Hypertension is an ailment characterized by elevated blood pressure that can cause disorders of the cardiovascular and renal systems. The primary purpose of management is to regulate blood pressure and diminish the risk of cardiovascular diseases. Cardiac output and peripheral resistance may be reduced to lower blood pressure. Diuretics, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), and medicines targeting the sympathetic nervous system are the most often prescribed medications in this protocol (Sear, 2019). Diuretics with natriuretic activity are among the most often prescribed medications globally. For example, they work by decreasing salt reabsorption at various points in a kidney and increasing sodium and water excretion. There is another group of diuretics, referred to as aquaretics, works by inhibiting vasopressin receptors in the connecting duct and collecting tube, preventing the body from reabsorbing water (Sear, 2019). Beta-blockers such as catecholamines, epinephrine, and norepinephrine bind to B1 receptors in the heart, increasing cardiac automaticity and conduction speed. Renin release is also induced by B1 receptors, which raises blood pressure (Sear, 2019). In contrast, binding to B2 receptors results in smooth muscle relaxation and metabolic consequences such as glycogenolysis in the body. Beta-blockers also lower blood pressure through decreasing renin and decreasing cardiac output, among other methods. Blood pressure and pulse rate go up when alpha-1 receptors become overactive, which happens when there is a severe reaction to the receptors signaling. Blood pressure and heart rate fall due to negative chronotropic effects caused by antagonistic interactions at the alpha-1 receptor (Sear, 2019).  Like beta-blockers, ARBs are antihypertensive drugs, but their mode of action is different by blocking the hormone Angiotensin II. Contrast this with angiotensin II inhibitors, which prevent the body from manufacturing an enzyme that produces angiotensin II, narrowing blood arteries. High blood pressure and an increased workload on the heart might result from narrowing the arteries. Blood pressure-raising hormones are also released by angiotensin II. The L-type "long-acting" voltage-gated calcium channels in the pancreas, smooth muscle, and heart are blocked by calcium channel antagonists (Sear, 2019). Because of their inhibitory actions on the sinoatrial and atrioventricular nodes, the non-dihydropyridines reduce cardiac conduction and contractility more than dihydropyridines. In this way, hypertension may be treated, oxygen demand can be reduced, and tachydysrhythmia rates can be controlled more easily (Sear, 2019). Conduction velocity increases and cardiac automaticity improves by B1 receptor-binding catecholamines such as adrenaline and norepinephrine. Renin release is also induced by B1 receptors, which raises blood pressure.        The nurse ...

1. Hypertension is an ailment characterized by elevated blood
pressure that can cause disorders of the cardiovascular and renal
systems. The primary purpose of management is to regulate
blood pressure and diminish the risk of cardiovascular diseases.
Cardiac output and peripheral resistance may be reduced to
lower blood pressure. Diuretics, beta-blockers, angiotensin-
converting enzyme (ACE) inhibitors, angiotensin receptor
blockers (ARBs), calcium channel blockers (CCBs), and
medicines targeting the sympathetic nervous system are the
most often prescribed medications in this protocol (Sear, 2019).
Diuretics with natriuretic activity are among the most often
prescribed medications globally. For example, they work by
decreasing salt reabsorption at various points in a kidney and
increasing sodium and water excretion.
There is another group of diuretics, referred to as aquaretics,
works by inhibiting vasopressin receptors in the connecting duct
and collecting tube, preventing the body from reabsorbing water
(Sear, 2019). Beta-blockers such as catecholamines,
epinephrine, and norepinephrine bind to B1 receptors in the
heart, increasing cardiac automaticity and conduction speed.
Renin release is also induced by B1 receptors, which raises
blood pressure (Sear, 2019). In contrast, binding to B2 receptors
results in smooth muscle relaxation and metabolic consequences
such as glycogenolysis in the body. Beta-blockers also lower
blood pressure through decreasing renin and decreasing cardiac
output, among other methods. Blood pressure and pulse rate go
up when alpha-1 receptors become overactive, which happens
when there is a severe reaction to the receptors signaling. Blood
pressure and heart rate fall due to negative chronotropic effects
caused by antagonistic interactions at the alpha-1 receptor
(Sear, 2019).
Like beta-blockers, ARBs are antihypertensive drugs, but their
mode of action is different by blocking the hormone
Angiotensin II. Contrast this with angiotensin II inhibitors,

2. which prevent the body from manufacturing an enzyme that
produces angiotensin II, narrowing blood arteries. High blood
pressure and an increased workload on the heart might result
from narrowing the arteries. Blood pressure-raising hormones
are also released by angiotensin II. The L-type "long-acting"
voltage-gated calcium channels in the pancreas, smooth muscle,
and heart are blocked by calcium channel antagonists (Sear,
2019). Because of their inhibitory actions on the sinoatrial and
atrioventricular nodes, the non-dihydropyridines reduce cardiac
conduction and contractility more than dihydropyridines. In this
way, hypertension may be treated, oxygen demand can be
reduced, and tachydysrhythmia rates can be controlled more
easily (Sear, 2019). Conduction velocity increases and cardiac
automaticity improves by B1 receptor-binding catecholamines
such as adrenaline and norepinephrine. Renin release is also
induced by B1 receptors, which raises blood pressure.
The nurse must advise the patient that diuretics should be
given in the morning to prevent nocturnal diuresis and frequent
nocturnal urination. To minimize rebound tachycardia and
hypertension, the patient should be informed that their
prescriptions must be continued (Benetos et al., 2019). If a
patient has adverse effects, the nurse or physician should report
them. Patients should report dizziness and other manifestations
of an irregular heartbeat. Furthermore, the patient should be
informed on medication compliance, increase in weight, and
blood pressure monitoring at home. Patients should adhere to
their medication regimen and take their medicine
simultaneously each day. Within 24 hours, they should avoid
taking more than the authorized amount (Benetos et al., 2019).
On the other hand, medications might lead to dry mouth and
eyes. While using these drugs, individuals should abstain from
alcoholic beverages and other CNS depressants (Benetos et al.,
2019).
References
Benetos, A., Petrovic, M., & Strandberg, T. (2019).

3. Hypertension management in older and frail older
patients. Circulation Research, 124(7), 1045-1060.
https://doi.org/10.1161/CIRCRESAHA.118.313236
Sear, J. W. (2019). Antihypertensive drugs and vasodilators.
In Pharmacology and Physiology for Anesthesia (pp. 535-555).
Elsevier. https://doi.org/10.1016/B978-0-323-48110-6.00026-0