This document discusses the American Heart Association's precision medicine platform built on AWS. It describes how the platform securely stores and analyzes cardiovascular data to help researchers discover new insights. It outlines the architecture of the platform, including how it uses various AWS services like S3, EC2, RDS, and EMR for learning, searching and discovering from data, while ensuring security and compliance through services like IAM, CloudTrail, and KMS. The goal is to facilitate new approaches to research and improved patient outcomes through a networked, collaborative approach to precision medicine.

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AWS re:INVENT
The American Heart Association and How to Build a
Secure and Collaborative Precision Medicine
Platform on AWS
N o v e m b e r 2 7 , 2 0 1 7
H L C 3 0 9

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Let’s talk about data
What?

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Process Data Analyze Data Distribute Data
Secure Data Acquire Data Store Data
The Data Value Chain

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Data Lake as a Source of Truth

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Data Processing

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Data Analysis

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Data in Healthcare and Life Sciences

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Precision Medicine on AWS – E Pluribus Unum
Treat in context of
individual

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The AHA Precision Medicine Platform
Why?

10. THE GLOBAL IMPACT OF CARDIOVASCULAR
DISEASES AND STROKE
#1
17.5MDEATHS
EVERY 2SECONDS
someone around the world dies from
Cardiovascular disease.
Cardiovascular diseases are the cause of DEATH IN THE
WORLD.
The global cost of
Cardiovascular disease
is approximately
$900
BILLION
and will exceed $1 TRILLION
BY 2030
occur each year around the world from
Cardiovascular diseases.
GLOBAL IMPACT OF CARDIOVASCULAR DISEASES

11. Access Sharing Analytics Improved Patient
Outcomes
TECHNOLOGY TRANSFORMING SCIENCE:
IMPROVING HEALTH AND HEALTHCARE OUTCOMES

12. THE INSTITUTE FOR PRECISION CV MEDICINE

13. THE PROMISE OF PERSONALIZED MEDICINE

14. NEW TECHNOLOGY
AND CAPABILITIES
OLD MODELS
FOR DATA ACCESS AND ANALYTICS
WHAT PROBLEM
ARE WE TRYING TO SOLVE?

15. Data Mining Methods
Validation
Innovative
Development
Fellowship
Awards
DATA GRANTS ARE CRITICAL:
FACILITATING NEW APPROACHES TO DISCOVERY

16. A NETWORKED APPROACH IS NEEDED:
CREATING NEW PARADIGMS FOR RESEARCH

17. http://Precision.Heart.org, http://MyResearchLegacy.org
Prad.prasoon@heart.org, @PradPrasoon

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Compliant Technology – AHA-PMP
How?

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Concept
Learn Search Discover

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Concept—In Production
Learn Search Discover Secure &
Compliant
https://precision.heart.org

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Learn
Amazon
S3
Amazon
EC2
Amazon
RDS

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Search
Amazon ESAmazon
EC2
Amazon
S3

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Discover
Amazon
EMR
Amazon
S3
Amazon
AppStream 2.0*

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Secure and Compliant
Amazon
CloudWatch
AWS
CloudFormation
AWS
CloudTrail
AWS
Config
AWS
OpsWorks
AWS Certificate
Manager
AWS KMS
AWS WAF
AWS Shield
Amazon
Kinesis
Amazon
AppStream
AWS Step
Functions
AWS
CodeCommit
Amazon
VPC
AWS
Lambda
Amazon
Macie
Amazon EC2
Systems Manager
IAM

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Overall Architecture

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Automated Consistency

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Log Aggregation
Control Account
Prod Account
Researcher Account
x Many
Amazon
CloudWatch
Logs
Amazon
CloudWatch
Logs
Log Bucket
Amazon Kinesis
Streams
Lambda
function

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Patching and Config Monitoring
Automated Patch Management with EC2 Systems
Manager
• Pull System info into AWS Config
• Monitor installed software
State
Manager
Maintenance
Windows
Inventory Automation
Patch
ManagerAmazon EC2
Systems Manager

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Data and Environment Monitoring
Data Monitoring and Alerting
IAM Monitoring and Alerting
Data Access Monitoring

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More about the AHA-PMP
AHA/AWS Session
American Heart Association: Finding Cures to Heart Disease Through
the Power of Technology - ABD316
11/28/17 (Tuesday) 10:00 AM – Aria, Level 1, Pinyon 2

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Thank you!