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The Inflammation Management Intervention: Associations between the
Dietary Inflammatory Index and Baseline Lipids
Taylor Lamia, Dr. Michael Wirth
South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina
Introduction
Methods
Results Conclusions
An increasing amount of evidence links chronic
inflammation to nearly all chronic diseases with
diet being a strong modulator of chronic,
systemic inflammation. In order to analyze one’s
inflammatory potential, epidemiologists at the
University of South Carolina created the Dietary
Inflammatory Index (DII)TM
. “The goal in
creating the original DII in 2009 was to provide
a tool that could categorize individual’s diets on
a continuum from maximally anti-inflammatory
to maximally pro-inflammatory” (Shivappa, et al.
2014). It was hypothesized that higher (i.e., more
pro-inflammatory) baseline DII scores will be
associated with higher lipid levels (total
cholesterol, triglycerides, high [HDL] and low
[LDL] density lipoprotein) compared to those
with lower (i.e., more anti-inflammatory) DII
scores.
Study Population To assess reduction in
inflammation using the DII and other health
behaviors of middle-aged adults who are at risk for
chronic disease, the University of South Carolina
Cancer Prevention and Control Program developed
an inflammation management intervention study
that is a currently ongoing, non-randomized, two-
arm intervention study of 93 individuals (34
control; 59 intervention). The intervention is a
combination of efforts to reduce chronic
inflammation levels:
 DII-based nutrition modifications
 Physical activity management
 Stress management
The intervention met weekly for 12 weeks and
monthly for the remaining 9 months. After the
12-week mark, participants are given access to the
web application where they are able to track dietary
information, receive feedback, obtain recipes and
be part of a discussion board if they chose. The
study has not completed yet. Linear mixed models
were used to estimate least square means of lipids
according to quartiles of the DII.
Only baseline data was used for this analysis.
It is hypothesized that once the study concludes
the data will show a decrease in inflammation
levels for the participants. This shows that
interventions with emphasis on a diet change
similar to vegan or vegetarian has potential to
positively decrease inflammation levels but are
not the only anti-inflammatory dietary patterns.
Based on this analysis, it could suggest that the
DII may not be a predictor of lipid levels in this
population at baseline only. However, data is
continuing to be collected and future analyses
will confirm whether the DII is associated with
changes in lipids and inflammation after a
healthy lifestyle intervention.
Objective
The overall objective of IMAGINE is to reduce
inflammation through an anti-inflammatory
diet, as measured by the DII, physical activity,
and stress reduction intervention. Considering
IMAGINE is still ongoing, the objective of this
specific project was to determine if the DII was
associated with baseline lipid levels. As shown in Table 1, males, particularly
participants younger in age, were more likely to
have a greater pro-inflammatory diet compared
to females. Caucasians tended to have a more
anti-inflammatory diet compared to African
Americans or those of other races. In Table 2,
many of the comparisons did not achieve
statistical significance most likely because of the
small sample size. There was no significant
difference in lipid levels between the DII
quartiles.
Acknowledgements
Thank you to Nicole Wodzinski, the Douglass
Project and the Douglass Alumni for funding and
supporting me to participate in a research
opportunity this summer. I would also like to
thank the entire faculty at the University of South
Carolina Cancer Prevention and Control
Program, especially my advisor, Dr. Michael
Wirth, for the opportunity to be a part of the
IMAGINE study this summer.
References
Shivappa, N., Steck, S. E., Hurley, T. G., Hussey,
J.
R., & Hébert, J. R. (2014). Designing and
developing a literature-derived, population-
based dietary inflammatory index. Public
Health Nutrition, 17(8), 1689–1696.
http://doi.org/10.1017/
S1368980013002115.
IMAGINE Study Application funded as a Small
Business Innovation Research Grant to Drs.
Michael Wirth and Nitin Shivappa, 2015.
Table 1: Main Variables According to Quartiles of the Dietary Inflammatory Index
Characteristic
Entire
Population
(n=93)
Q1 Q2 Q3 Q4 P-Value
Sex           0.42
Male 18 (19%) 2 (9%) 6 (27%) 4 (17%) 5 (23%)  
Female 75 (81%) 21 (91%) 16 (73%) 19 (83%) 17 (77%)  
Race           0.47
African American and Other 35 (38%) 9 (39%) 6 (27%) 8 (35%) 11 (50%)  
White 58 (62%) 14 (61%) 16 (73%) 15 (65%) 11 (50%)  
Education Level           0.34
High school completed with
some college
25 (27%) 9 (39%) 6 (27%) 5 (22%) 5 (23%)  
College completed 36 (39%) 9 (39%) 6 (27%) 12 (52%) 7 (32%)  
More than college completed 32 (34%) 5 (22%) 10 (45%) 6 (26%) 10 (45%)  
Marital Status           0.82
Married/ Living with Partner 54 (58%) 16 (70%) 13 (59%) 11 (48%) 13 (59%)  
Separated/ Widowed/
Divorced
18 (19%) 4 (17%) 4 (18%) 5 (22%) 5 (23%)  
Never Married 21 (23%) 3 (13%) 5 (23%) 7 (30%) 4 (18%)  
Smoking Status           0.27
Never 66 (71%) 14 (61%) 17 (77%) 14 (61%) 18 (82%)  
Former or current 27 (29%) 9 (39%) 5 (23%) 9 (39%) 4 (18%)  
CESD Score           0.26
< 16 82 (88%) 22 (96%) 21 (95%) 19 (83%) 18 (82%)  
>= 16 11 (12%) 1 (4%) 1 (5%) 4 (17%) 4 (18%)  
Continuous Measures Mean (SD)  P-Value
Age (y) 46.8 (14.3) 53.0 (12.6) 46.0 (14.4) 48.5 (12.5) 38.9 (14.9) < 0.05
BMI (kg/m2
) 31.2 (7.1) 30.5 (6.1) 30.5 (5.1) 33.3 (7.7) 30.4 (9.3) 0.96
Table 2: Adjusted Mean Lipid Values by Dietary Inflammatory Index Quartiles
Lipids
DII
Q1 Q2 Q3 Q4 P-Value
TC (mg/dL) 189.5 (167.9) 188.9 (168.4) 183.1 (163.5) 183.5 (161.9) 0.66
Trigs (mg/dL) 214.1 (98.7) 110.0 (-0.04) 134.7 (29.4) 137.2 (21.4) 0.29
HDL (mg/dL) 51.9 (45.0) 56.3 (49.7) 53.1 (46.8) 52.5 (45.5) 0.90
LDL (mg/dL) 102.9 (84.8) 110.0 (93.1) 104.8 (88.1) 105.9 (88.0) 0.80

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IMAGINE Research Poser_TL_2016

  • 1. The Inflammation Management Intervention: Associations between the Dietary Inflammatory Index and Baseline Lipids Taylor Lamia, Dr. Michael Wirth South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina Introduction Methods Results Conclusions An increasing amount of evidence links chronic inflammation to nearly all chronic diseases with diet being a strong modulator of chronic, systemic inflammation. In order to analyze one’s inflammatory potential, epidemiologists at the University of South Carolina created the Dietary Inflammatory Index (DII)TM . “The goal in creating the original DII in 2009 was to provide a tool that could categorize individual’s diets on a continuum from maximally anti-inflammatory to maximally pro-inflammatory” (Shivappa, et al. 2014). It was hypothesized that higher (i.e., more pro-inflammatory) baseline DII scores will be associated with higher lipid levels (total cholesterol, triglycerides, high [HDL] and low [LDL] density lipoprotein) compared to those with lower (i.e., more anti-inflammatory) DII scores. Study Population To assess reduction in inflammation using the DII and other health behaviors of middle-aged adults who are at risk for chronic disease, the University of South Carolina Cancer Prevention and Control Program developed an inflammation management intervention study that is a currently ongoing, non-randomized, two- arm intervention study of 93 individuals (34 control; 59 intervention). The intervention is a combination of efforts to reduce chronic inflammation levels:  DII-based nutrition modifications  Physical activity management  Stress management The intervention met weekly for 12 weeks and monthly for the remaining 9 months. After the 12-week mark, participants are given access to the web application where they are able to track dietary information, receive feedback, obtain recipes and be part of a discussion board if they chose. The study has not completed yet. Linear mixed models were used to estimate least square means of lipids according to quartiles of the DII. Only baseline data was used for this analysis. It is hypothesized that once the study concludes the data will show a decrease in inflammation levels for the participants. This shows that interventions with emphasis on a diet change similar to vegan or vegetarian has potential to positively decrease inflammation levels but are not the only anti-inflammatory dietary patterns. Based on this analysis, it could suggest that the DII may not be a predictor of lipid levels in this population at baseline only. However, data is continuing to be collected and future analyses will confirm whether the DII is associated with changes in lipids and inflammation after a healthy lifestyle intervention. Objective The overall objective of IMAGINE is to reduce inflammation through an anti-inflammatory diet, as measured by the DII, physical activity, and stress reduction intervention. Considering IMAGINE is still ongoing, the objective of this specific project was to determine if the DII was associated with baseline lipid levels. As shown in Table 1, males, particularly participants younger in age, were more likely to have a greater pro-inflammatory diet compared to females. Caucasians tended to have a more anti-inflammatory diet compared to African Americans or those of other races. In Table 2, many of the comparisons did not achieve statistical significance most likely because of the small sample size. There was no significant difference in lipid levels between the DII quartiles. Acknowledgements Thank you to Nicole Wodzinski, the Douglass Project and the Douglass Alumni for funding and supporting me to participate in a research opportunity this summer. I would also like to thank the entire faculty at the University of South Carolina Cancer Prevention and Control Program, especially my advisor, Dr. Michael Wirth, for the opportunity to be a part of the IMAGINE study this summer. References Shivappa, N., Steck, S. E., Hurley, T. G., Hussey, J. R., & Hébert, J. R. (2014). Designing and developing a literature-derived, population- based dietary inflammatory index. Public Health Nutrition, 17(8), 1689–1696. http://doi.org/10.1017/ S1368980013002115. IMAGINE Study Application funded as a Small Business Innovation Research Grant to Drs. Michael Wirth and Nitin Shivappa, 2015. Table 1: Main Variables According to Quartiles of the Dietary Inflammatory Index Characteristic Entire Population (n=93) Q1 Q2 Q3 Q4 P-Value Sex           0.42 Male 18 (19%) 2 (9%) 6 (27%) 4 (17%) 5 (23%)   Female 75 (81%) 21 (91%) 16 (73%) 19 (83%) 17 (77%)   Race           0.47 African American and Other 35 (38%) 9 (39%) 6 (27%) 8 (35%) 11 (50%)   White 58 (62%) 14 (61%) 16 (73%) 15 (65%) 11 (50%)   Education Level           0.34 High school completed with some college 25 (27%) 9 (39%) 6 (27%) 5 (22%) 5 (23%)   College completed 36 (39%) 9 (39%) 6 (27%) 12 (52%) 7 (32%)   More than college completed 32 (34%) 5 (22%) 10 (45%) 6 (26%) 10 (45%)   Marital Status           0.82 Married/ Living with Partner 54 (58%) 16 (70%) 13 (59%) 11 (48%) 13 (59%)   Separated/ Widowed/ Divorced 18 (19%) 4 (17%) 4 (18%) 5 (22%) 5 (23%)   Never Married 21 (23%) 3 (13%) 5 (23%) 7 (30%) 4 (18%)   Smoking Status           0.27 Never 66 (71%) 14 (61%) 17 (77%) 14 (61%) 18 (82%)   Former or current 27 (29%) 9 (39%) 5 (23%) 9 (39%) 4 (18%)   CESD Score           0.26 < 16 82 (88%) 22 (96%) 21 (95%) 19 (83%) 18 (82%)   >= 16 11 (12%) 1 (4%) 1 (5%) 4 (17%) 4 (18%)   Continuous Measures Mean (SD)  P-Value Age (y) 46.8 (14.3) 53.0 (12.6) 46.0 (14.4) 48.5 (12.5) 38.9 (14.9) < 0.05 BMI (kg/m2 ) 31.2 (7.1) 30.5 (6.1) 30.5 (5.1) 33.3 (7.7) 30.4 (9.3) 0.96 Table 2: Adjusted Mean Lipid Values by Dietary Inflammatory Index Quartiles Lipids DII Q1 Q2 Q3 Q4 P-Value TC (mg/dL) 189.5 (167.9) 188.9 (168.4) 183.1 (163.5) 183.5 (161.9) 0.66 Trigs (mg/dL) 214.1 (98.7) 110.0 (-0.04) 134.7 (29.4) 137.2 (21.4) 0.29 HDL (mg/dL) 51.9 (45.0) 56.3 (49.7) 53.1 (46.8) 52.5 (45.5) 0.90 LDL (mg/dL) 102.9 (84.8) 110.0 (93.1) 104.8 (88.1) 105.9 (88.0) 0.80