The document presents the findings of the EHR Impact (EHRI) study, which evaluates the socio-economic benefits of interoperable electronic health record and e-prescription systems across various case studies in Europe and the USA. The results indicate substantial economic value generated, with cumulative benefits significantly exceeding costs, though the investment yields differing returns across stakeholder groups. Key insights emphasize the importance of usability, the role of organizational readiness, and the necessity for interoperability in achieving effective health information systems.