The Greeks were the first to propose that matter is made of fundamental particles and developed early atomic theories, though Aristotle rejected atomism. Debate continued over what matter is made of (water, air, fire) until the 5th century BC when Leucippus and Democritus proposed the first atomic theory of tiny indivisible atoms. Though atomic theory was rejected for a time, scientists like Boyle, Newton and Lavoisier conducted experiments supporting atoms through discoveries like gases, gravity, and conservation of mass in chemical reactions.