7 sem ppt practice school.

1. DR R N LAHOTI INSTITUTE OF
PHARMACEUTICALS EDUCATION AND
RESEARCH CENTRE
Practice school report
submitted to
DR R N LAHOTI INSTITUTE OF PHARMACEUTICALS EDUCATION AND RESEARCH
CENTRE
Topic :- Review on production and quality control
Under the guidance
Dr R. A sarkate sir
Submitted by
A. B. Tanveer patel

2. INTRODUCTION

3. Akola Chemicals, located in Akola, Maharashtra, was established 1981. Since then, we have grown grown into a
Nutrition Specialist producing hydrolyzed proteins for the Agricultural, Animal Feed, Food, Nutraceutical and
Cosmetics Industries.
Akola Chemicals manufacturing facilities are spread across two divisions:
Agro Division : manufactures plant and animal nutrition products from varied protein sources. This division is
licensed to manufacture Micronutrient Fertilizers
Speciality Chemicals Division : manufactures premium grade hydrolyzed proteins for the Food, Nutraceutical and
Cosmetic Industies. This division has facilities approved by the FDA and has FSSAI and cosmetic manufacturing
licenses.
Our management team is comprised of :
Vijay Rai - Chairman Emeritus
Karan Rai - Director
Ravi Vaishya - Research and Development
Aleem Mirza - Production

4. Akola Chemicals india Ltd. is a company, established in 1981, that promises good health for all by
providing quality medicines at affordable prices and committed to care the people for keeping good
health.
They have won many accolades in the domestic and international pharmaceutical domain.
They are engaged in manufacturing of pharmaceutical products for acute care market, etc.
➤ They are a leading group of companies that is headed by an experienced management involved in
the diverse field of pharma industry and is situated at the excise free zone in Maharashtra which is
conducive for a pharma industry to grow. ➤ Their commitment towards quality, rich industry experience
together with ethical business values

5. Honor our pledge to continuously improve and strive towards the highest quality
standards in all
aspects of our business. Optimize the talents of our employees within a learning
organization with an environment that
reward commitment, creativity, and performance. Value teamwork among our
employees, business associates, and customers as an integral factor
in our continued business success. Innovate continuously to develop new cutting-edge
pharmaceutical and healthcare technologies
and products.
▸ Dedicate ourselves to total customer satisfaction in order to consistently deliver
outstanding
value to our customer and stakeholders.
 2.2-MISSION.

6. 2.3-VISSION.
Our vision is to become a technology-based Indian pharmaceutical company & to emerge out
as a strong player in the domestic & international market. To keep improving the quality of life
by offering value-added novel products that are technologically innovative, cost-effective and of
superior quality, surpassing expectations of customers across the globe.
2.4-SOCIAL RESPONSIBILITY.
At Akola Chemicals Ltd we believe that contributing back to the society is not only a
RESPONSIBILITY but a COMMITMENT. Our little value added to the betterment of society is a
part of our mission, in line with our commitment to human health. Through the years, Elfin has
strived to make the world around it a better place. Corporate Social Responsibility (CSR) is not
just an integral part of our business but devotion; the promise of a brighter future for every life
we touch.
We consider it our duty to contribute a share of our carnings towards health benefits to the less
privileged, rural welfare to make life easier for rural poor and several charitable activities to do
our part towards the welfare of society as a whole.

7. Chairman
B.Tech in Mechanical Engineering from IIT, Kharagpur Over 44 years in diverse
industries including Industrial Chemicals, Pharmaceuticals and Engineering; Of
these, 30 years spent with Tata Group and in the last 12 years of his tenure here
he served as CEO of Rallis, India’s largest agrochemicals company Served as
Vice President of Bombay Chamber of Commerce & Industry and member of
several industry associations; Holds directorships in Punjab Chemicals and Crop
Protection Ltd, Akola Chemicals (India) Ltd, Greaves Cotton Ltd, Greaves Leasing
Finance Ltd, Sri Biotech Laboratories India Ltd, Pimex India Pvt Ltd, South India
Research Institute Pvt Ltd
 2.5-Key Personnel
 Vijay Rai (Chairman)

8. Executive Director
Bachelors in Computer Science from the University of Texas at
Austin Over 12 years of experience across various field
including the Manufacturing, Retail, Financial Services and
Management. Worked in consulting with both Mahindra
Special Services Group and KMPG. Working with Meckrai
since 2011
 Karan Rai Executive Director

9.  Company Contacts Details

10. akola chemicals is a pioneer in the development of
hydrolyzed proteins for agriculture in 1986 it started with
the first amino acid based plant growth promoter, a
mineral chelates mix
today akola chemicals make a range of products for
agriculture:
- consumer packs for distributors
- basic hydrolized for formulators and pgp manufacturers
 3.3-Products Details

11.  3.0-Production Section
• 3.1-General Instructions and Precautions –
•Ensure area and equipment cleanliness before starting the manufacturing operations.
Check and ensure that all manufacturing equipment and other required accessories are
clean
ready for use.
Wear gloves and nose mask during all manufacturing process.
Counter check the weights of all ingredients before using in the batch.
Get line clearance from QA for manufacturing.
Air handling unit (AHU) system should be kept ON throughout the manufacturing
process.
Temperature should be kept between 25 0C + 2 0C and relative humidity should be kept
between
50 + 10%.
Ensure that QC approval purified water is being used for manufacturing purpose.
Always transfer solution to the manufacturing vessels through 20 meshes.
During the preparation of product, no other product processing should be done in the
same area.

12. Whenever sifting through SS mesh is involved; check the mesh integrity before and after use.
All critical aspects during manufacturing like temperature, duration of mixing, weight, etc.
must
be checked and recorded by the supervisor.
Supervisor to ensure completion of all in-process records during various stages of
manufacturing
operations till completion of the batch.
Release from QA should be taken from all in-process tests mentioned in batch manufacturing
record.
No over writing is allowed in batch manufacturing record. If initial data is wrong entered,
cancel
the data by single stroke arrow and put initials. Record reasons for change as footnote on the
same page.
All details whatever is necessary should be recorded in batch manufacturing record (BMR).
Send a test request to QC after manufacturing is completed.
Check all polyethylene bags before and after material loading for black particles and sealing.
Check calibration of respective equipment/machine before use

14. • akola chemicals offers a full range of hydrolyzed
proteins for food supplementation and flavoring.
• protein supplement additives
• protein hydrolysates (proteinates) are
essentially amino acids that are absorbed
faster than intact proteins and so form a major
ingredient in food supplements for children,
adults and the elderly. akola has a range of
proteinates for the food sector.

15. • Akoprot Rice Supplement
• Rice protein offers additional benefits
over other proteins. Whey protein comes
from milk, and is expensive. Research has
tied rice protein to fat loss and lowered
cholesterol. Rice Protein is also unique in
its natural ability to promote satiety better
than carbohydrates or fats.
•
• Concentration : 50%
 Akoprot Rice Supplement

16. • Akoprot Soy Supplement
• The value of soy based proteins is well
known. They are widely used to
supplement health foods and drinks
and fortify milk. Hydrolyzed soy
protein is used in supplementing the
protein concentration of many health
foods. Soya protein concentrate C-60 is
for those who do not use hydrolyzed
products. It is used to fortify milk and
nutraceutical supplements. (Also
available in liquid form) Soy Protein
offers an alternative to meat and milk
proteins. The hydrolyzed protein is
easily absorbed into the human system
making it a popular food ingredient.
•
• Concentration : Concentrate 50%,
Hydrolyzed 55%
 Akoprot Soy Supplement

17. • Akoprot Collagen Supplement
• Hydrolyzed Collagen protein is
produced from Gelatin, which is
used to make capsules. It has high
amounts of glycine, lysine and
proline and such amino acids, which
are low in other food supplements.
Collagen amino acids mix generates
quicker cell growth as it makes more
connective tissue (very important for
senior food supplements as their
production diminishes after the age
of 40). Akoprot GS is a high
concentration collagen product.
•
• Concentration : 95%
 Akoprot Collagen
Supplement

18. • Akoprot Food Supplement
• Protein hydrolysates made from
the hydrolysis of a blend of high
quality proteins including
collegen, soy and rice. They
have excellent absorption
capabilities into the human
body.
•
• Concentration : 80%, 70%, 60%,
50%
 Akoprot Food Supplement

19. • Milk is made up of two major
proteins, the casein class and
the whey class. Caseinates are
made from the enzyme
hydrolysis of Casein (lactium)
and are used as food
supplements to improve
nutrition features, taste and
smell.
•
• Akoprot - Casein
• Mineral: Sodium or Calcium
Caseinates
• Concentration : 90%
 caseinates

20. • Food technologists have long been aware that protein
hydrolysis produces a unique bouillon-like flavour, a taste
known as "umami". variously described as "savoury" or
"earthy", umami has come to be recognized as the fifth
taste, after salty, sweet, sour and bitter. umami also has
the property of enhancing other flavours by imparting a
depth and fullness to them . Hydrolyzed Vegetable
Protein (HVP) is used as a substitue for monosodium
glutamate, to create savoury flavours and umami taste
sensations.
• HVP is hydrolyzed proteins combined with sodium salt
and is available from different proteins sources such as
soy, rice and groundnut
•
• HVP - S, R, G
• Protein Concentration : 30% - 60%
• Sodium Concentration : 30% - 50%
• Source: Soy, Rice, Groundnut
 hydrolyzed vegetable protein

21. • akola chemicals offers a range of hydrolyzed proteins and mineral chelates for
nutracutical formulations. proteins are the building blocks of the body.
proteins combine in different ways to make muscles, bone, tendons, skin, hair,
and other tissues. protein hydrolysates or proteinates are available from
different raw material. they are used as a base for supplements in diets or
health therapies, as their digestibility is significantly higher than that of raw
proteins. hydrolyzed protein have become important part of supplements as
hydrolysis breaks down proteins into peptides, smaller chains of molecules,
which are easily absorbed by the body. they are added into supplements for
many benefits and are ideal for food supplements required by sportsmen,
body builders, and others who required high concentrated protein diet.
 4.1-NUTRACUTICALS PRODUCTS

22. • AkoMass - Protien Rich Mass Gainer
• A formula which combines the essentials that is
hydrolyzed proteins with easy. The brain and
other organs need glucose in order to function,
and if not available amino acids get consumed.
People with the need to add weight can do so
without excess fat by taking a judicious
combination of proteins products. It can also
come together with minerals and vitamins and
suitable flavours.
•
• Protein Concentration : 40%
• Carbohydrate Concentration : 50%
• Flavor : Vanilla
• Source: Collagen
 consumer products

23. • Akoprot GS
• Hydrolyzed Collagen protein is
produced from Gelatin, which is
used to make capsules. It has high
amounts of glycine, lysine and
proline and such amino acids,
which are low in other food
supplements. Collagen amino acids
mix generates quicker cell growth
as it makes more connective tissue.
• Concentration : 95%
 4.2-industrial Formulations.

24. • Akoprot Rice
• made from rice bran, this hydrolysate
has become a popular ingredient of
food supplements. Rice protein helps
with recovery and gains in muscle after
exercise. It is also linked to fat loss.
Akoprot Rice protein contains the
essential amino acids which are not
easily synthesized within the human
body, thus need to be supplied by the
diet. Despite differences in the amino
acid profile to other protein sources, it
has been clinically shown as good as
whey at building muscle, strength &
aiding in exercise recovery.
•
• Concentration : 50%
 Akoprot Rice

25. • Akoprot Soy
• The value of soy based proteins is well
known. They are widely used to
supplement health foods and drinks
and fortify milk. Hydrolyzed soy
protein is used in supplementing the
protein concentration of many health
foods. Soy protein concentrate is for
those who do not use hydrolyzed
products. It is used to fortify milk and
nutraceutical supplements. (Also
available in liquid form) Soy Protein
offers an alternative to meat and milk
proteins. The hydrolyzed protein is
easily absorbed into the human system
making it a popular food ingredient.
•
• Concentration : Concentrate 50%,
Hydrolyzed 55%
 Akoprot Soy

26. • Akoprot Food Supplement
• Protein hydrolysates made from
the hydrolysis of a blend of high
quality proteins including
collegen, soy and rice. With a
high degree of hydrolysis they
have excellent absorption
capabilities. They are ideal for
food supplements required by
sportsmen, body builders, mass
gainers and others who required
high concentrated protein diet.
•
• Concentration : 80%, 70%, 60%,
 Akoprot Food Supplement

27. • Mineral Chelates
• Amino acids that have been bonded with
mineral ions. They are used in Nutraceuticals to
address mineral deficiencies. They are also used
in supplements in several multi vitamin and
mineral mixes and have a better absorption by
the human body than mineral salts
• Akoprot C - Mineral Chelates
• Minerals: Iron, Zinc, Manganes
• Other Amino acid chelates available are of
Calcium, Potassium, Copper, Boron, Cobalt,
Selenium, Chromium and Molybdenum. The
percentage of mineral is dependent on the
customer need and the physical limit of
chelation.We also supply a premix of
different minerals
 Akoprot C -

28. • cosmetic compositions containing the protein hydrolysates
show well defined activity in for treating and preventing
wrinkles, moisturizing the skin and hair, as well as,
thickening of the epidermis. it is used for ameliorating the
effect on skin which may be caused by environmental
hazards or by the natural aging. protein hydrolysates can
also be used to prevent and repair damaged hair and to
restructure and strengthen it. hydrolyzed protein (amino
acids) based products are used in skin and hair care
products. aola chemicals offers a range of speciality proteins
for cosmetic formulations
 5.1COSMETICS PRODUCTS.

29. • Almonds are considered to
be one of the most
nutritious nuts. Packed
with nutrients and
beneficial compounds,
Almonds help maintain
heart and skin health. They
are used widely across the
globe as a principal
ingredient in many
healthcare and skincare
products.
•
• Source: Almond
• Form : Liquid, Paste
 almond protein

30. • It is revered in Ayurveda and is a
known to act as an anti-oxidant and
hair growth promoter. It is highly
nutritious and is an important source
of vitamin C, minerals and amino acids.
It contains three times the vitamin C
(ascorbic acid) and protein
concentration than apple. They work
together to enhance immunity,
rejuvenate skin. Amla nourishes body
tissues and accelerates the cell
regeneration process. Amla helps
scavenge free radicals linked to
premature aging.
•
• Source : Amla
• Form : Powder
 amla protein.

31. • Made from coconut
protein solids it is rich in
special amino acids which
are good for healthy hair
growth. Apart from
boosting hair growth, it is
good for countering
dandruff, hair fall, and
greying. It has also been
observed that use of CMP
on hair can make your
mane softer.
•
• Source : Coconut
• Form : Powder
 coconut milk
protein

32. • Made from hair it is the most
effective product for hair care.
Over time hair weakens due to
heat, styling, and environment
Keratin is used to smoothen and
fill in the damaged part of the
hair's cuticle layer. It gives it
strength and keeps the strands
looking smooth. Keratin unlike a
perm or relaxer doesn't actually
change the hair's texture but
fills in the gaps. By filling the
voids and adding moisture it
restores hair and maintains its
elasticity.
•
• Source : Hair
 keratin protein

33. • Hydrolyzed collagen is made from
pharmaceutical grade gelatin. It plays
an important role in the health of hair
and nails. With age, the natural ability
to produce supporting amounts of
connective tissue diminishes. The
collagen in the skin, especially in the
facial and neck area, begins to
degrade, resulting in wrinkles and dry
skin. Hydrolyzed Collagen is unique as
it contains high amounts of glycine,
lysine and proline, which are lower in
other proteins. These amino acids
benefit hair, skin tissue and nail cell
growth. Some doctors are referring to
this product as the new anti-aging
product of the century
•
• Source : Gelatine
• Form : Liquid, Powder
 collagen protein

34.  8.0-CONCLUSION
• Industrial training is very much essential for Pharmacy Students. It is also a great
opportunity to acquire practical knowledge. During my training period, in the
industry I acquired lots of experiences in Pharmaceutical Production and
Production management. This will help me to clarify my theory knowledge. I hope
and pray that it will help me much in my future profession.
• During our training period, we had seen the various instruments and apparatus in
the industry. The highly sophisticated instruments that work precisely must be
operated with intense care for optimum use. We could acquire a lot of
information regarding the latest instruments and their working procedures.
• It was taught to us that, the CGMP guidelines are to be strictly followed in the
industries in each and every section. And the similar guideline was seen followed
in Akola Chemicals india Ltd., Akola, Maharashtra. It helped us to acquire
knowledge on punctuality, regularity and working environments in industries.
• The friendly working environment in Akola Chemicals (india) Ltd. will remain in our
mind in near future. Hence, we can say that our goal of attending the industrial
tour is fulfilled. We acknowledge the great help "Akola Chemical India Ltd".

35.  Presented by Abdul
Tanveer Patel
 B.Pharm Final year student.
Thank You.