Ibuprofen Presentation.pptx
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Brufen is a non-selective COX inhibitor that provides relief from pain, inflammation, and fever by inhibiting prostaglandin production. It is indicated for these conditions and contraindicated in those with hypersensitivity or severe liver, heart, or kidney issues. Brufen is rapidly absorbed and metabolized by the liver, with a half-life of around 2 hours. Dosing is based on age and weight. Compared to paracetamol, Brufen has a faster onset of action, greater fever reduction, and longer duration due to its anti-inflammatory effects.
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Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
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These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
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Ibuprofen Presentation.pptx
- 1. BRUFEN IBUPROFEN ـَمْحَّالر ِهـَّالل ِمْسِب ي ِحَّالر ِن م
- 2. TOPICS • Introduction of Pain, Inflammation and Fever • Pharmacology (Mechanism of Action of Brufen) • Indications and Contraindications of Brufen • Pharmacokinetics • Pharmacodynamics (Dose) • Brufen vs Paracetamol
- 3. PAIN AND INFLAMMATION • Pain is an unpleasant sensory and emotional experience associated with actual and potential tissue damage, and described in terms of such damage. • Inflammation is a natural biological response produced by the tissues within our body as a reaction to the harmful stimuli in order to eradicate the necrotic cells and initiate the tissue repairing process • The normal physiological perception of pain is known as nociception. Injury Transduction Transmission Perception Modulation
- 4. MECHANISM OF PAIN Phospholipase Lipoxygenase COX-I COX-II Cycloxygenase Prostaglandin s associated with: • GI mucosal integrity • Platelets function • Renal function Prostaglandins associated with: • Pain • Inflammation • Fever Damaged Cell membrane Arachidonic Acid Leukotrienes such as: Substance-P
- 5. TYPES OF PAIN Acute Pain Chronic Pain Short-term, often self- limiting. Lasts months or years. Sympathetic nervous system activity e.g. elevated pulse and blood pressure. Physiological adaptation e.g. normal pulse and blood pressure. Responsive to standard treatments. Unresponsive to standard treatment. For example: Dental pain, Lower back pain, Headache For example: Cancer pain, Rheumatoid arthritis, Osteoarthritis
- 6. FEVER • Fever is an increase in body temperature resulting from infection or inflammation. • Normally body temperature is maintained by hypothalamus at about 37°C (98.6°F). • In case of microbial infection certain white blood cells release a chemical known as endogenous pyrogen. • Endogenous pyrogen raises the set point of the thermostat and the hypothalamus maintains temperature at a new higher level. • Endogenous pyrogen raises the set point during fever by triggering the release of prostaglandins. These act directly on the hypothalamus.
- 7. ROLE OF PROSTAGLANDINS IN FEVER Infection / Inflammation WBCs Endogenous pyrogens Prostaglandins Raise Set point in Hypothalamus Heat Production & Heat Loss Fever Note NSAIDs reduce fever by inhibiting the production of prostaglandins. They have no effect on normal body temperature because prostaglandins are produced only in the presence of endogenous pyrogen.
- 8. MECHANISM OF BRUFEN Phospholipase Lipoxygenase COX-I COX-II Cycloxygenase Prostaglandin s associated with: • GI mucosal integrity • Platelets function • Renal function Prostaglandins associated with: • Pain • Inflammation • Fever Damaged Cell membrane Arachidonic Acid Leukotrienes such as: Substance-P Brufen Brufen Brufen is Non-selective Cycloxygenase (COX) inhibitor.
- 9. INDICATIONS: Brufen has three principal pharmacological actions. • Anti-inflammatory • Antipyretic • Analgesic. CONTRAINDICATIONS: • Known Hypersensitivity to Ibuprofen. • Patients who have experienced asthma, urticaria or allergic type reactions after taking aspirin or other NSAIDs. • Patients with severe heart failure, liver failure and Renal failure.
- 10. PHARMACOKINETICS • Absorption: Brufen is rapidly absorbed following oral administration and peak serum levels are achieved within 1-2 hours. Bioavailability is 80-100%. • Distribution: Protein binding of Brufen is >90% and concentration >20 mcg/mL • Metabolism: Brufen is metabolised in Liver into inactive metabolites. • Elimination: Half Life approx. 2 hours, eliminated mainly through urine.
- 11. PHARMACODYNAMICS Age Dose Frequency 3 to 6 months (weight >5 kg) 5 mg/kg 3 times a day 6 months to 1 year 2.5 ml (50 mg) of Brufen suspension 3 times a day 1 to 2 years 2.5 ml (50 mg) of Brufen suspension 3 to 4 times a day 3 to 7 years 5 ml(100 mg) of Brufen suspension OR 2.5 ml (100 mg) of Brufen DS 3 to 4 times a day
- 12. BRUFEN VS PARACETAMOL • Brufen provides Rapid onset of action as compare to acetaminophen. • Brufen provides greater degree of fever reduction as compare to paracetamol • Brufen provides longer duration of action as compare to paracetamol. • Brufen has anti-inflammatory effect while paracetamol not. • Brufen is available in delicious orange flavour. BRUFEN®Syrup produces significantly greater fever reduction than paracetamol syrup 4 hours after the first dose.
- 13. IBUPROFEN PRODUCES A MORE RAPID AND A GREATER AND LONGER ANTIPYRETIC EFFECT THAN PARACETAMOL
- 14. BRUFEN SYRUP PRODUCES GREATER FEVER CONTROL THAN PARACETAMOL SYRUP IN CHILDREN (SINGLE DOSE)