This document discusses a collaboration between UberCloud, HPE, and Intel to provide hybrid HPC and HPC as a service. It describes a case study called the Living Heart Project that used the hybrid HPC resources to run cardiac simulations using ANSYS. The project was able to run large simulations of up to 240 cores to study drug-induced arrhythmias in virtual human heart models. The simulations generated results like electrocardiograms that demonstrated the arrhythmic effects of different drugs.

1. Hybrid HPC and HPC as a Service
UberCloud, HPE and Intel collaboration
Case Study: Living Heart Project
Burak Yenier & Wolfgang Gentzsch
The UberCloud
Intel® HPC Developer Conference 2017
Denver, CO, November 11 – 12, 2017

2. 2012 2013 2014 2016
Start Cloud
Experiments
(200 so far)
2015
HPC Container
Development
CAE software
containers
Online
Marketplace
(45+ stores)
Intel - HPE - UberCloud Partnership 2012 - 2017
2017
Hybrid HPC
Living Heart
Project
Intel/UberCloud/LLNL
LLNL multi-container
multi-node project

3. Lessons Learned
What we learnt from 200 cloud experiments and 80 case studies
Security
PerformanceUsability
Software

4. Hybrid HPC Approach
Right-Sized
Infrastructure
1
End User in
Control
3
Enables New
Capabilities
4
Faster Time
to Solution
2

5. Example: UberCloud ANSYS Container

6. UberCloud ANSYS Container

7. Bare Metal Performance

8. HPE UberCloud Stack v0.0
Legacy HPC Private Cloud Public Cloud
Micro Focus Cloud Service Automation
Micro Focus Operations Orchestrator

9. What we learned from v0.0
• Proved that a bare-metal HPC as a Service solution works and is
production-ready for HPE customers
• The need for an automated HPC life cycle mgmt layer became clear
• Hybrid HPC customers prefer interchangeable components to make
integration with existing systems easier

10. Hybrid Cloud
Micro Focus Cloud Service Automation
Micro Focus Operations Orchestrator
HPE CMU HPC Automated Life Cycle
Management Layer
HPE UberCloud Stack v1.0

11. Hybrid HPC Workflow
• Service Signup
• Contact HPE and sign up for the Hybrid HPC service
• An HPE Partner creates administrator account for Cloud Service
Automation and define service levels, security parameters
• User and Offer Setup
• PointNext creates user accounts for Cloud Service Automation
• PointNext and UberCloud create the various HPC software offers
• Self-Service Hybrid HPC
• Users gain access to on-demand Hybrid HPC offers through Cloud
Service Automation and manage the life cycle.

12. HPE UberCloud Security Layers
HTTPS/VPN Access*
OS Firewall
OS PKI Login
Network & Storage
Segmentation
Dedicated Servers in
High Security Data
Centers
Single tenant, bare metal servers (not shared between customers). These
servers reside in professionally managed, highly secured data centers.
Network and Storage tiers are segmented automatically. Each customer
gets a private HPE CMU, a private IP range, and a private storage volume
Admin access is protected by Public Key Encryption (vs passwords, which
can be guessed)
Servers are protected with firewalls. Only necessary ports are turned on to
reduce attacks
Connection to our servers are protected by strong encryption techniques such
as HTTPS and VPN (HTTPS/VPN access and Disk Encryption are optional)

13. Case Study: The Living Heart Project
Studying Drug-induced Arrhythmias of a
Human Heart with Abaqus 2017 in the Cloud

14. The Living Heart Project
• Leading cardiovascular researchers, educators, medical
device developers, regulatory agencies, and practicing
cardiologists
• Shared mission to develop and validate highly accurate
personalized digital human heart models (DHHM).
• Models establish a unified foundation for cardiovascular
in silico medicine
• Models serve as a common technology base for
education and training, medical device design, testing,
clinical diagnosis and regulatory science
• Rapidly translating current and future cutting-edge
innovations directly into improved patient care.

15. HPCaaS Environment and Simulations
Advania / HPE / Intel / UberCloud
• Advania’s HPC as a Service (HPCaaS) hardware configuration
• Built upon HPE ProLiant servers XL230 Gen9
• Each with 2x Intel Broadwell E5-2683 v4 with Intel OmniPath
interconnect
• UberCloud HPC software containers hosting Stanford’s
workflow
• Dassault SIMULIA Abaqus for fluid-structure interaction and
advanced electro-physiological modelling

16. HPCaaS Environment and Simulations
Advania / HPE / Intel / UberCloud
• LHP model scaled well up to 240 compute cores
• 42 simulations each 40 hours on 5-node (160-core) subsystem
• Study: drugs causing arrhythmias or not; applying drugs by
blocking different ionic currents in our cellular model, replicating
what has been observed before in cellular experiments
• For each case, we let the heart beat naturally and see if the
arrhythmia is developing
Goal: create a biventricular finite element model to study drug-induced
arrhythmias of a human heart.

17. Simulation Results
Evolution of electrical activity: After application of Quinidine, the electrical propagation
turns chaotic, showing the high risk of Quinidine to produce arrhythmias.

18. Simulation Results
Electrocardiogram (ECG) without and with the drug Sotalol
ECG tracing for healthy, baseline case
Arrhythmic development after
applying the drug Sotalol. The ECG
demonstrates that the arrhythmia is
of Torsades de Pointes type.
Note: These are simulation results !

19. Healthy case versus drug-induced case
Application of the drug Quinidine where we observe Torsades de Points arrhythmia

20. Take Aways
• UberCloud is part of the HPE’s HPCaaS
offering “Hybrid HPC”
• UberCloud Containers give us a way to
solve software management problems
without performance issues
• Able to manage and run the most complex
engineering workflows
• Providing SaaS-like user experience and
desktop level ease of use