Assessment of the “Mode of Action Landscape” for particular disease areas is of high interest for pharmaceutical companies. To enable identification of upcoming, established and vanishing modes of action over time and clinical phases it is crucial to have tools for integration and comparison of drug pipeline data from various sources, including informative visualizations of changes in the landscape. The BizInt Smart Charts product family including VantagePoint - Smart Charts Edition (VP-SCE) enables these analyses and was therefore selected for evaluation. Data was integrated from different key drug pipeline databases, and the newly developed VP-SCE provided opportunities to use in-house data for normalization of important field content such as the highly diverse lists of “Mode of Action” generated by the pipeline databases. Using an example of pipeline data in the field of breast cancer we will show how the data was curated and processed to reach the final landscape, and how the programs can be applied in the most effective way. Examples of visualizations for facilitated decision-making will also be shown. To this end, our presentation will provide insight on the value of integrating and visualizing both external and internal data from drug pipelines employing these tools.

1. Tracking of the Mode of Action Landscape in
Breast Cancer using Report and Visualization
Tools
Karen Jendro & Rebecca Ceder
ICIC 2014, Heidelberg, Germany - October 14, 2014
Roche Pharma Research and Early Development, Roche Innovation Center Basel
Roche Diagnostics GmbH, Penzberg

2. The Information Science Group in Penzberg
Duties and Responsibilities
Main duty
Performing searches
Patent
searches
Literature
searches
Sequence
searches
Business
searches
Enduser-
Support for
search tools
Consultancy
Information
workflow
Database
development
Evaluation
of new
sources and
tools
Support with
text mining
approaches
= Karen‘s Job

3. The Data Science Group in Basel
Duties and Responsibilities
Main Activities
Searching/Analyzing
Imaging
Literature
Competitor NGS data
Information
Networks and
Pathways
Support
Data
Integration
Target
identification/
assessment
Evaluation
of new
sources and
tools
Text-mining
= Rebecca‘s job

4. Competitor Information @Roche
Competitor Information: Our Definition
 Competitor Information (CI) comprises secondary market research
and pipeline data sources (=published public domain information)
that are utilized to generate competitor landscapes (=overviews),
to enhance the analysis of Roche’s activities, and thus to facilitate
fact-based decision making regarding our drug pipeline portfolio.
 CI is an important part of the whole Competitive Intelligence
process at Roche

5. Competitor Information @Roche
Background

6. Competitor Information @Roche
Background

7. The Goal
We want to create a visualization of the
competitor information landscape that displays
changes in the Mode of Action over time
normalize
visualize
analyze
changes

8. Major Questions to Address
1. How can we normalize the Mode of Action
across different databases/information
sources?
2. How can we visualize the Mode of Action
Landscape in one figure to provide an
overview?
3. How can we analyze and visualize the
changes in the Mode of Action Landscape
in a decision-making figure?

9. Import of the Breast Cancer Competitor
Information Landscape into BizInt Smart
Charts
• The competitor information landscape from CIAP for Breast Cancer contains
4478 records from 3 different databases
We want to normalize the “Mode of Action”

10. Normalization of the “Mode of Action”
– Using VantagePoint-Smart Charts Edition
Display of the “Mode of Action” Normalization of the “Mode of Actions
using the Vantage-Point “Clean up”
Function
This process is partly automated,
still requires manual “clean-up”

11. Normalization of the Mode of Action –
- Using the Roche Terminology Service
272 records in total
This process is fully automated

12. A bubble chart
can be produced
to overview the
normalized
Mode of Action
Landscape
Using Vantage
Point-SCE
Visualization of the Mode of Action Landscape
- An Overview

13. Bubble
Chart, Data
from June
2014
Bubble
Chart, Data
from
August
Differences 2014
/Changes
are hard to
identify!
Visualization of the Mode of Action Landscape
-How Can We Determine the Changes?

14. Step 1: Data generation
- BizInt Reference Rows
• Essential: to have a function
which compares the Modes of
Action of each Substance, found
in the Pipeline Databases =>
Usage of „Compare Columns“ in
Reference Rows
• Important: to get the additional
as well as the vanished MoAs
MoAs
Substance
1
MoAs
Substance
2

15. Step 2: Further processing in Visualization
Tool
• Import to Vantage Point-SCE
• Selection of data to be visualized
• Usage of Scipt for creation of
bubble chart

16. Step 3: Result = Integrated Bubble Chart
• Colors indicating increase,
decrease, no change and
both directions
• Numbers indicating the
count of Substances and
arrows the direction of
change

17. Complementary Examples where Data
Comparison
Approaches Can Play a Key Role
• Tracking of geographical distribution of clinical trials
over time
- by comparing Countries by Trial Phase
• Visualization of the shift towards new Indications for
Drug classes, Drugs
- by comparing Indications by Trial Phase
• Change of Licensing availabilities for Drugs in
certain indications
- by comparing the Countries a license is available
in
• Identification of new modes of action a company is
working on
- by comparing MoAs by Trial Phase
• And a lot of more ....

18. Summary
And Take Home Messages
• Most important: you need to have the appropriate
thesaurus to clean up your data to get the most
value out of it
• The key to success was the “compare column”
function in BizInt Reference Rows combined with
the newly added Script for creating the “integrated
bubble chart”
• Not to forget: having fun with developing new ways
to deal with data together with brilliant heads inside
and outside of Roche!

19. Acknowledgements
In alphabetical order
• Dr Markus Bundschus (Roche)
• Matt Eberle (BizInt)
• Dr Barbara Endler-Jobst (Roche)
• Dr Werner Klaus (Roche)
• Dr Pascal Kuner (Roche)
• Dr Martin Romacker (Roche)
• Diane Webb (BizInt)
• John Willmore (BizInt)
• VantagePoint Smart Charts Edition

20. Doing now what patients need next