This paper presents a technique for identifying influential Twitter users who can help spread information about combating disease epidemics like Zika. An offline model is trained on labeled tweets to classify relevant tweets. An online system then ranks Twitter users based on metrics like topic focus and overall focus that measure how many of a user's tweets are relevant. The top ranked users may be engaged to help increase the effectiveness of health campaigns by leveraging real-time social media streams. Preliminary results found some success in identifying influential users but also limitations of using only topological metrics like TwitterRank.