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Helping Patients Regulate Their INR
       Helping Warfarin Patients Better
             www.INRTracker.com
              Manage Their INR
Veronica Coulombe                                      Pavan Katepalli
                       Presented by: Veronica Coulombe & Pavan Katepalli
Co-founder & CEO                                       Co-founder & CTO
              Veronica.Coulombe@inrtracker.com | Pavan.Katepalli@inrtracker.com
Veronica.Coulombe@inrtracker.com                       Pavan.Katepalli@inrtracker.com
                       © Copyright 2013, INR Tracker, www.INRTracker.com
                                                          © Copyright 2013 | www.INRTracker.com
Mission
 In 2004 and 2005, Warfarin was implicated in an annual average of 43,000 ER
 visits for adverse drug events (ADE’s).

 That’s second only to ADE’s involving insulin, and it doesn’t include Warfarin-
   Helping Patients Regulate Their INR
 related ADE’s in hospitals, nursing homes, clinics, offices, or homes.*1+



                www.INRTracker.com the
         INR Tracker provides patients with
  necessary tools and support to better manage
            their Warfarin treatment
Veronica Coulombe                              Pavan Katepalli
Co-founder & CEO                               Co-founder & CTO
Veronica.Coulombe@inrtracker.com               Pavan.Katepalli@inrtracker.com
                                                 © Copyright 2013 | www.INRTracker.com
Problem
 An INR test measures the clotting time of a patient’s blood. Warfarin, a blood
 thinner used by over 2 million people in the US, requires several INR tests
 each month.

    Helping Patients Regulate Their INR
 Frequent testing is obligatory for Warfarin patients, because Warfarin
 interacts with a variety of things:
      – Food
                    www.INRTracker.com
      – Prescription medicines
      – Over-the-counter medicines
      – Exercise
      – Weather
      – Menstruation
Veronica Coulombe                              Pavan Katepalli
      – And more…
Co-founder & CEO                               Co-founder & CTO
Veronica.Coulombe@inrtracker.com              Pavan.Katepalli@inrtracker.com
                                                © Copyright 2013 | www.INRTracker.com
Problem
 Warfarin interactions can cause the drug to be more potent, which will
 increase the clotting time, or less potent, which will decrease the clotting
 time. Any change in the clotting time of blood that is outside the therapeutic
 range will usually result in a drug dosage adjustment.
   Helping Patients Regulateconsequences such as
 Not having the appropriate drug dosage can have fatal
                                                       Their INR
 severe bleeding and blood clots.

                     www.INRTracker.com
 The burden of frequent INR tests can result in:
     – Increased medical costs
     – Reduced quality of life (e.g. lifestyle restrictions and increased
        bleeding risk)
     – Patient dissatisfaction (e.g. inconsistent INR’s)
Veronica Coulombe                                Pavan Katepalli
     – Discontinuation of therapy [2]
Co-founder & CEO                                 Co-founder & CTO
Veronica.Coulombe@inrtracker.com                Pavan.Katepalli@inrtracker.com
                                                 © Copyright 2013 | www.INRTracker.com
Solution
 INR Tracker provides the necessary online tools for Warfarin patients to
 monitor their at home activity and better manage Warfarin interactions.

 Our current online tools allow patients
    Helping Patients Regulate Their INR
 to record their:
      –   INR readings
      –   Doctor appointments
      –
      –
                         www.INRTracker.com
          Drug dosages, missed dosages, extra dosages
          Exercise
      –   Weight
      –   Additional custom notes
      –   The Vitamin K in 7,906 foods from the USDA’s
          food database
      –   Alcohol intake
Veronica Coulombe                            Pavan Katepalli
 We built a minimum viability product to testCo-founder & CTO
Co-founder & CEO                              and de-risk our assumptions.
Veronica.Coulombe@inrtracker.com             Pavan.Katepalli@inrtracker.com
                                                         © Copyright 2013 | www.INRTracker.com
Target Market
 Warfarin is the most commonly prescribed anticoagulant medicine on the
 market. [3]
 Roughly 2 million people take Warfarin each year in the United States. It is
    Helping Patients Regulate Their INR
 prescribed to patients who are at risk of developing blood clots. These
 conditions include:
     – Atrial fibrillation (a type of abnormal heart beat)
                    www.INRTracker.com
     – Recurrent strokes
     – Deep venous thrombosis
     – Pulmonary embolism
     – Heart valve replacement recipient [4]
Veronica Coulombe                            Pavan Katepalli
Co-founder & CEO                             Co-founder & CTO
Veronica.Coulombe@inrtracker.com             Pavan.Katepalli@inrtracker.com
                                                © Copyright 2013 | www.INRTracker.com
User Acquisition
                          Signups Per Month
 120

 100
   Helping Patients Regulate Their INR
  80

  60
                  www.INRTracker.com
  40

  20

   0
Veronica Coulombe                       Pavan Katepalli
        1-Apr 1-May 1-Jun 1-Jul 1-Aug 1-Sep 1-Oct 1-Nov 1-Dec 1-Jan
Co-founder & CEO                        Co-founder & CTO
Veronica.Coulombe@inrtracker.com        Pavan.Katepalli@inrtracker.com
                                          © Copyright 2013 | www.INRTracker.com
User Acquisition
                        Unique Hits Per Month
 4500
 4000
   Helping Patients Regulate Their INR
 3500
 3000
 2500
 2000             www.INRTracker.com
 1500
 1000
  500
    0
Veronica Coulombe                        Pavan Katepalli
         1-Apr 1-May 1-Jun 1-Jul 1-Aug 1-Sep 1-Oct & CTO 1-Dec 1-Jan
Co-founder & CEO                         Co-founder 1-Nov
Veronica.Coulombe@inrtracker.com         Pavan.Katepalli@inrtracker.com
                                           © Copyright 2013 | www.INRTracker.com
User Acquisition
             Conversion % = (sign ups/unique hits) * 100% Per Month
 10.00%
  9.00%

   Helping Patients Regulate Their INR
  8.00%
  7.00%
  6.00%
  5.00%
  4.00%            www.INRTracker.com
  3.00%
  2.00%
  1.00%
  0.00%
Veronica Coulombe                        Pavan Katepalli
Co-founder1-Apr 1-May 1-Jun 1-Jul 1-Aug 1-Sep 1-Oct & CTO 1-Dec 1-Jan
           & CEO                         Co-founder 1-Nov
Veronica.Coulombe@inrtracker.com         Pavan.Katepalli@inrtracker.com
                                               © Copyright 2013 | www.INRTracker.com
Competition
                                  3quibits   Vitamin K Tracker   Dr Gourmet    INR Tracker
Online Tools                                                                     
Apps                                                                            soon
Record INR history                                                               
Record Doctors Appointments                                                      
      Helping Patients Regulate Their INR
Record Drug Dosages
Record Missed Dosages
                                     
                                     
                                                    
                                                    
                                                                 
                                                                 
                                                                                    
                                                                                    
Record Extra Dosages                                                             
Record Weight                                                                    
Record Exercise                                                                  
Record Weather
Custom Reports
                             www.INRTracker.com
                                     
                                     
                                                    
                                                    
                                                                 
                                                                 
                                                                                   soon
                                                                                    
Email Reminders                                                                 soon
Track Vitamin K in Single Foods                                                  
Track Vitamin C in Single Foods                                                  
Track Vitamin E in Single Foods                                                  
Create Custom Meals                                                             soon
Find PremadeCoulombe
Veronica Recipes                                    Pavan Katepalli
                                                                                  soon
Allows Social Communication                                                     soon
Co-founder & CEO                                      Co-founder & CTO
Veronica.Coulombe@inrtracker.com                      Pavan.Katepalli@inrtracker.com
                                                        © Copyright 2013 | www.INRTracker.com
Future Product Features
 Website                             Mobile & Social
 • Responsive website redesign       • Smartphone application that will:
     (demo)                              – Log food using an image snapshot
   Helping Patients Regulate Their INR
 • Premium paid membership               – Query the food database
                                         – Account management ability
 • Better reporting & nutrient
     tracking                        • Social Network consisting of
                   www.INRTracker.com
 • Text message alerts
                                       support groups and user
                                       submitted meals
 • Email reminders
                                     • Better doctor-to-patient
 • Ability to create custom meals      communication, articles written
     and find pre made meals           by doctors & nutritionists
 • Dynamic diet plans (what to eat
Veronica Coulombe                        Pavan Katepalli
Co-founder & CEO it)
     and when to eat                     Co-founder & CTO
Veronica.Coulombe@inrtracker.com         Pavan.Katepalli@inrtracker.com
                                          © Copyright 2013 | www.INRTracker.com
Team

              Veronica Coulombe | Co-Founder & CEO
                 Front-End Developer
   Helping Patients Regulate Their INR
                 Learn more about me: Linked In



                  www.INRTracker.com
              Pavan Katepalli | Co-Founder & CTO
                 Engineer
                 Learn more about me: Linked In | Blog

Veronica Coulombe                          Pavan Katepalli
Co-founder & CEO                           Co-founder & CTO
Veronica.Coulombe@inrtracker.com           Pavan.Katepalli@inrtracker.com
                                            © Copyright 2013 | www.INRTracker.com
Financials
We take pride in being a lean startup. Total startup costs of INR
Tracker:

   Helping Patients Date
     Expense        Regulate Their INR
                                Cost
Domain name                   3/22/2012                           $10
Hosting                     already existed                       $0
PHP scripts
                 www.INRTracker.com
                       3/25/2012                                  $65
SEO software                already existed                       $0


 Total
Veronica Coulombe                         Pavan Katepalli   $75
Co-founder & CEO                          Co-founder & CTO
Veronica.Coulombe@inrtracker.com          Pavan.Katepalli@inrtracker.com
                                              © Copyright 2013 | www.INRTracker.com
Thank You
 Thank you for taking the time to view this presentation!

 Please contact us if you have any questions.
   Helping Patients Regulate Their INR
    Veronica Coulombe, CEO
     Veronica.Coulombe@gmail.com

                    www.INRTracker.com
     Pavan Katepalli, CTO
     PavanKat@gmail.com




Veronica Coulombe                               Pavan Katepalli
Co-founder & CEO                                Co-founder & CTO
Veronica.Coulombe@inrtracker.com                Pavan.Katepalli@inrtracker.com
                                                 © Copyright 2013 | www.INRTracker.com
Citations
 1.    Carlson, Bob. BioCommunications LLC, "Declaring War on Warfarin Misdosing." Last modified Jul-
       Aug, 2008. Accessed April 24, 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706162/.

 2.    University of Pennsylvania School of Medicine , "Genotyped Guided Dosing of Warfarin Clinical Trial
       Funding Opportunity - Central Laboratory RFP." Last modified July 16, 2008. Accessed April 24, 2012.
       http://rt5.cceb.med.upenn.edu/warfdcc/WARF-1_pg5.html.

 3.   Helping Patients Regulate Their INR
       IMS Institute for Healthcare Informatics, "The Use of Medicines in the United States: Review of
       2011, Top Medicines by Prescriptions." Last modified February 17, 2012. Accessed April 24, 2012.
       http://www.imshealth.com/ims/Global/Content/Insights/IMS Institute for Healthcare
       Informatics/IHII_Medicines_in_U.S_Report_2011.pdf.

 4.                        www.INRTracker.com
       University of Wisconsin, Madison, "Pharmaceuticals in Historical Context, Warfarin: A Chapter in
       International Standardization of Therapeutic Practices beyond a Commercialized Drug." Last modified
       October 22-23, 2010. Accessed April 24, 2012.
       http://www.pharmacy.wisc.edu/sites/default/files/private/american-institute-history-
       pharmacy/AIHPconf2010.pdf.


Veronica Coulombe                                               Pavan Katepalli
Co-founder & CEO                                                Co-founder & CTO
Veronica.Coulombe@inrtracker.com                                Pavan.Katepalli@inrtracker.com
                                                                  © Copyright 2013 | www.INRTracker.com

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INRtracker.com Deck

  • 1. Helping Patients Regulate Their INR Helping Warfarin Patients Better www.INRTracker.com Manage Their INR Veronica Coulombe Pavan Katepalli Presented by: Veronica Coulombe & Pavan Katepalli Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com | Pavan.Katepalli@inrtracker.com Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013, INR Tracker, www.INRTracker.com © Copyright 2013 | www.INRTracker.com
  • 2. Mission In 2004 and 2005, Warfarin was implicated in an annual average of 43,000 ER visits for adverse drug events (ADE’s). That’s second only to ADE’s involving insulin, and it doesn’t include Warfarin- Helping Patients Regulate Their INR related ADE’s in hospitals, nursing homes, clinics, offices, or homes.*1+ www.INRTracker.com the INR Tracker provides patients with necessary tools and support to better manage their Warfarin treatment Veronica Coulombe Pavan Katepalli Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 3. Problem An INR test measures the clotting time of a patient’s blood. Warfarin, a blood thinner used by over 2 million people in the US, requires several INR tests each month. Helping Patients Regulate Their INR Frequent testing is obligatory for Warfarin patients, because Warfarin interacts with a variety of things: – Food www.INRTracker.com – Prescription medicines – Over-the-counter medicines – Exercise – Weather – Menstruation Veronica Coulombe Pavan Katepalli – And more… Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 4. Problem Warfarin interactions can cause the drug to be more potent, which will increase the clotting time, or less potent, which will decrease the clotting time. Any change in the clotting time of blood that is outside the therapeutic range will usually result in a drug dosage adjustment. Helping Patients Regulateconsequences such as Not having the appropriate drug dosage can have fatal Their INR severe bleeding and blood clots. www.INRTracker.com The burden of frequent INR tests can result in: – Increased medical costs – Reduced quality of life (e.g. lifestyle restrictions and increased bleeding risk) – Patient dissatisfaction (e.g. inconsistent INR’s) Veronica Coulombe Pavan Katepalli – Discontinuation of therapy [2] Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 5. Solution INR Tracker provides the necessary online tools for Warfarin patients to monitor their at home activity and better manage Warfarin interactions. Our current online tools allow patients Helping Patients Regulate Their INR to record their: – INR readings – Doctor appointments – – www.INRTracker.com Drug dosages, missed dosages, extra dosages Exercise – Weight – Additional custom notes – The Vitamin K in 7,906 foods from the USDA’s food database – Alcohol intake Veronica Coulombe Pavan Katepalli We built a minimum viability product to testCo-founder & CTO Co-founder & CEO and de-risk our assumptions. Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 6. Target Market Warfarin is the most commonly prescribed anticoagulant medicine on the market. [3] Roughly 2 million people take Warfarin each year in the United States. It is Helping Patients Regulate Their INR prescribed to patients who are at risk of developing blood clots. These conditions include: – Atrial fibrillation (a type of abnormal heart beat) www.INRTracker.com – Recurrent strokes – Deep venous thrombosis – Pulmonary embolism – Heart valve replacement recipient [4] Veronica Coulombe Pavan Katepalli Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 7. User Acquisition Signups Per Month 120 100 Helping Patients Regulate Their INR 80 60 www.INRTracker.com 40 20 0 Veronica Coulombe Pavan Katepalli 1-Apr 1-May 1-Jun 1-Jul 1-Aug 1-Sep 1-Oct 1-Nov 1-Dec 1-Jan Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 8. User Acquisition Unique Hits Per Month 4500 4000 Helping Patients Regulate Their INR 3500 3000 2500 2000 www.INRTracker.com 1500 1000 500 0 Veronica Coulombe Pavan Katepalli 1-Apr 1-May 1-Jun 1-Jul 1-Aug 1-Sep 1-Oct & CTO 1-Dec 1-Jan Co-founder & CEO Co-founder 1-Nov Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 9. User Acquisition Conversion % = (sign ups/unique hits) * 100% Per Month 10.00% 9.00% Helping Patients Regulate Their INR 8.00% 7.00% 6.00% 5.00% 4.00% www.INRTracker.com 3.00% 2.00% 1.00% 0.00% Veronica Coulombe Pavan Katepalli Co-founder1-Apr 1-May 1-Jun 1-Jul 1-Aug 1-Sep 1-Oct & CTO 1-Dec 1-Jan & CEO Co-founder 1-Nov Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 10. Competition 3quibits Vitamin K Tracker Dr Gourmet INR Tracker Online Tools     Apps    soon Record INR history     Record Doctors Appointments     Helping Patients Regulate Their INR Record Drug Dosages Record Missed Dosages         Record Extra Dosages     Record Weight     Record Exercise     Record Weather Custom Reports www.INRTracker.com       soon  Email Reminders    soon Track Vitamin K in Single Foods     Track Vitamin C in Single Foods     Track Vitamin E in Single Foods     Create Custom Meals    soon Find PremadeCoulombe Veronica Recipes   Pavan Katepalli  soon Allows Social Communication    soon Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 11. Future Product Features Website Mobile & Social • Responsive website redesign • Smartphone application that will: (demo) – Log food using an image snapshot Helping Patients Regulate Their INR • Premium paid membership – Query the food database – Account management ability • Better reporting & nutrient tracking • Social Network consisting of www.INRTracker.com • Text message alerts support groups and user submitted meals • Email reminders • Better doctor-to-patient • Ability to create custom meals communication, articles written and find pre made meals by doctors & nutritionists • Dynamic diet plans (what to eat Veronica Coulombe Pavan Katepalli Co-founder & CEO it) and when to eat Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 12. Team Veronica Coulombe | Co-Founder & CEO Front-End Developer Helping Patients Regulate Their INR Learn more about me: Linked In www.INRTracker.com Pavan Katepalli | Co-Founder & CTO Engineer Learn more about me: Linked In | Blog Veronica Coulombe Pavan Katepalli Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 13. Financials We take pride in being a lean startup. Total startup costs of INR Tracker: Helping Patients Date Expense Regulate Their INR Cost Domain name 3/22/2012 $10 Hosting already existed $0 PHP scripts www.INRTracker.com 3/25/2012 $65 SEO software already existed $0 Total Veronica Coulombe Pavan Katepalli $75 Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 14. Thank You Thank you for taking the time to view this presentation! Please contact us if you have any questions. Helping Patients Regulate Their INR Veronica Coulombe, CEO Veronica.Coulombe@gmail.com www.INRTracker.com Pavan Katepalli, CTO PavanKat@gmail.com Veronica Coulombe Pavan Katepalli Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com
  • 15. Citations 1. Carlson, Bob. BioCommunications LLC, "Declaring War on Warfarin Misdosing." Last modified Jul- Aug, 2008. Accessed April 24, 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706162/. 2. University of Pennsylvania School of Medicine , "Genotyped Guided Dosing of Warfarin Clinical Trial Funding Opportunity - Central Laboratory RFP." Last modified July 16, 2008. Accessed April 24, 2012. http://rt5.cceb.med.upenn.edu/warfdcc/WARF-1_pg5.html. 3. Helping Patients Regulate Their INR IMS Institute for Healthcare Informatics, "The Use of Medicines in the United States: Review of 2011, Top Medicines by Prescriptions." Last modified February 17, 2012. Accessed April 24, 2012. http://www.imshealth.com/ims/Global/Content/Insights/IMS Institute for Healthcare Informatics/IHII_Medicines_in_U.S_Report_2011.pdf. 4. www.INRTracker.com University of Wisconsin, Madison, "Pharmaceuticals in Historical Context, Warfarin: A Chapter in International Standardization of Therapeutic Practices beyond a Commercialized Drug." Last modified October 22-23, 2010. Accessed April 24, 2012. http://www.pharmacy.wisc.edu/sites/default/files/private/american-institute-history- pharmacy/AIHPconf2010.pdf. Veronica Coulombe Pavan Katepalli Co-founder & CEO Co-founder & CTO Veronica.Coulombe@inrtracker.com Pavan.Katepalli@inrtracker.com © Copyright 2013 | www.INRTracker.com