Verne Harnish outlines key strategies for upscaling a business through his 4D framework: Drivers emphasize leadership in staff development, Demands focus on balancing stakeholder needs with product quality, Discipline encourages creating achievable quarterly goals, and Decisions involve regular risk management to prioritize issues. Effective scaling requires a clear brand promise, a long-term 'big hairy audacious goal' (BHAG), and an up-to-date one-page strategic plan (OPSP). Businesses must also enhance financial reserves, optimize the cash conversion cycle, and maintain open communication to support their strategic vision.