This document provides information about the phases of clinical drug trials and some Indian research institutions that conduct these trials. It includes: - An overview of the 5 phases of clinical drug trials from pre-clinical through post-marketing surveillance. - Brief descriptions of some top Indian research institutions that perform clinical drug trials including the Central Drug Research Institute in Lucknow and the Indian Veterinary Research Institute in Izatnagar. - A table listing common chemical reactions and the products they form from primary, secondary, and tertiary alcohols and other functional groups.

1. Disulifram

2. Phase 0 Phase 1 Phase 2 Phase 3 Phase 4
Pre clinical
Microdosing
Clinical phase Therapeutic
excploratory
Theraptuic
Confirmatory
Post marke
survelliacne
Synonym
Animal Healthy
volunteers
Diseases Disease volunteers Type
10-30 30-300 300-3000 No of
NCE/NME INDA
Investiagonatol
NDA(Branded Non
generic proportiarty
/ANDA(generic /Non
PropRITARY) generic BE
STUDIES NO CLINCAL
TRIALS
imp
Screening Safety Safety and Efficacy Efficacy and safety ADR PV Purpose

3. CDL:Kolkata
CDRI: Luckhnow
IVRI:Izzatnagar

5. Grignard
Wolff kishner
Clemmeson
Kolbe
Wurtz
Hoffmann broamide
Fittig
Wurtz fittig
Reimer Tiemann
Primary alchol ALDEHYDE
Secondary Ketone
Tertitrary (Na2cr2o7,k2cr2o7,Kmno4 ,Cro3) Alkene Ketone

6. Drug Category Subcategroy Chemica Biological Synonym Miscellaneous Use
Aloe Glycosides Anthraquinon
e/C glyco
Aloin
Barbaloin
Mussabar
kumari

7. Night blindness

8. Eutetic
• Hygroscopic • Efflorescne • Deliquescent

9. All tests (Biochem,Cognosy)
Alklaoids Glycosides Flvanaoids Volatiles Resings Carbohydr
ates
proteins Fats Miscellaneous Steroids
Mayer
wagner
Hager
dragender
off
Borntager
Modiefied
brontager
Shinoda
Vanillin
h2so4
Sudan red
3
Tincture
alkana
Vanilin-hCl
Gambier
fluroescie
Umbellifer
one
,Molisch Biuret
Ninhydrin
Sapo
Iodine
acid
Reiche
r
miesee
Polens
ki
Ruthenium red
Phlorgucniol
conc hcl
Cuoxam
PIcirc acid
Liberbman
n
salkwoski
Meconci
acid
Kedde
kller killian
Bnedict Xanthorp
teic
Vitalis
morin
bAlijet Barfoed Hopkin
cole
Murexide Raymond Seliwaniff Millon
Thallequin Legal Fwhling Paulys
Iodine Sagakuch
i
OSazone
Tollen