Hyper-IgM syndrome is a rare genetic disease caused by a loss-of-function mutation in the gene that codes for the CD40L protein. What are the two most likely direct effects of CD40L deficiency? (Select two answers.) Increased recruitment of neutrophils into inflamed tissue. Reduced recruitment of neutrophils into inflamed tissue. Reduced phagocytic function of macrophages. correct A failure of the germinal center reaction. correct A loss of IFN- function. Correct Answer is: Reduced phagocytic function of macrophages. and A failure of the germinal center reaction..