Stanford Engineering Professor Ingmar Riedel-Kruse describes how he's creating biotic games in which humans play with real biological processes at microscopic scale. The goal is to enable crowd-sourcing of the scientific method to yield real-world advances in biotechnology.
Today most people on Earth are connected through wired or wireless networks, or both. The next leap in connectivity will give people the ability to control objects and machines. The Internet of Everything (IoE) will tag objects with tiny wireless devices for communication, computation and sensing. Some projections show demand for such IoE smart sensors will grow from billions to trillions within a decade. The essential enabling technology is an ultra-low power smart radio to provide a unique IP address and location. In this talk, Amin Arbabian discusses how he developed an ant-sized wireless-powered radio chip that costs pennies to fabricate– making it cheap enough to become the missing link to enable the Internet of Everything.
Embedded computing is everywhere. It is in our car engines, refrigerators, and even in the singing greeting cards we send. With improvements in wireless technology, these systems are starting to talk with each other, and they are appearing in places like our shoes and wrists to monitor our athletic activity or health. This emerging Internet of Everything (IoE) has tremendous potential to improve our lives. But like any powerful technology, it also has a dark side: it will observe and implement many of our actions. Security in the IoE is likely to be even more critical than general Internet security. After reviewing some of the challenges in creating a secure IoE, Horowitz will describe a new research program at Stanford to address this issue.
Wireless has evolved from Marconi's station-to-station telegraphy, to audio and video broadcasting, to today’s person-to-person mobile digital communications. Each transition has surprised even the revolutionaries who brought it about, and each transformed civilization. We expect similar disruptions from the next phase of interconnectivity, in which a trillion objects join the conversation. Tech pundits have long talked about an Internet of Things, a vision most often dominated by machine-to-machine communications in industrial settings. Lee will make the case for the Internet of Everything in which humans will be involved in the most compelling applications yet to emerge. He will describe some possible futures, and how Stanford engineers are working to overcome significant challenges to realize those futures.
Professor Iaccarino provides a window into intriguing physical phenomena, the challenges of extreme-scale computations and simulations illustrating the fascinating beauty of fluid turbulence.
Today most people on Earth are connected through wired or wireless networks, or both. The next leap in connectivity will give people the ability to control objects and machines. The Internet of Everything (IoE) will tag objects with tiny wireless devices for communication, computation and sensing. Some projections show demand for such IoE smart sensors will grow from billions to trillions within a decade. The essential enabling technology is an ultra-low power smart radio to provide a unique IP address and location. In this talk, Amin Arbabian discusses how he developed an ant-sized wireless-powered radio chip that costs pennies to fabricate– making it cheap enough to become the missing link to enable the Internet of Everything.
Embedded computing is everywhere. It is in our car engines, refrigerators, and even in the singing greeting cards we send. With improvements in wireless technology, these systems are starting to talk with each other, and they are appearing in places like our shoes and wrists to monitor our athletic activity or health. This emerging Internet of Everything (IoE) has tremendous potential to improve our lives. But like any powerful technology, it also has a dark side: it will observe and implement many of our actions. Security in the IoE is likely to be even more critical than general Internet security. After reviewing some of the challenges in creating a secure IoE, Horowitz will describe a new research program at Stanford to address this issue.
Wireless has evolved from Marconi's station-to-station telegraphy, to audio and video broadcasting, to today’s person-to-person mobile digital communications. Each transition has surprised even the revolutionaries who brought it about, and each transformed civilization. We expect similar disruptions from the next phase of interconnectivity, in which a trillion objects join the conversation. Tech pundits have long talked about an Internet of Things, a vision most often dominated by machine-to-machine communications in industrial settings. Lee will make the case for the Internet of Everything in which humans will be involved in the most compelling applications yet to emerge. He will describe some possible futures, and how Stanford engineers are working to overcome significant challenges to realize those futures.
Professor Iaccarino provides a window into intriguing physical phenomena, the challenges of extreme-scale computations and simulations illustrating the fascinating beauty of fluid turbulence.
Professor Dionne explores the unique and enabling properties of nano-sized materials, with applications ranging from highly efficient solar-renewable technologies to optical computers and cloaks of invisibility.
Stanford Engineering Professor Olav Solgaard describes how optical fibers can be used to provide a crisp, three-dimensional window into human anatomy at a cellular level.
Engineers are leading the push to create greener products that will help us meet current and future sustainability challenges. Stanford Engineering Professor Mike Lepech discusses the impact of green engineering on our planet and on our daily lives.
Stanford Engineering Professor Monica Lam discusses her lab's work in developing an open social network aimed at giving users better control of their data and greater privacy.
Online communities are powerful but often out of reach to the poor and geographically isolated for technical and literacy reasons. Mobile phones can address both of these gaps. Stanford Engineering Professor Scott Klemmer and colleagues have pioneered voice-based social media tools to help rural communities connect online.
Stanford Engineering Professor Christina Smolke explains how advances in synthetic biology are revolutionizing medical treatment, prevention and diagnosis of disease. She made this presentation at the school's annual eDay (Engineering Day) event.
Judy Estrin, CEO of JLabs LLC and a serial entrepreneur discusses why innovation is so important and what it takes to be an entrepreneur. Estrin was involved in the development of TCP/IP and is a former Cisco CTO. A Stanford Engineering alum, she spoke at the school's annual eDay event.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Delivering Micro-Credentials in Technical and Vocational Education and TrainingAG2 Design
Explore how micro-credentials are transforming Technical and Vocational Education and Training (TVET) with this comprehensive slide deck. Discover what micro-credentials are, their importance in TVET, the advantages they offer, and the insights from industry experts. Additionally, learn about the top software applications available for creating and managing micro-credentials. This presentation also includes valuable resources and a discussion on the future of these specialised certifications.
For more detailed information on delivering micro-credentials in TVET, visit this https://tvettrainer.com/delivering-micro-credentials-in-tvet/
Professor Dionne explores the unique and enabling properties of nano-sized materials, with applications ranging from highly efficient solar-renewable technologies to optical computers and cloaks of invisibility.
Stanford Engineering Professor Olav Solgaard describes how optical fibers can be used to provide a crisp, three-dimensional window into human anatomy at a cellular level.
Engineers are leading the push to create greener products that will help us meet current and future sustainability challenges. Stanford Engineering Professor Mike Lepech discusses the impact of green engineering on our planet and on our daily lives.
Stanford Engineering Professor Monica Lam discusses her lab's work in developing an open social network aimed at giving users better control of their data and greater privacy.
Online communities are powerful but often out of reach to the poor and geographically isolated for technical and literacy reasons. Mobile phones can address both of these gaps. Stanford Engineering Professor Scott Klemmer and colleagues have pioneered voice-based social media tools to help rural communities connect online.
Stanford Engineering Professor Christina Smolke explains how advances in synthetic biology are revolutionizing medical treatment, prevention and diagnosis of disease. She made this presentation at the school's annual eDay (Engineering Day) event.
Judy Estrin, CEO of JLabs LLC and a serial entrepreneur discusses why innovation is so important and what it takes to be an entrepreneur. Estrin was involved in the development of TCP/IP and is a former Cisco CTO. A Stanford Engineering alum, she spoke at the school's annual eDay event.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Delivering Micro-Credentials in Technical and Vocational Education and TrainingAG2 Design
Explore how micro-credentials are transforming Technical and Vocational Education and Training (TVET) with this comprehensive slide deck. Discover what micro-credentials are, their importance in TVET, the advantages they offer, and the insights from industry experts. Additionally, learn about the top software applications available for creating and managing micro-credentials. This presentation also includes valuable resources and a discussion on the future of these specialised certifications.
For more detailed information on delivering micro-credentials in TVET, visit this https://tvettrainer.com/delivering-micro-credentials-in-tvet/
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
Thinking of getting a dog? Be aware that breeds like Pit Bulls, Rottweilers, and German Shepherds can be loyal and dangerous. Proper training and socialization are crucial to preventing aggressive behaviors. Ensure safety by understanding their needs and always supervising interactions. Stay safe, and enjoy your furry friends!
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
1. Biotic Games
Interactive micro-biology for
Research,
Education,
and
Entertainment
Ingmar Riedel-Kruse
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
2. Engineering and games
?
2
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
3. Questions
1. Can we bioengineer games?
2. What are these games like?
3. What are these games good for?
3
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
4. Games
4
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
8. What is bioengineering?
• Biology as an engineering substrate
• Fusion of engineering and the life sciences
• Technology invention
• Scientific discovery
• Applications in medicine, food, energy, environment …
8
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
10. Stanford bioengineering
Human Biomechanics Optogenetics
Scott Delp RNA logic gates
Christina Smolke Karl Deisseroth
Micro-fluidics – Steve Quake; Bubble logic - Manu Prakash ~500 um
10
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
12. Bioengineered games
12
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
13. Bioengineered games
(i) Human interaction with biological material or processes
(ii) Enabled by modern biotechnology
13
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
14. “Biotic games”
(i) Human interaction with biological material or processes
(ii) Enabled by modern biotechnology
14
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
15. Paramecia and random walks
3 2
4 1
9
50 um
8
5
0.5 mm
7 6
0.5 sec
15
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
16. Action games with paramecia
16
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
17. Biotic game set-up
Biotic processor
Fluid chamber Game controller
17
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
19. Pinball vs. “Biotic Pinball”
1 mm / real time
19
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
20. First publication on biotic games
20
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
21. Comments on the web
• useless.invention.ever
• Incredible!
• Are paramecia hurt? Unethical to play with life!
• It is more benign than picking a flower
• Cure cancer first!
• If they had Playstation in WW2, that is what the controller probably would look like.
• I really like Stanford having such multidisciplinary research opportunities.
21
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
22. Utility of future biotic games
1. Education
2. Large scale citizen science
3. Technology driver
4. …
22
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
23. Biotic games in education
23
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
24. First test with children in museum
Daniel Schwartz
Prof. School of Education, Stanford
Computer games for
education
24
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
25. First children test in museum
• ~40 children ~10 years old
• enjoyed direct visual through scope
• biotic game was too difficult to play
• hardly realized that they played with real paramecia
• no ethical concerns raised
-> different perceptions by age
-> implications for improved design
25
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
26. Games for research
26
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
27. Biotic games for large scale science
(citizen science / crowdsourcing / human computation)
Biomedical Experiments Operated by Online Gaming Community
27
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
28. Citizen science game: Beans
How many beans are in the jar?
Rules:
• Don’t talk
• Write down your guess
• Write down your name (other ID)
• Best guess wins
• Exchange guess with a stranger
• Let’s vote!
28
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
29. Biotic games for large scale science
Rhiju Das Adrien Trieulle
Assist. Prof. Computer Science /
Assist. Prof. Biochemistry, Stanford
Robotics; Carnegie Mellon
RNA folding
~10.000 players Computer graphics
Experimental feedback
Once per week for 8 players
29
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
30. RNA and folding
G U G G G A A A A A A C C C A C
Folding Sequence
problem problem
A A
C A C C C
A
G U G G G A
A A
40. Games as technological driver
40
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
41. Games as technological driver
(development of new technology and/or cost reductions)
3D video game graphics Graphics Processing Unit (GPU) Molecular dynamic simulations
Jen-Hsun Huang "Jen-Hsun Huang School of
(EE MS ’92 Stanford) Engineering Center."
41
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
42. Games as technological driver
(development of new technology and/or cost reductions)
Without video games
3D video game graphics Graphics Processing Unit (GPU) Molecular dynamic simulations
No deans office
Jen-Hsun Huang "Jen-Hsun Huang School of
(EE MS ’92 Stanford) Engineering Center."
42
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
43. Games as technological driver
(development of new technology and/or cost reductions)
3rd world mobile phone Integrating micro-fluidic
based diagnostics chips into phones?
Hongying Zhu et al. LOC 2010
Could biotic games lower costs for mobile diagnostics?
43
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
44. Outlook
44
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
45. Electrical vs. biological engineering
Transistor Electronic circuit “Tennis for two” Table Tennis
1958 2006; Xbox 360
1947 ~1950’s
???
Micro-fluidic valve Micro-fluidic circuit Biotic games
~2000 ~2002 ~2010
45
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu
46. Stanford Bio.X games initiative!
(Founded ~Spring 2010; Bio-X IIP seed-funding ~Fall 2010)!
Biotic Games Educational
video games
Rhiju Das Ingmar Riedel-Kruse Daniel Schwartz
(Asst Prof Biochemistry, Physics) (Asst Prof Bioengineering) (Prof Education)
Objectives:
1. Develop and build biotic games
2. Use biotic games to solve educational and scientific challenges
3. Nucleate a world-wide biotic games community
47. Summary Biotic Games
• Human player interacting with
real biology (experiments)
• Novel features
• Educational value
• Citizen science
• Technology driver
• …
• Stanford Bio.X games center
47
STANFORD BIOENGINEERING Riedel-Kruse Lab ingmar@stanford.edu