATIONAL PROFILE:
QUALIFYING EXAM
SCHOOL/UNIVER
SITY
YEAR PERCENTAGE / CLASS
M.Sc Chemistry
MS UNIVERSITY 2005-2007 74.8 / FIRST
B.Sc Chemistry
MS UNIVERSITY 2002-2005 83.5 / FIRST
HSC(TNHSB)
ICI GOVT BOYS HSS 2000-2002 82.5 / FIRST
SSLC(Matric)
HILTON MATRIC HSS 2000 85.6 / FIRST
CAREER PROFILE:
ORGANISATION DEPARTMENT YEAR
ORCHID CHEMICALS AND
PHARMACEUTICALS
CEPHALOSPORINS PROCESS
DEVELOPMENT
2007 TO 2011
ORCHID CHEMICALS AND
PHARMACEUTICALS CRAMS 2011 TO 2012
ORCHID CHEMICALS AND
PHARMACEUTICALS
CEPHALOSPORINS NEW DRUG
DISCOVERY
2012 TO 2014
SHASUN CHEMICALS AND
PHARMACEUTICALS GENERICS 2014 TO PRESENT

2. EXPERIENCE:
8+ Years Experience in both process R@D and Medicinal chemistry R@D.
Worked as an FTE for Pfizer and synthesized more than 200 new cephalosporin molecules.
Worked as an active member in the development of a non-infringing process for the antibiotic
‘Cefotiam Dihydrochloride’
Worked as an active member in the development of a process for ‘Cefpirome Sulphate’ for US
market
Worked as an active member in the development of a non-infinging process for the antibiotic
‘Ceftazidime’
Worked as an active member in the development of yield improvement process for carbapenem
antibiotic ‘ Imipenem’
Worked as an active member in the development of a reagent for the enantiomer selectivity of
‘SAMe (S-adenosyl methionine)’, a neutraceutical
Worked as an active member in sorting out the problem of Reconstitution in the drug ‘Meropenem’
Worked as an active member in the development of ‘Ceftaroline Fosamil acetate’
Worked as an active member in the preparation of four major impurities(C,D,E,F) for ‘Naratriptan’
Worked as a member to optimize a cost effective route for the drug ‘Piperacillin’.
Presently working on the development of a process for the manufacture of ‘Sapropterin
dihydrochloride’
PROJECTS WORKED:
CEFTAZIDIME
CEFPIROME
CEFQUINOME
CEFOTIAM

3. IMIPENEM
MEROPENEM
CEFTAROLINE
NARATRIPTAN
NEW CEPHALOSPORIN MOLECULES
CEPHALOSPORIN DISCOVERY
PIPERACILLIN
SAPROPTERIN
PRESENT ASSIGNMENT:
Presently working with the Generics team at SSL to develop cost effective and non-infringing process
for the drug Sapropterin. The KSM for the drug was unavailable in the market, though available was not
commercially economical. Hence a process was developed much economical than the commercial sample.
REAGENTS HANDLED:
Sodium Hydride
n-Butyl lithium
BF3 Gas
Tributyl stannyl compounds
Mukaiyama reagent
Palladium reagent
Palladium on carbon (10%)
EDC-HOBT
Chlorinating reagents
Brominating reagents
Acid chlorides and Bromides.
Reducing agents metallic hydrides (LAH, SBH)
Oxidizing agents (PCC,PDC,TEMPO,SWERN,DESS MARTIN)

4. ANALYTICAL AND BIOLOGY KNOWLEDGE:
Structural Elucidation of chemical entities and process impurities by NMR, IR, Mass, GC-MS and HPLC analysis.
Structural Elucidation of the newly synthesized compounds via NMR, IR and MS.
Evaluation of the Biological screening data.
PRESENT CTC: 6 Lakhs per annum.
REFERENCES:
 Dr.U.P.SENTHILKUMAR,
Senior vice president,
Orchid chemicals and pharmaceuticals limited,
Sholinganallur,
Chennai, India – 600 119,
Contact No-9840720191.
 Dr.S.MOHAN,
Deputy General Manager,
Department of organic Synthesis,
Shasun chemicals and pharmaceuticals limited,
Keelakottaiyur,
Chennai, India – 600 127,
Contact No-9841184434.

5. PERSONAL PROFILE
Name : M.Iyappan
Date ofBirth : Dec 28th
1982
Sex : Male
Blood Group : A+ve
Religion : Hindu
Nationality : Indian
TO WHOMSOEVER IT MAY CONCERN
I stand guarantee to the authenticity of all the information furnished above.
Place: Chennai SIGNATURE
Date:
(IYAPPAN.M)