Inflammation is a process by which your body's white blood cells and the things they make protect you from infection from outside invaders, such as bacteria and viruses.

1. PRESENTED BY ,
Spurthi BS
Doctor of Pharmacy (PharmD)
Mallige college of pharmacy

7. CELSUS in 1st century A.D named the famous 4 cardinal signs
of inflammation as:
rubor (redness)
tumor (swelling)
calor (heat)
dolor (pain)
To these, 5th sign functio laesa, or loss of function was later
added by VIRCHOW
SIGNS OF INFLAMMATION

8. TYPESOFINFLAMMATION
ACUTE
Rapid onset
Short duration
Fluid accumulation, plasma protein exudation
Neutrophils
CHRONIC
Onset- insidious
Longer duration
Lymphocytes, macrophages, plasma cells as inflammatory
cells

23. ADHESION MOLECULES:
SELECTINS :
E-selectin
P-selectin
(cytokine-activated Endothelial cells)
(Preformed and stored in endothelial cells)
L-selectin (expressed on surface of Lymphocytes and
neutrophils)
INTEGRINS:
Activated during the process of loose and transient adhesions
between the endothelial cells and leucocytes.
IMMUNOGLOBULIN SUPER FAMILYADHESION
MOLECULE: ICAM-1,2

35. CHEMICAL MEDIATORS OF
INFLAMMATION
Also called as PERMEABILITY factors or ENDOGENOUS
factors.
The substances acting as chemical mediators of inflammation
may be released from the cells, the plasma, or damaged tissue
itself.
Classified into 2groups:
Mediators released by CELLS
Mediators originating from PLASMA

39. CHRONIC INFLAMMATION

46. MACROPHAGE ACTIVATION