Interpretation By Wednesday, February 20, 2013, post your assignment to the M1: Assignment 3 Dropbox. Problem Situation: The CEO of your company has asked you, the human resource manager, to conduct a study to determine whether or not male managers and female managers perceive leadership styles differently and, if differences are found, to develop a training program that will benefit gender differences in leadership. To this end you selected, randomly, 10 male managers and 10 female managers to participate in your study. To each manager a leadership style survey questionnaire was administered. The questionnaire chosen was the Blake & Mouton Managerial Grid as it assesses leadership behavior. The numeric raw data results of the 18 question study are as follows: Raw Numeric Questionnaire Data Question 1 2 3 4 5 6 7 8 9 Male 4 4.6 3.2 3.9 4.2 3.7 4.1 4.5 3.5 Female 4.2 4.1 4.2 4.6 3.9 4.1 4.7 4.1 4.2 Raw Numeric Questionnaire Data Question 10 11 12 13 14 15 16 17 18 Male 4 3.9 4 3 4.5 4.9 3 3.3 3 Female 4 4.2 4.1 4 4.5 4.3 3.9 4 3.7 Complete the following in a single MS Word or Excel document: 1. Calculate the mean, median, mode, variance, and standard deviation for the numeric data. 2. Construct a histogram, pie, or Stem-Leaf Display chart encompassing the mean leadership scores for both male and female managers. Use an online interactive program to formulate your histogram, pie charts, or Stem-Leaf Display. 3. Construct a histogram for median score values for male managers and female managers with respect to management style. 4. Analyze the data and present preliminary conclusions based on answers to questions #2 and #3 with respect to the leadership style differences between male and female managers. 5. Offer a brief 5-point summary of the training program you might use to strengthen the leadership deficiencies found in either or both the male and female manager leadership style. Assignment 3 Grading Criteria Maximum Points Accurately calculated the mean, median, mode, variance, and standard deviation for the numeric data. 20 Constructed a histogram, pie, or Stem-Leaf Display chart encompassing the mean leadership scores for both male and female managers. 20 Constructed a histogram for median score values for male managers and female managers with respect to management style. 20 Offered a brief 5-point summary of the training program one might use to strengthen the leadership deficiencies found in either or both the male and female manager leadership style. 35 Presentation was free of grammatical and spelling errors. 5 Total: 100 Exercise 2 The activity of isocitrate dehydrogenase from kidney was assayed and the data obtained are presented in figure 1. Figure 1. Isocitrate dehydrogenase; variation of rate of reaction with isocitrate concentration. Questions (exercise 2): a) Compare the shapes of the curves for the rate of reaction against L-isocitrate concentration in the presence and abse.

1. Interpretation
By Wednesday, February 20, 2013, post your assignment to the
M1: Assignment 3 Dropbox.
Problem Situation:
The CEO of your company has asked you, the human resource
manager, to conduct a study to determine whether or not male
managers and female managers perceive leadership styles
differently and, if differences are found, to develop a training
program that will benefit gender differences in leadership. To
this end you selected, randomly, 10 male managers and 10
female managers to participate in your study. To each manager
a leadership style survey questionnaire was administered. The
questionnaire chosen was the Blake & Mouton Managerial
Grid as it assesses leadership behavior. The numeric raw data
results of the 18 question study are as follows:
Raw Numeric Questionnaire Data
Question
1
2
3
4
5
6
7
8
9
Male
4
4.6
3.2
3.9

2. 4.2
3.7
4.1
4.5
3.5
Female
4.2
4.1
4.2
4.6
3.9
4.1
4.7
4.1
4.2
Raw Numeric Questionnaire Data
Question
10
11
12
13
14
15
16
17
18
Male
4
3.9
4
3
4.5
4.9
3
3.3

3. 3
Female
4
4.2
4.1
4
4.5
4.3
3.9
4
3.7
Complete the following in a single MS Word or Excel
document:
1. Calculate the mean, median, mode, variance, and standard

4. deviation for the numeric data.
2. Construct a histogram, pie, or Stem-Leaf Display chart
encompassing the mean leadership scores for both male and
female managers. Use an online interactive program to
formulate your histogram, pie charts, or Stem-Leaf Display.
3. Construct a histogram for median score values for male
managers and female managers with respect to management
style.
4. Analyze the data and present preliminary conclusions based
on answers to questions #2 and #3 with respect to the leadership
style differences between male and female managers.
5. Offer a brief 5-point summary of the training program you
might use to strengthen the leadership deficiencies found in
either or both the male and female manager leadership style.
Assignment 3 Grading Criteria
Maximum Points
Accurately calculated the mean, median, mode, variance, and
standard deviation for the numeric data.
20
Constructed a histogram, pie, or Stem-Leaf Display chart
encompassing the mean leadership scores for both male and
female managers.
20
Constructed a histogram for median score values for male
managers and female managers with respect to management

5. style.
20
Offered a brief 5-point summary of the training program one
might use to strengthen the leadership deficiencies found in
either or both the male and female manager leadership style.
35
Presentation was free of grammatical and spelling errors.
5
Total:
100
Exercise 2
The activity of isocitrate dehydrogenase from kidney was
assayed and the data obtained are presented in figure 1.
Figure 1. Isocitrate dehydrogenase; variation of rate of reaction
with isocitrate concentration.
Questions (exercise 2):
a) Compare the shapes of the curves for the rate of reaction
against L-isocitrate concentration in the presence and absence
of ADP. Explain the effect of ADP and the underlying
mechanism.
(4 marks)

6. b) Explain the metabolic significance of the effect of ADP on
the activity of isocitrate dehydrogenase.
(2 marks)

7. c) Name any other intracellular molecules that normally
regulate the activity of this enzyme and state whether they are
activators or inhibitors and through which mechanism.
(2 marks)

8. Exercise 3
The data in the table below represents part of the laboratory
analysis for a five day old female child rushed into hospital
unconscious.
Table 2.Laboratory analysis.
Analyte
Patient Value
Reference Values
Blood
Leucine
2470 mol/L
40-158
Isoleucine
850 mol/L
13-81
Allo-Isoleucine
127 mol/L
<5
Valine
970 mol/L
85-334
Glutamate

9. 72 mol/L
11-79
Glutamine
806 mol/L
475-746
Phenylalanine
60 mol/L
34-101
alpha-ketoisocaproate
876 mol/L
24-44
Urine
Leucine
1559 mol/g creatinine
78-195
Isoleucine
463 mol/g creatinine
125-390
Valine
415 mol/g creatinine
113-369
alpha-ketoisocaproate
287 mol/g creatinine
<15
Questions (exercise 3):
d) What condition is the child suffering from? Explain your
‘diagnosis’ in terms of each of the data in the table.

10. (5 marks)
i) What is the underlying [biochemical] cause of the condition
the patient is suffering from? Include details of any relevant
enzymatic reactions/pathways.
(3 marks)

11. j) What ‘unusual’ metabolite, not listed above, would you also
expect to be found in the urine of the child? Explain how this
metabolite might be related to the diagnosed disorder.
(3 marks)

12. k) Once stabilised the child was maintained on dietary therapy.
Outline what form the dietary therapy would take, including any
‘supplements’ that may be added to the basic diet as required.
[please note the patients age]
(4 marks)

13. Exercise 4
Acetyl-CoA carboxylase is a key regulatory enzyme in fatty
acid synthesis. Early studies on the molecular properties of this
enzyme purified from avian liver produced the data given in
table 3.
Table 3. Molecular properties of avian acetyl-CoA carboxylase
Treatments
Sedimentation coefficient (S)
Molecular mass (kDa)
Catalytic activity (arbitrary units)
10 mM citrate
55-59
4000-8000
35
0.5M NaCl, pH8-9
13.1
410
2.5

14. l) Explain the results shown in table 3 in terms of the molecular
structure of acetyl-CoA carboxylase and comment on their
apparent physiological significance.
(4 marks)
m) Which cellular compartment would you expect the acetyl-
CoA carboxylase activity to have been observed in and why?
(2 marks)

15. 1