Drug Discovery Data Insights with Andrew Leach (ChEMBL), Evan Bolton (PubChem...Lixin Liu
The emergence of freely available PubChem and ChEMBL resources for chemical and biological Structure-Activity-Relationship (SAR) data has radically changed the global drug discovery informatics landscape. The heterogeneity of low throughput and high throughput chemical and biological data do nevertheless present some unique challenges – and opportunities – when creating large-scale community resources – for sophisticated purveyors of drug discovery data.
Slides from CDD's March 22 Webinar - Penetrating Gram Negative Bacteria. Hosted by Brad Sherborne (Merck) featuring Derek Tan (Memorial Sloan Kettering Cancer Center) and Helen Zgurskaya (University of Oklahoma).
Antibiotic Discovery Webinar – Getting Through the Discovery WallLixin Liu
Slides from CDD's Q3 webinar where Dr. Lynn Silver and Dr. Johannes Zuegg (CO-ADD) tackle the increasingly difficult task of finding new, effective antibiotics. Moderated by Joe Thomas, The Pew Charitable Trusts.
Collaborative Drug Discovery Inc, webinar slides. Learn about best practices from Dr. Nathan Coussens (Assay Guidance Manual, Associate Scientific Editor) and hear how Professor Paul Roepe (Georgetown) tackles the problem given the complexity of Malaria biology.
Human vs. Machine-Enhanced Scientific DiscoveryLixin Liu
This document summarizes a webinar titled "Human vs. Machine-Enhanced Scientific Discovery" hosted by Collaborative Drug Discovery, Inc. on September 21, 2016. It introduces the moderators and panelists which include experts from CDD, University of Miami, Stanford University, and biotech consultants. The webinar then discusses topics like semantic web, ontologies, controlled vocabularies, challenges of semantic annotation, and visions of future laboratory research. Resources like Protégé, BioPortal, CEDAR, BAO, LINCS, and DTO are also presented. Questions from attendees are addressed at the end.
Slides from CDD's Q4 webinar. Dr. Dale Kempf (AbbVie), Dr. Ben Gold (Weill Cornell Medical College) and Dr. Peter Warner (Bill and Melinda Gates Foundation) discuss the current state of Tuberculosis (TB) research.
DayOne Experts - Next generation clinical trialsDayOne
Event introduction slides by Thomas Brenzikofer.
Read the event report here:https://www.baselarea.swiss/baselarea-swiss/channels/innovation-report/2019/06/on-the-verge-of-being-born-next-generation-clinical-trials.html
Tomasz Sablinski, Founder and CEO of Transparency Life Sciences raised the crunch question of the evening: Which industry is lagging behind the most in terms of digitization? Right, it is the healthcare industry! But who would have expected the usual lamentation of why this is the case; blaming regulatory constraints, scarce innovation culture, or unachievable technology barriers proved wrong. The appetite for change and finding new ways of doing things was too strong among Basel’s Healthcare innovators at the DayOne Expert Session on “Next Generation Digital Trials”.
The idea of the event was to present a holistic view of the current standing in the digitizing clinical trials.
Drug Discovery Data Insights with Andrew Leach (ChEMBL), Evan Bolton (PubChem...Lixin Liu
The emergence of freely available PubChem and ChEMBL resources for chemical and biological Structure-Activity-Relationship (SAR) data has radically changed the global drug discovery informatics landscape. The heterogeneity of low throughput and high throughput chemical and biological data do nevertheless present some unique challenges – and opportunities – when creating large-scale community resources – for sophisticated purveyors of drug discovery data.
Slides from CDD's March 22 Webinar - Penetrating Gram Negative Bacteria. Hosted by Brad Sherborne (Merck) featuring Derek Tan (Memorial Sloan Kettering Cancer Center) and Helen Zgurskaya (University of Oklahoma).
Antibiotic Discovery Webinar – Getting Through the Discovery WallLixin Liu
Slides from CDD's Q3 webinar where Dr. Lynn Silver and Dr. Johannes Zuegg (CO-ADD) tackle the increasingly difficult task of finding new, effective antibiotics. Moderated by Joe Thomas, The Pew Charitable Trusts.
Collaborative Drug Discovery Inc, webinar slides. Learn about best practices from Dr. Nathan Coussens (Assay Guidance Manual, Associate Scientific Editor) and hear how Professor Paul Roepe (Georgetown) tackles the problem given the complexity of Malaria biology.
Human vs. Machine-Enhanced Scientific DiscoveryLixin Liu
This document summarizes a webinar titled "Human vs. Machine-Enhanced Scientific Discovery" hosted by Collaborative Drug Discovery, Inc. on September 21, 2016. It introduces the moderators and panelists which include experts from CDD, University of Miami, Stanford University, and biotech consultants. The webinar then discusses topics like semantic web, ontologies, controlled vocabularies, challenges of semantic annotation, and visions of future laboratory research. Resources like Protégé, BioPortal, CEDAR, BAO, LINCS, and DTO are also presented. Questions from attendees are addressed at the end.
Slides from CDD's Q4 webinar. Dr. Dale Kempf (AbbVie), Dr. Ben Gold (Weill Cornell Medical College) and Dr. Peter Warner (Bill and Melinda Gates Foundation) discuss the current state of Tuberculosis (TB) research.
DayOne Experts - Next generation clinical trialsDayOne
Event introduction slides by Thomas Brenzikofer.
Read the event report here:https://www.baselarea.swiss/baselarea-swiss/channels/innovation-report/2019/06/on-the-verge-of-being-born-next-generation-clinical-trials.html
Tomasz Sablinski, Founder and CEO of Transparency Life Sciences raised the crunch question of the evening: Which industry is lagging behind the most in terms of digitization? Right, it is the healthcare industry! But who would have expected the usual lamentation of why this is the case; blaming regulatory constraints, scarce innovation culture, or unachievable technology barriers proved wrong. The appetite for change and finding new ways of doing things was too strong among Basel’s Healthcare innovators at the DayOne Expert Session on “Next Generation Digital Trials”.
The idea of the event was to present a holistic view of the current standing in the digitizing clinical trials.
Domainex Ark Press Release June 2009 Finaldikheidi
Domainex Ltd and Ark Therapeutics have extended their drug discovery agreement. Domainex will continue providing hit-finding and lead optimization services for Ark's therapeutic targets. The companies have worked together successfully for years, combining Domainex's drug design expertise with Ark's disease expertise. Dr. Trevor Perrior of Domainex commented that their collaboration has already achieved breakthroughs against challenging goals, and they look forward to further developing programs to deliver new disease treatments.
10th International Conference Compound Libraries 2014Torben Haagh
VISIT THE CONFERENCE WEBSITE HERE:
http://bit.ly/CompoundLibrariesSlideshare
Maximizing information in early-phase R&D for an optimal library design and target selection
We are excited to conduct the 10th annual meeting of the formerly known Compound Libraries conference! Over the last decade we have provided the pharmaceutical R&D community with a wonderful platform for exchanging knowledge and ideas about how best to optimize the qualification of drug candidates.
We have hosted almost all major pharmaceutical companies and heard dozens of case-studies relating to important and acute issues. When returning back to the programs from previous years, it is interesting to look at the timeline of changing approaches, trends and market-related developments. Our topical spectrum ranged from compound management and acquisition to collaboration frameworks, open access, library design, screening and analysis.
This year we bring you 15 case studies about the most burning issues in early-stage discovery today and offer you a valuable trend-analysis and networking with peers and colleagues from pharmaceutical companies, biotechs, CROs and academic research institutes.
Don’t miss our 10th anniversary and join us in Berlin to take part at our legacy conference!
Benefit from participating in discussions about the following topics:
-10 years perspective on synthesizing and designing compound libraries
-What is the role of ligand efficiency metrics in drug discovery? Have your say in this controversial debate!
-Next generation library design - working towards better PPI and epigenetic libraries
-Exploration of bioactive and novel chemical space by application of privileged structure concept design
-Learn from Janssen’s experience with the assembly of the IMI European Lead Factory (ELF) library
-What is the real potential of macrocycles and are they the drugs of the future?
How Effective Are The Supplements I'm Taking (request for participants)HEMA Biosciences
The document summarizes a study comparing the effectiveness of over-the-counter omega-3 supplements to personalized omega-3 supplements from Hemavault. 20 participants were split into two groups, one taking OTC supplements and one taking Hemavault supplements, and had their omega-3 levels tested monthly over 12 weeks. Initial results found the Hemavault supplements led to higher omega-3 level increases for more participants, with one participant seeing a 36% increase. The document calls for more participants to help determine the relative effectiveness of different omega-3 supplement options and individuals' responses.
Agile Day Twin Cities - Lightning Talk (Repko)Brian Repko
This document discusses product agility when developing treatments for diseases like cancer. It describes the complex and iterative process of drug discovery and development at Novartis, involving thousands of experiments, assays, and clinical trials across multiple sites. It emphasizes the need for continuous learning, visualizing complexity through various data sources, forming product teams of different experts, planning experiments to learn key scientific questions, and collaborating to clarify goals and explore new approaches. The overall process involves blending discovery work with clinical evaluation in an agile manner to efficiently gain knowledge and progress potential new treatments.
The document discusses BRAID D4, a new initiative across the University of California system aimed at leveraging shared resources to enable drug and device discovery. The goals are to catalyze innovation that enhances development and testing of diagnostics and therapeutics. It notes challenges in translating research into clinical applications. D4 could help projects progress through the difficult period of late-stage preclinical development known as the "Valley of Death". The document outlines existing drug discovery resources at several UC campuses and a consensus to define D4's role in supporting the broader BRAID initiative through strategic planning.
Excipient Knowledge Management Mumbai 12 March 2015 Part 1 & 2Ajaz Hussain
Ajaz Hussain discusses the importance of excipient knowledge management, particularly regarding physical functionality and performance. He notes that many drug products now require precise control of complex material attributes supplied by excipients. Effective knowledge management is needed to understand and control excipient variability. Hussain also highlights current regulatory trends and the need to improve databases on inactive ingredients to better track excipient functionality.
Therapeutic Equivalence in Inequality and Our Quality ScorecardAjaz Hussain
I believe, and I know, that we can build and maintain effective pharmaceutical quality management systems (pQMS) when every pharmaceutical professional is empowered to contribute to improving the system they work in. A way I know to improve a pQMS from within is to illuminate paths to professional development for all to leverage “fractals” at every level and in every corner. This presentation describes my experiential learning to explain why I know so, how do I know what I know, and what you can do to verify or validate it at your level and in your corner.
Preliminary program of ISPOR Boston 2017Bruno Vayssié
This document provides information about the upcoming ISPOR Boston conference on health economics and outcomes research (HEOR). Some key points:
- The conference will be held from May 20-24, 2017 in Boston, MA and is expected to attract nearly 3,800 attendees from over 80 countries.
- It will feature over 1,850 presentations on topics related to HEOR including modeling, economic evaluation, patient preferences, real-world evidence, and health policy decision making.
- Plenary sessions will address pressing issues in US health policy, using social networks to impact population health, and the need for randomized controlled trials.
- Pre-meeting short courses and educational symposia are also offered to enhance
NIPTE, A Community of Knowledge at 2019 Research ConferenceAjaz Hussain
The nation’s “Pharmaceutical Technology” faculty: Distributed (as it should be) but sparsely, integrated with NIPTE
Nation’s attention on its pharmaceutical technology faculty
Increasing awareness of threats and vulnerabilities
Impactful solutions
The NIPTE Model: Team Science & Education for Pharmaceuticals
Integrating systems: Solutions for the real-world
How to Build Effective Pharmaceutical Quality Managment System & Self-develop...Ajaz Hussain
Building on the goals of your LIU education and training, we will learn how the Experience Economy has already changed and will continue to change, the healthcare and new drug pricing and development model and how it is impacting generic drugs.
We will use the ICH Q10 model and adopt a system within a system framework to identify common effectiveness measures – Assurance, Availability, Adherence, and Affordability to understand how these may relate improvement of a system and development of individuals (Amgen case example). Finally, we will outline an easy to use/remember framework that we can use as a starting point in writing their a self- development plan.
A presentation delivered by IPPOSI CEO, Derick Mitchell at the University College Dublin PharmTox Society event on Clinical Trials in Ireland on March 6th, 2017
Bill & Melinda Gates foundation - Ken Duncanbluesquare
The document discusses partnerships in drug discovery for diseases that primarily impact developing countries. It focuses on the importance of partnerships like the TB Drug Accelerator (TBDA) in developing new treatments for tuberculosis. The TBDA is a partnership between pharmaceutical companies and research institutions that aims to develop a new one-month drug regimen for TB through open data sharing, collaborative research, and ensuring the best candidates advance. Such partnerships are a new paradigm that can help address bottlenecks in developing new TB drugs and serve as a model for other disease areas.
5 Ways Healthcare Brands Can Stand out to HCPs in the Digital EcosystemDRG Digital
Learn 5 ways healthcare brands can stand out to physicians in the digital ecosystem:
- Key physician trends and best practices you need to know for more effective campaigns
- New Manhattan Research Taking the Pulse® physician study findings
Views for collaboration between pharmaceutical industry and academia a haapal...Antti Haapalinna
The document discusses views on collaboration between the pharmaceutical industry and academia from Antti Haapalinna, Vice President of Research and Development at Orion Corporation. It notes that strategic partnerships can cover the entire R&D chain from early discovery to late-stage clinical development and marketing. Early-stage partnerships are often with smaller organizations that provide specific expertise to complement larger companies. Later-stage partnerships are usually with larger organizations for their clinical trial expertise and global reach. Key success factors include a mutual desire to develop new treatments, each party contributing unique capabilities, and professionally coordinated collaboration.
This document provides information about sponsoring the Minority Biomedical Entrepreneurship Conference (MBEC) taking place May 21-22, 2012 in Cleveland, Ohio. The MBEC is the first national conference focused on increasing minority participation and competitiveness in the biomedical industry. Sponsorship opportunities range from platinum ($15K) to bronze
Pistoia Alliance Debates: Text Mining for Pharma R&D in a Social World (17th ...Pistoia Alliance
Text-mining of journal articles and other publications has long been a subject of interest. It already has applications across R&D and beyond into health care, for instance by analysing electronic health records. The technology has value but also has its limits. With new sources of text to mine becoming mainstream, such as Twitter feeds or Facebook posts that might reference a company’s brand or a drug’s efficacy or adverse events, existing technology needs to be adapted to keep pace. Not only that, but whole new compliance questions arise: does a fleeting mention on Twitter require the same response as a formal notification of an adverse event?
Genetic Alliance is the nonprofit health advocacy organization committed to improving health through authentic engagement of communities and individuals.
Visit: http://www.geneticalliance.org/
Insight-driven Medical Communications – Educating NeurologistsMedicalwriters.com
Presentation given by Wesley Portegies, CEO of Medicalwriters.com, at the 2018 Drug Information Association (DIA) annual meeting in Boston, MA.
In order to develop effective Medical Education programs and materials, it is crucial to have a thorough understanding of the behavior, perceptions, and beliefs of your target audience. This presentation focuses on how you can use these insights to optimize your communications to Health Care Professionals (HCPs).
Presentation on current state of pharmaceutical drug research and ideas for change. It addresses how the pharmaceutical industry, NIH, Government, HealthCare Law, OIG, Public Health
This conference offers delegates an in-depth view of the latest initiatives that are simplifying and improving the clinical trial experience for the patient through data-sharing and setting industry standards. Leading individuals from biopharma partnerships and consortia come together to share the results and impact of their projects, as well as insights on areas ripe for future collaboration. The conference provides delegates with opportunities to learn from one another in regard to what works now and a forum to discuss how to leverage and build on collective experiences to advance innovation across the wider community.
We discuss:
Responsible Clinical Trials Data Sharing – Protecting Intellectual Property While Enabling Public Access to Data.
The Project Data Sphere Initiative – A New Data Sharing and Analytics Model for Cancer Research.
Clinical Trials Transformation Initiative – Advancing Central IRBs, IND Safety and a Quality by Design Approach to Clinical Trial Operations.
Lessons Learned from Pilot Studies on Risk-Based Monitoring Methodology to Identify Risk and Ensure Data Quality.
A Model to Create, Share, and Re-Use Structured Content throughout the Clinical Trial Life Cycle – The Sanofi-TransCelerate Collaboration.
CISCRP Recommendations – Communicate Trial Results to Participants to Improve Experience and Build Support for the Clinical Research Enterprise.
http://www.worldcongress.com/events/PB14014/
Domainex Ark Press Release June 2009 Finaldikheidi
Domainex Ltd and Ark Therapeutics have extended their drug discovery agreement. Domainex will continue providing hit-finding and lead optimization services for Ark's therapeutic targets. The companies have worked together successfully for years, combining Domainex's drug design expertise with Ark's disease expertise. Dr. Trevor Perrior of Domainex commented that their collaboration has already achieved breakthroughs against challenging goals, and they look forward to further developing programs to deliver new disease treatments.
10th International Conference Compound Libraries 2014Torben Haagh
VISIT THE CONFERENCE WEBSITE HERE:
http://bit.ly/CompoundLibrariesSlideshare
Maximizing information in early-phase R&D for an optimal library design and target selection
We are excited to conduct the 10th annual meeting of the formerly known Compound Libraries conference! Over the last decade we have provided the pharmaceutical R&D community with a wonderful platform for exchanging knowledge and ideas about how best to optimize the qualification of drug candidates.
We have hosted almost all major pharmaceutical companies and heard dozens of case-studies relating to important and acute issues. When returning back to the programs from previous years, it is interesting to look at the timeline of changing approaches, trends and market-related developments. Our topical spectrum ranged from compound management and acquisition to collaboration frameworks, open access, library design, screening and analysis.
This year we bring you 15 case studies about the most burning issues in early-stage discovery today and offer you a valuable trend-analysis and networking with peers and colleagues from pharmaceutical companies, biotechs, CROs and academic research institutes.
Don’t miss our 10th anniversary and join us in Berlin to take part at our legacy conference!
Benefit from participating in discussions about the following topics:
-10 years perspective on synthesizing and designing compound libraries
-What is the role of ligand efficiency metrics in drug discovery? Have your say in this controversial debate!
-Next generation library design - working towards better PPI and epigenetic libraries
-Exploration of bioactive and novel chemical space by application of privileged structure concept design
-Learn from Janssen’s experience with the assembly of the IMI European Lead Factory (ELF) library
-What is the real potential of macrocycles and are they the drugs of the future?
How Effective Are The Supplements I'm Taking (request for participants)HEMA Biosciences
The document summarizes a study comparing the effectiveness of over-the-counter omega-3 supplements to personalized omega-3 supplements from Hemavault. 20 participants were split into two groups, one taking OTC supplements and one taking Hemavault supplements, and had their omega-3 levels tested monthly over 12 weeks. Initial results found the Hemavault supplements led to higher omega-3 level increases for more participants, with one participant seeing a 36% increase. The document calls for more participants to help determine the relative effectiveness of different omega-3 supplement options and individuals' responses.
Agile Day Twin Cities - Lightning Talk (Repko)Brian Repko
This document discusses product agility when developing treatments for diseases like cancer. It describes the complex and iterative process of drug discovery and development at Novartis, involving thousands of experiments, assays, and clinical trials across multiple sites. It emphasizes the need for continuous learning, visualizing complexity through various data sources, forming product teams of different experts, planning experiments to learn key scientific questions, and collaborating to clarify goals and explore new approaches. The overall process involves blending discovery work with clinical evaluation in an agile manner to efficiently gain knowledge and progress potential new treatments.
The document discusses BRAID D4, a new initiative across the University of California system aimed at leveraging shared resources to enable drug and device discovery. The goals are to catalyze innovation that enhances development and testing of diagnostics and therapeutics. It notes challenges in translating research into clinical applications. D4 could help projects progress through the difficult period of late-stage preclinical development known as the "Valley of Death". The document outlines existing drug discovery resources at several UC campuses and a consensus to define D4's role in supporting the broader BRAID initiative through strategic planning.
Excipient Knowledge Management Mumbai 12 March 2015 Part 1 & 2Ajaz Hussain
Ajaz Hussain discusses the importance of excipient knowledge management, particularly regarding physical functionality and performance. He notes that many drug products now require precise control of complex material attributes supplied by excipients. Effective knowledge management is needed to understand and control excipient variability. Hussain also highlights current regulatory trends and the need to improve databases on inactive ingredients to better track excipient functionality.
Therapeutic Equivalence in Inequality and Our Quality ScorecardAjaz Hussain
I believe, and I know, that we can build and maintain effective pharmaceutical quality management systems (pQMS) when every pharmaceutical professional is empowered to contribute to improving the system they work in. A way I know to improve a pQMS from within is to illuminate paths to professional development for all to leverage “fractals” at every level and in every corner. This presentation describes my experiential learning to explain why I know so, how do I know what I know, and what you can do to verify or validate it at your level and in your corner.
Preliminary program of ISPOR Boston 2017Bruno Vayssié
This document provides information about the upcoming ISPOR Boston conference on health economics and outcomes research (HEOR). Some key points:
- The conference will be held from May 20-24, 2017 in Boston, MA and is expected to attract nearly 3,800 attendees from over 80 countries.
- It will feature over 1,850 presentations on topics related to HEOR including modeling, economic evaluation, patient preferences, real-world evidence, and health policy decision making.
- Plenary sessions will address pressing issues in US health policy, using social networks to impact population health, and the need for randomized controlled trials.
- Pre-meeting short courses and educational symposia are also offered to enhance
NIPTE, A Community of Knowledge at 2019 Research ConferenceAjaz Hussain
The nation’s “Pharmaceutical Technology” faculty: Distributed (as it should be) but sparsely, integrated with NIPTE
Nation’s attention on its pharmaceutical technology faculty
Increasing awareness of threats and vulnerabilities
Impactful solutions
The NIPTE Model: Team Science & Education for Pharmaceuticals
Integrating systems: Solutions for the real-world
How to Build Effective Pharmaceutical Quality Managment System & Self-develop...Ajaz Hussain
Building on the goals of your LIU education and training, we will learn how the Experience Economy has already changed and will continue to change, the healthcare and new drug pricing and development model and how it is impacting generic drugs.
We will use the ICH Q10 model and adopt a system within a system framework to identify common effectiveness measures – Assurance, Availability, Adherence, and Affordability to understand how these may relate improvement of a system and development of individuals (Amgen case example). Finally, we will outline an easy to use/remember framework that we can use as a starting point in writing their a self- development plan.
A presentation delivered by IPPOSI CEO, Derick Mitchell at the University College Dublin PharmTox Society event on Clinical Trials in Ireland on March 6th, 2017
Bill & Melinda Gates foundation - Ken Duncanbluesquare
The document discusses partnerships in drug discovery for diseases that primarily impact developing countries. It focuses on the importance of partnerships like the TB Drug Accelerator (TBDA) in developing new treatments for tuberculosis. The TBDA is a partnership between pharmaceutical companies and research institutions that aims to develop a new one-month drug regimen for TB through open data sharing, collaborative research, and ensuring the best candidates advance. Such partnerships are a new paradigm that can help address bottlenecks in developing new TB drugs and serve as a model for other disease areas.
5 Ways Healthcare Brands Can Stand out to HCPs in the Digital EcosystemDRG Digital
Learn 5 ways healthcare brands can stand out to physicians in the digital ecosystem:
- Key physician trends and best practices you need to know for more effective campaigns
- New Manhattan Research Taking the Pulse® physician study findings
Views for collaboration between pharmaceutical industry and academia a haapal...Antti Haapalinna
The document discusses views on collaboration between the pharmaceutical industry and academia from Antti Haapalinna, Vice President of Research and Development at Orion Corporation. It notes that strategic partnerships can cover the entire R&D chain from early discovery to late-stage clinical development and marketing. Early-stage partnerships are often with smaller organizations that provide specific expertise to complement larger companies. Later-stage partnerships are usually with larger organizations for their clinical trial expertise and global reach. Key success factors include a mutual desire to develop new treatments, each party contributing unique capabilities, and professionally coordinated collaboration.
This document provides information about sponsoring the Minority Biomedical Entrepreneurship Conference (MBEC) taking place May 21-22, 2012 in Cleveland, Ohio. The MBEC is the first national conference focused on increasing minority participation and competitiveness in the biomedical industry. Sponsorship opportunities range from platinum ($15K) to bronze
Pistoia Alliance Debates: Text Mining for Pharma R&D in a Social World (17th ...Pistoia Alliance
Text-mining of journal articles and other publications has long been a subject of interest. It already has applications across R&D and beyond into health care, for instance by analysing electronic health records. The technology has value but also has its limits. With new sources of text to mine becoming mainstream, such as Twitter feeds or Facebook posts that might reference a company’s brand or a drug’s efficacy or adverse events, existing technology needs to be adapted to keep pace. Not only that, but whole new compliance questions arise: does a fleeting mention on Twitter require the same response as a formal notification of an adverse event?
Genetic Alliance is the nonprofit health advocacy organization committed to improving health through authentic engagement of communities and individuals.
Visit: http://www.geneticalliance.org/
Insight-driven Medical Communications – Educating NeurologistsMedicalwriters.com
Presentation given by Wesley Portegies, CEO of Medicalwriters.com, at the 2018 Drug Information Association (DIA) annual meeting in Boston, MA.
In order to develop effective Medical Education programs and materials, it is crucial to have a thorough understanding of the behavior, perceptions, and beliefs of your target audience. This presentation focuses on how you can use these insights to optimize your communications to Health Care Professionals (HCPs).
Presentation on current state of pharmaceutical drug research and ideas for change. It addresses how the pharmaceutical industry, NIH, Government, HealthCare Law, OIG, Public Health
This conference offers delegates an in-depth view of the latest initiatives that are simplifying and improving the clinical trial experience for the patient through data-sharing and setting industry standards. Leading individuals from biopharma partnerships and consortia come together to share the results and impact of their projects, as well as insights on areas ripe for future collaboration. The conference provides delegates with opportunities to learn from one another in regard to what works now and a forum to discuss how to leverage and build on collective experiences to advance innovation across the wider community.
We discuss:
Responsible Clinical Trials Data Sharing – Protecting Intellectual Property While Enabling Public Access to Data.
The Project Data Sphere Initiative – A New Data Sharing and Analytics Model for Cancer Research.
Clinical Trials Transformation Initiative – Advancing Central IRBs, IND Safety and a Quality by Design Approach to Clinical Trial Operations.
Lessons Learned from Pilot Studies on Risk-Based Monitoring Methodology to Identify Risk and Ensure Data Quality.
A Model to Create, Share, and Re-Use Structured Content throughout the Clinical Trial Life Cycle – The Sanofi-TransCelerate Collaboration.
CISCRP Recommendations – Communicate Trial Results to Participants to Improve Experience and Build Support for the Clinical Research Enterprise.
http://www.worldcongress.com/events/PB14014/
DIA Global Forum: Are Clinical Trials Ready to Embrace the IoE?Jackie Brusch
The Internet of Everything (IoE) is having a major impact across many industries by connecting people, processes and data on a single network. The IoE brings opportunities to make clinical trials more efficient, cost-effective and less intrusive by enabling devices, sensors and applications to connect to healthcare systems via the internet. This allows for remote patient monitoring and the collection of real-time objective data from devices and wearables. The constant flow of rich data allows investigators to remotely manage patients' health, which has potential to speed up drug development times. However, clinical trials have yet to fully embrace the IoE and changes may be needed to regulations and processes to realize the IoE's benefits for research.
The document discusses how True Open Innovation and Boston Strategics' global network can improve drug development efficiency and lower costs. It outlines challenges in the pharmaceutical industry like decreased productivity and increased costs. It then describes how Boston Strategics uses a virtualized model and worldwide expert network to assemble project teams that can progress drug candidates through development faster and at lower expense than traditional models. Examples are provided of projects demonstrating savings of time and money. The goal is to establish an open innovation platform to facilitate drug development collaborations globally.
A presentation delivered by IPPOSI CEO, Derick Mitchell at the Irish Brain Council-Neurological Allinace of ireland joint event in the Science Gallery, Dublin on March 7th, 2017.
The document summarizes a national summit on preventing pharmaceutical waste held on October 19, 2010. The summit, organized by the Product Stewardship Institute, brought together stakeholders to develop policy recommendations for reducing unused and unwanted pharmaceuticals in homes and healthcare facilities. Participants discussed approaches like short-cycle dispensing of initial prescriptions and use of vouchers instead of samples to minimize waste, and debated the pros and cons of different voluntary or mandated policies across various contexts. The goal was to identify next steps and strategies for widespread adoption of approaches to prevent pharmaceutical waste.
Similar to Industrial and Academic Neglected Disease Drug Discovery Collaborations - CDD Webinar (20)
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...Travis Hills MN
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
The debris of the ‘last major merger’ is dynamically youngSérgio Sacani
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
ESPP presentation to EU Waste Water Network, 4th June 2024 “EU policies driving nutrient removal and recycling
and the revised UWWTD (Urban Waste Water Treatment Directive)”
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...Leonel Morgado
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxMAGOTI ERNEST
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.