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Open Source Pharma: Crowd computing: A new approach to predictive modelingOpen Source Pharma
Presentation about "Predictive in silico models," given by Joerg Bentzien at the Open Source Pharma Conference. The event took place at Rockefeller Foundation Bellagio Center in July 2014.
Joerg Bentzien Bio:
http://www.opensourcepharma.net/participants/jorg-bentzien
Conference Agenda (see Day 1, Session 2):
http://www.opensourcepharma.net/agenda.html
Open Source Pharma: Crowd computing: A new approach to predictive modelingOpen Source Pharma
Presentation about "Predictive in silico models," given by Joerg Bentzien at the Open Source Pharma Conference. The event took place at Rockefeller Foundation Bellagio Center in July 2014.
Joerg Bentzien Bio:
http://www.opensourcepharma.net/participants/jorg-bentzien
Conference Agenda (see Day 1, Session 2):
http://www.opensourcepharma.net/agenda.html
0 A Work Project, presented as part of the requireme.docxoswald1horne84988
0
A Work Project, presented as part of the requirements for the Award of a Masters
Degree in Management from the Nova School of Business and Economics
Illumina:
The sustainability of its competitive position
Marta Gonçalves Serra #1467
A project carried out on the Strategy course, under the supervision of
Professor Luís Almeida Costa
December 2014
1
Acknowledgements
I would like to sincerely thank my supervisor, Professor Luís Almeida Costa, for his
patient guidance, availability and advice he has given me throughout the course of this
project. His mentorship was essential for the success of this work and ultimately, for my
overall and round learning. I would also like to thank Stathis Kanterakis, member of the
Bioinformatics team at Illumina (Cambridge, United Kingdom) for all the information he
shared with me regarding Illumina and the Sequencing Market. He also made possible the
opportunity to visit Illumina’s site at Cambridge and to directly meet employees. All his
contributions were essential to get a greater insight of the company. Additionally, I would
also like to thank my sister, Eva Serra, currently a PhD student at Cambridge and the
Wellcome Trust Sanger Institute, for her continued support in terms of scientific and
technical understanding of the human genome area.
2
Introduction
This work project presents a case study about the sustainability of the competitive position of
Illumina in the Sequencing Market. This is a very recent market, which is growing at
unexpected rates and is contributing for many scientific discoveries. Illumina is currently the
market leader in the sequencing devices manufacturing business and aims to become the
leading company from manufacturing to end-users. Traditionally, Illumina manufactures
instruments and pass them to the next intermediaries, which are service providers. However,
more recently Illumina has not only been manufacturing devices but also developing and
selling solutions directly to consumers. In such a dynamic and fast-growing market,
predicting the future of the industry is particularly difficult. Furthermore, firms face important
challenges when trying to sustain (and enhance) their competitive position. This is precisely
the challenge that Illumina is facing. Since the objective was to conduct and in depth analyze
the competitive situation of a company – Illumina –, the elaboration of a case study seemed to
be the most appropriate approach.
The work project is composed by a case study and a case discussion. The case study starts
with an overview of the Sequencing Market. We then describe Illumina’s positioning in terms
of market segments and products offered. After that, we present some facts about Illumina’s
performance. Finally, we leave some questions for discussion. The case discussion will focus
on the value creation potential of Illumina and the sustainability .
Summary, outcomes and action plan presented by Dr. Angela Christiano at the end of the two-day Alopecia Areata Research Summit held November 14-15, 2016 in New York, NY.
Visualization Tools for the Refinery Platform - Supporting reproducible resea...Nils Gehlenborg
The Refinery Platform (http://www.refinery-platform.org) is a web-based data visualization and analysis system for epigenomic and genomic data designed to support reproducible biomedical research. The analysis backend employs the Galaxy Workbench and connects to a data repository based on the ISA-Tab data description format. In my talk I will discuss the exploratory visualization tools that we have integrated into Refinery.
@EARLI19 paper on Professional Learning in the health sector in developing countries by Koula Charitonos (Open University, UK) and Allison Littlejohn (University of Glasgow, UK)
Reliability of Med-El Cochlear Implants in children. The Romania Experience.IJERA Editor
Introduction: Early detection of hearing loss significantly lowered the age of cochlear implantation. A failed CI
is a very problematic issue for the child and family and seems to be, for the moment, inevitable. This is a
retrospective review aimed to evaluate the reliability of Med-El devices implanted in children in Romania.
Materials and Methods: We designed a questionnaire to assess the incidence, the time elapsed and the reason
of total device failure. Medical-surgical data were collected from children who received Med-El cochlear
implants since the start of the National Cochlear Implant Program in 2001.
Results: There were 256 patients included. Failure Rate (6,64%) and Cumulative Survival Rate (95,31%) at 5
years were calculated. The majority of the hard and soft failures were encountered in Pulsar devices. Flap
necrosis was the most frequent medical/surgical reason for re-plantation. There was only one case of
posttraumatic device failure. Time elapsed to device failure was short – 22 months on average.
Conclusion: Cochlear implant reliability data should be considered during the choice of an implant for each
individual patient. This study confirms the safety and efficacy of Med-El cochlear implants in children for both
ceramic and non-ceramic devices.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
0 A Work Project, presented as part of the requireme.docxoswald1horne84988
0
A Work Project, presented as part of the requirements for the Award of a Masters
Degree in Management from the Nova School of Business and Economics
Illumina:
The sustainability of its competitive position
Marta Gonçalves Serra #1467
A project carried out on the Strategy course, under the supervision of
Professor Luís Almeida Costa
December 2014
1
Acknowledgements
I would like to sincerely thank my supervisor, Professor Luís Almeida Costa, for his
patient guidance, availability and advice he has given me throughout the course of this
project. His mentorship was essential for the success of this work and ultimately, for my
overall and round learning. I would also like to thank Stathis Kanterakis, member of the
Bioinformatics team at Illumina (Cambridge, United Kingdom) for all the information he
shared with me regarding Illumina and the Sequencing Market. He also made possible the
opportunity to visit Illumina’s site at Cambridge and to directly meet employees. All his
contributions were essential to get a greater insight of the company. Additionally, I would
also like to thank my sister, Eva Serra, currently a PhD student at Cambridge and the
Wellcome Trust Sanger Institute, for her continued support in terms of scientific and
technical understanding of the human genome area.
2
Introduction
This work project presents a case study about the sustainability of the competitive position of
Illumina in the Sequencing Market. This is a very recent market, which is growing at
unexpected rates and is contributing for many scientific discoveries. Illumina is currently the
market leader in the sequencing devices manufacturing business and aims to become the
leading company from manufacturing to end-users. Traditionally, Illumina manufactures
instruments and pass them to the next intermediaries, which are service providers. However,
more recently Illumina has not only been manufacturing devices but also developing and
selling solutions directly to consumers. In such a dynamic and fast-growing market,
predicting the future of the industry is particularly difficult. Furthermore, firms face important
challenges when trying to sustain (and enhance) their competitive position. This is precisely
the challenge that Illumina is facing. Since the objective was to conduct and in depth analyze
the competitive situation of a company – Illumina –, the elaboration of a case study seemed to
be the most appropriate approach.
The work project is composed by a case study and a case discussion. The case study starts
with an overview of the Sequencing Market. We then describe Illumina’s positioning in terms
of market segments and products offered. After that, we present some facts about Illumina’s
performance. Finally, we leave some questions for discussion. The case discussion will focus
on the value creation potential of Illumina and the sustainability .
Summary, outcomes and action plan presented by Dr. Angela Christiano at the end of the two-day Alopecia Areata Research Summit held November 14-15, 2016 in New York, NY.
Visualization Tools for the Refinery Platform - Supporting reproducible resea...Nils Gehlenborg
The Refinery Platform (http://www.refinery-platform.org) is a web-based data visualization and analysis system for epigenomic and genomic data designed to support reproducible biomedical research. The analysis backend employs the Galaxy Workbench and connects to a data repository based on the ISA-Tab data description format. In my talk I will discuss the exploratory visualization tools that we have integrated into Refinery.
@EARLI19 paper on Professional Learning in the health sector in developing countries by Koula Charitonos (Open University, UK) and Allison Littlejohn (University of Glasgow, UK)
Reliability of Med-El Cochlear Implants in children. The Romania Experience.IJERA Editor
Introduction: Early detection of hearing loss significantly lowered the age of cochlear implantation. A failed CI
is a very problematic issue for the child and family and seems to be, for the moment, inevitable. This is a
retrospective review aimed to evaluate the reliability of Med-El devices implanted in children in Romania.
Materials and Methods: We designed a questionnaire to assess the incidence, the time elapsed and the reason
of total device failure. Medical-surgical data were collected from children who received Med-El cochlear
implants since the start of the National Cochlear Implant Program in 2001.
Results: There were 256 patients included. Failure Rate (6,64%) and Cumulative Survival Rate (95,31%) at 5
years were calculated. The majority of the hard and soft failures were encountered in Pulsar devices. Flap
necrosis was the most frequent medical/surgical reason for re-plantation. There was only one case of
posttraumatic device failure. Time elapsed to device failure was short – 22 months on average.
Conclusion: Cochlear implant reliability data should be considered during the choice of an implant for each
individual patient. This study confirms the safety and efficacy of Med-El cochlear implants in children for both
ceramic and non-ceramic devices.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Dr. Vinod Kumar Kanvaria
Exploiting Artificial Intelligence for Empowering Researchers and Faculty,
International FDP on Fundamentals of Research in Social Sciences
at Integral University, Lucknow, 06.06.2024
By Dr. Vinod Kumar Kanvaria
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
1. Dear students get fully solved assignments
Send your semester & Specialization name to our mail id :
help.mbaassignments@gmail.com
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AEREN FOUNDATION’S Maharashtra Govt. Reg. No.: F-11724
Case Study Project
Total Marks: 100
SUBJECT - HOSPITAL ADMINISTRATION MANAGEMENT
N. B.: 1)Attempt any Four Questions
2)All questions carries equal marks.
Case Study 1
-- A New Approach to Managing GORD - ALTANA Pharma
ISSUES TO BE DISCUSSED
Q. 1. Discuss the salient features put up in the case.
AN ISO 9001 : 2008 CERTIFIED INTERNATIONAL B-
SCHOOL
2. Answer:Within the framework of its research and development efforts, ALTANA invests in
generatingknowledge.Thisresults,forexample,ininventionsthatALTANA protects with patents as
intellectual property.Butthisdoesnotearnthe company money. On the contrary, research initially
means spending money to generate knowledge.
Unlike adiscoveryoran invention,however,aninnovationismarkedbythe fact thatthe knowledge
generated creates value or benefits for our customers and for ALTANA. With the innovation,
therefore, knowledge is converted into value or benefits.
Q. 2. Evaluate the new approach based on your understanding of the case.
Answer: A newmethodhasbeen developed for diagnosing gastro-oesophageal reflux disease and
assessing treatment progress.
Until now, assessing the progress of treatment for Gastro-Oesaphageal Reflux Disease (GORD) has
reliedprimarilyonanassessment of oesophageal healing. Documenting GORD therapy success is a
difficult task, as mucosal damage does not always correspond with the severity of symptoms.1 In
addition, 70% of all patients with GORD symptoms have endoscopic-negative GORD.
Q. 3. The case indicates two research studies. Give your insights based on these two studies.
Answer:Asa focusedspecialty chemicals company, ALTANA offers its customers highly specialized
technological solutions in niche markets. Due to this business model, innovation is an important
element of the company’s corporate strategy, ensuring that ALTANA will keep growing in the long
term and remain the technology and market leader. ALTANA is therefore a research-intensive
company, which is reflected by the fact that 5 - 6 % of its sales are invested in research and
development – around twice as much as the industry
Case -2
A New Concept in Annuloplasty for Valve Repair: the
Biodegradable Ring - BIORING
ISSUES TO BE DISCUSSED
Q. 1. Bring out the facts as enumerated in the case.
3. Answer:The Kalangos® ring was developed for pediatric annuloplasty to preserve the growth
potential of the child's heart. It is also suitable for adult annuloplasty by extension. This now
commercially available device made of biodegradable polydioxanone induces the growth of
autologous fibrous tissue that reinforces the deficient annulus.
The good functioningof the native,orrepairedvalvedepends on coaptation capacity of its leaflets.
Annuloplasty rings have been used since 1968 to
Q. 2. Analyse the new concept at length in terms of Biodegradable principle.
Answer:Permanent metallic implants are key treatment options in cardiovascular interventions.
However, specific drawbacks limit their more widespread use. These limitations include
thrombogenicity, permanent physical irritation, mismatches in mechanical behaviour between
stented and non-stented vessel areas, long term endothelial dysfunction, inability to adapt to
growth,non-permissive or disadvantageous characteristics for later surgical revascularisation, and
chronic inflammatory local reactions. Degradable implants offer more physiological repair,
reconstitution of local vascular compliance, and a temporary, limited, longitudinal, and radial
straightening effect, including the possibility for growth
Case -3
Bone Substitutes to replace Transplantation?
Points to be addressed
Q. 1. Outline the salient facts of the case.
Answer:Tumours,bone cystsandtraumas,as well asosteomyelitisandosteolysis,cancause massive
bone loss. The primary method used today for filling such defects is autogenic or allogeneic bone
transplantation.Asbothapproachesare associatedwithconsiderable problems there is an ongoing
critical debate as to whether these procedures should still be considered the treatments of choice
Autogenic bone transplantation, for instance, is always associated with another surgery.
Q. 2. Discuss at length on the line of the salient features.
Answer:Properevaluationof the clinical successratesof tissueengineeringtechniques and products
has been hampered by a lack of consistency in the experimental techniques used to induce
periodontal defectsamongdifferentanimal groupsfor preclinical trials, as well as disparities in the
methods used to analyze outcomes obtained by different technologies. The most popular animal
4. models used for the assessment of periodontal regenerative protocols today involve ligature -
induced periodontal defects in nonhuman primates (
Case -4
Eliminating Latent TB
Issues to be Addressed
Q. 1. List out the facts of the case.
Answer:A diagnosisof latenttuberculosis(LTB),alsocalledlatenttuberculosisinfection(LTBI) means
a patient is infected with Mycobacterium tuberculosis, but the patient does not have active
tuberculosis. Active tuberculosis can be contagious while latent tuberculosis is not, and it is
therefore not possible to get TB from someone with latent tuberculosis. The main risk is that
approximately 10% of these patients (5% in the first two years after infection and 0.1% per year
thereafter) will go on to develop active tuberculosis.
Q. 2. Project your perception on the new standard brought out in the testing.
Answer:The global health community has set itself the task of eliminating tuberculosis (TB) as a
public health problem by 2050. Although progress has been made in global TB control, the current
decline in incidence of 2% yr−1 is far from the rate needed to achieve this. If we are to succeed in
thisendeavour,newstrategiestoreduce the reservoirof latentlyinfectedpersons (from which new
cases arise) would be advantageous. However, ascertainment of the extent and risk posed by this
group is poor. The current diagnostics tests (tuberculin skin test and interferon-gamma release
assays) poorly predict who will develop active disease and
Q. 3. Analyse the case example provided.
Answer:Tuberculosis is recognized as the world's leading bacterial cause of death. Yet 95% of
infectionisbelievedtoexistinanasymptomatic'latent'formthatis definednotbythe identification
of bacteria,butby the host immune response inthe formof reactivitytotuberculosisproteinsinthe
tuberculin skin test. It seems likely that clinically defined latent tuberculosis actually represents a
spectrumthat runsfrom eliminationof live bacilli tosubclinical disease:hence,itmightbe unhelpful
to use a single termto describe all these conditions. To support this view, here we focus on recent
5. increased understanding of the heterogeneity in both bacillary physiology and host immune
response that potentially illuminates new therapeutic and
Case-5 --Gamma Knife Surgery – Saving Lives and
Money?
Issues to Addressed
Q. 1. Identify the facts of the case.
Answer:
Q. 2. How would you consider this surgery as an innovative.
Answer:
Q. 3. What exactly is the recourse action the case tried to put forth in terms of saving life and
money?
Answer:
Dear students get fully solved assignments
Send your semester & Specialization name to our mail id :
help.mbaassignments@gmail.com
or
call us at : 08263069601