Pastor Oral Hazell's sermon discusses the significance of baptism in the Holy Spirit, emphasizing the Holy Spirit as a comforter, intercessor, and guide in truth. He highlights the benefits of being filled with the Holy Spirit, including victory over sin and boldness in ministry, and encourages believers to ask for the Holy Spirit's presence through faith and prayer. The sermon also explains the practice of speaking in tongues as a means of divine communication and intercession.