How SNRIs Work
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This video explains how SNRIs (serotonin norepinephrine reuptake inhibitors) work. Brought to you by AnxietyBoss.com and Dr. Carlo Carandang, MD.
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Ssri n snri
SSRIs and SNRIs are commonly used to treat depression. SSRIs work by blocking the reuptake of serotonin, increasing levels of the neurotransmitter in the brain. Common SSRIs include fluoxetine, paroxetine, sertraline, and citalopram. SNRIs like venlafaxine also block the reuptake of serotonin and norepinephrine. These drugs are generally well-tolerated but side effects may include nausea, insomnia, sexual dysfunction, and agitation. Guidelines recommend SSRIs as first-line treatment for moderate to severe depression.
SSRIs
The document compares the serotonergic antidepressants currently available in the US on variables such as indications, efficacy, structure, pharmacodynamics, pharmacokinetics, side effects, dosing preparations, and cost considerations. It discusses that while the drugs are structurally unrelated, they all inhibit neuronal reuptake of serotonin. Their potency and selectivity at the serotonin transporter varies, which may account for some differences seen between individual patient responses. Overall, all drugs are considered similarly effective compared to placebo and TCAs for treating conditions like depression and anxiety.
Selective serotonin reuptake inhibitors 2016
Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that work by inhibiting the reuptake of serotonin. SSRIs include fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, and escitalopram. They are highly selective for serotonin reuptake compared to other neurotransmitters. While SSRIs share the common mechanism of inhibiting serotonin reuptake, they differ in their pharmacokinetic properties such as half-life, metabolic pathways, and drug interaction potential. Adverse effects of SSRIs include nausea, sexual dysfunction, headaches, and weight changes.
ANTIDEPRESSANTS
This document provides an overview of antidepressant drugs. It discusses the criteria for major depression and epidemiology. It then covers the pharmacology of different classes of antidepressants including SSRIs, SNRIs, serotonin receptor antagonists, bupropion, and MAOIs. For each class, it discusses mechanisms of action, pharmacokinetics, uses, adverse effects, and drug interactions.
Ssri.ppt 2013
SSRIs are a class of antidepressant drugs that work by inhibiting the reuptake of serotonin in the brain. They are commonly used to treat depression but also anxiety, OCD, and other disorders. While SSRIs take weeks to have an effect due to their mechanism of action beyond just increasing serotonin levels, they have fewer side effects than older antidepressants. Common side effects include nausea, sexual dysfunction, insomnia, and headaches. Drug interactions can occur and serotonin syndrome is a potential risk. SSRIs are generally preferred over older antidepressants due to their safety profile.
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*Learn neurobiology of psychosis
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*Learn treatment of psychosis in youth
Metyrosine and Psychosis
Metyrosine has shown promise in treating psychosis associated with Velocardiofacial Syndrome (VCFS). A case report described a 15-year-old male with VCFS and treatment-resistant psychosis. He was unresponsive to multiple antipsychotics. Treatment with metyrosine led to a reduction in neuropsychiatric symptoms. Metyrosine inhibits the enzyme tyrosine hydroxylase, reducing dopamine levels and psychotic symptoms. This case provides preliminary evidence that metyrosine may effectively treat psychosis in VCFS patients where other treatments have failed.
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*Learn about prevalence and treatment interventions for refractory depression in adolescents
*Summarize the intervention studies in refractory mood disorders in adolescents
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Ssri n snri
SSRIs and SNRIs are commonly used to treat depression. SSRIs work by blocking the reuptake of serotonin, increasing levels of the neurotransmitter in the brain. Common SSRIs include fluoxetine, paroxetine, sertraline, and citalopram. SNRIs like venlafaxine also block the reuptake of serotonin and norepinephrine. These drugs are generally well-tolerated but side effects may include nausea, insomnia, sexual dysfunction, and agitation. Guidelines recommend SSRIs as first-line treatment for moderate to severe depression.
SSRIs
The document compares the serotonergic antidepressants currently available in the US on variables such as indications, efficacy, structure, pharmacodynamics, pharmacokinetics, side effects, dosing preparations, and cost considerations. It discusses that while the drugs are structurally unrelated, they all inhibit neuronal reuptake of serotonin. Their potency and selectivity at the serotonin transporter varies, which may account for some differences seen between individual patient responses. Overall, all drugs are considered similarly effective compared to placebo and TCAs for treating conditions like depression and anxiety.
Selective serotonin reuptake inhibitors 2016
Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that work by inhibiting the reuptake of serotonin. SSRIs include fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, and escitalopram. They are highly selective for serotonin reuptake compared to other neurotransmitters. While SSRIs share the common mechanism of inhibiting serotonin reuptake, they differ in their pharmacokinetic properties such as half-life, metabolic pathways, and drug interaction potential. Adverse effects of SSRIs include nausea, sexual dysfunction, headaches, and weight changes.
ANTIDEPRESSANTS
This document provides an overview of antidepressant drugs. It discusses the criteria for major depression and epidemiology. It then covers the pharmacology of different classes of antidepressants including SSRIs, SNRIs, serotonin receptor antagonists, bupropion, and MAOIs. For each class, it discusses mechanisms of action, pharmacokinetics, uses, adverse effects, and drug interactions.
Ssri.ppt 2013
SSRIs are a class of antidepressant drugs that work by inhibiting the reuptake of serotonin in the brain. They are commonly used to treat depression but also anxiety, OCD, and other disorders. While SSRIs take weeks to have an effect due to their mechanism of action beyond just increasing serotonin levels, they have fewer side effects than older antidepressants. Common side effects include nausea, sexual dysfunction, insomnia, and headaches. Drug interactions can occur and serotonin syndrome is a potential risk. SSRIs are generally preferred over older antidepressants due to their safety profile.
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*Learn clinical assessment of psychosis in youth
*Learn neurobiology of psychosis
*Learn course and prognosis of psychosis
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Metyrosine has shown promise in treating psychosis associated with Velocardiofacial Syndrome (VCFS). A case report described a 15-year-old male with VCFS and treatment-resistant psychosis. He was unresponsive to multiple antipsychotics. Treatment with metyrosine led to a reduction in neuropsychiatric symptoms. Metyrosine inhibits the enzyme tyrosine hydroxylase, reducing dopamine levels and psychotic symptoms. This case provides preliminary evidence that metyrosine may effectively treat psychosis in VCFS patients where other treatments have failed.
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“Lamotrigine for Treatment Refractory Mood Disorders in Adolescents: A Case Series,”
Halifax, Nova Scotia, Canada; September 14, 2005
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*Learn about prevalence and treatment interventions for refractory depression in adolescents
*Summarize the intervention studies in refractory mood disorders in adolescents
*Dissect the 9 cases of lamotrigine for treatment refractory mood disorders in adolescents
*Learn pharmacokinetics and pharmacodynamics of lamotrigine
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*Although the core symptoms of depression are similar across the life span, developmental differences exist and should be taken into account in the assessment
*With increasing age, there generally is an increase in melancholic symptoms, delusions, substance abuse, and suicidal ideation/attempts.
*In contrast, younger children tend to have more somatic sxs, separation anxiety, behavior problems, temper tantrums, and hallucinations
*Direct interviews with children and adolescents are critical because parents and teachers may not be aware of the youth’s depressive symptoms
*Discrepant information between parents and their children should be solve in a cordial and non judgmental way
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