Hinguvachadi - DRUG presentation

1. DRUG - PRESENTATION

2. INTRODUCTION
INGRIDIENTS IN YOGA
INDIVIDUAL DRUG REVIEW
RASAPANCHAKA
METHORD OF PREPARATION
DOSAGE $ ANUPANA
INDICATIONS
EXPERIENCE OF VARIOUS DOCTORS
AFI
AVAILABLE FORMS
MANUFACTURES
DISCUSSION
PROBABLE MODE OF ACTION IN PTSR

3.  This yoga mentioned in Astanga Hridaya
chikitsastana gulmaroga adyaya.
 Mentioned in sahasrayoyam all the
ingrideients are same .
 It is a choorna yoga.
 This contains saindava and kshara.
 Yoga contains 24 ingridients.

4. हिङ्गुवचाववजयापशुगन्धा-
दाडिमदीप्यकधान्यकपाठााः|
पुष्करमूलशठीिपुषाग्नि-
क्षारयुगत्रिपटुत्रिकटूनि||३१||
साजाग्जचव्यं सिनिवििीकं
सवेिसाम्लं ववनििग्न्ि चूर्णमम|

5. Bot.Name: Ferula Northex
Family: Apiaceae
Chemical cons:
Phellandrene,gummosin,kamolonol,polyanthinin,assafoetidin.
Uses:It is made as a pill and administer in rajo rodha avasta.
Choorna is used as anupana in various kashayas
In krimi chikitsa -when complaints of itiching,it is fried and powdered
and mixed with oil and apply on anus, immediate relief was seen.
Other formulations: Hinguvastaka choornam, Vaiswanarachoornam
etc

6. Rasa katu
Guna Teekshna,lagu,snigda
veerya ushna
Vipaka katu
karma Deepana ,chedana
pachana,anulomana,
vatasamana

7. VACHA
Bot. Name:Acorus Calamus
Family :Araecae
Chemical con:calamus oil.calalmine, calamole,asarone
Part used: Rizome
Uses: for wooping cough 50 mg vachachoorna in empty
stomach two times daily.
For medaya –bramhi and vacha 1gm with honey in empty
stomach in early morning
Other formulations: vijaya choorna, vachadi
taila,valliyarasnadi kashaya.. Etc.

8. RASA Katu,tikta
GUNA Laghu,tikshna
VIRYA ushna
VIPAKA katu
KARMA Vatakaphahara,
rujahara

9. Bot. Name:Terminalia Chebula
Family :Combretaceae
Chemical con:antraguinone,glycoside, chebulinic acid, tannic acid
Palmitic & stearic acid.
Other formulations: vijaya choornam, Abayaristam,triphala
choorna,agastya hareetaki, vaiswanarachoorna..
Adverse drug reaction: drug–disease interaction; example can be
cited as Terminalia chebula is contraindicated in pregnancy,
malnourished and anorexia conditions

10. RASA Kashayapradhana
lavanavarjitha
pancha rasa
GUNA Laghu,rooksha
VERYA ushna
VIPAKA madhura
KARMA Deepana,anulomana,
Anahahara,rasayana
Vibandahara.

11. Bot. Name: Withania Somniferra
Family :Solanaceae
Chemical con:Withanolides, withaferin,hygrine,choline,
somniferine,withnine.
Uses: aswaganda ksheerakashaya in vandyata(Shodala)
Nidranasa- choorna, grutha ,sita mixed and taken at night daily.
Other formulations: aswagandarista, aswaganda choorna,
aswaganda avaleha.

12. RASA Katu,tikta,kashaya
GUNA Snigdha,laghu
VERYA ushna
VIPAKA katu
KARMA Vrishya,rasayana,
vatakaphahara

13. Bot. Name:Punica granatum
Family :Punicacea
Chemical con: tannins,punicalin,punicicacid,ursolic acid.
Uses: atisara dadaim aphala twak kashaya.
Other formulations: dadimadi grutham,dadimastaka choornam,
gangadhara choorna
Parts used: fruits, stem bark

14. RASA Madhura,kashaya
anurasa
GUN Laghu,snigdha
VERYA ushna
VIPAKA madhura
KARMA Deepana,sukrala,
Vatakaphahara,hridya.

15. Bot. Name: Apium graveolans.
Family :Umbilliferae
Chemical con:Anthoxanins,luteolin,myristicic acid.
Uses:Udara soola choorna mixed with warm water and taken
internally.
Other formulations: ayamodakarka, hutaboothadi choorna
Parts used: Fruits.

16. RASA Katu,tikta
GUN Laghu,rooksha
VERYA ushna
VIPAKA katu
KARMA Deepana,
kapha vatahara,pachana

17. Bot. Name: Coriandrum Sataivum
Family : Apiaceae
Chemical con:Carotene cugenol, coriandrinol,coiandrin,
dihydrocoriandrin.
Uses: made into paste and given in garbhini chardi.
In conjuntivities phanta kashaya seka in eyes
Other formulations: shadanga choorna, guluchyadi kas, dhanyaka
hima.
Parts used: Fruits

18. RASA Katu
madhura,tikta,kashaya
GUN Laghu,snigdha
VERYA ushna
VIPAKA madhura
KARMA Deepana,pachana
tridoshahara

19. Bot. Name:Cissampelous pareira
Family :Menispermacieae
Chemical con:Hayatin,menismine,cissamine,cycleanine.
Uses:Arsas patha taken along with buttermilk.
Stana vidradhi patha leaves made into paste without adding
water and applied over the place.
Other formulations:Pushyanugachoorna, Shaddharana choorna.
Parts used:Root.

20. RASA Katu ,tikta
GUNA Laghu,tikshna
VIRYA ushna
VIPAKA katu
KARMA Pachana,deepana,
soolahara,gulmahara
Stanyasodhan,
Tridoshasaman.

21. Antifertility activity of the methanolic leaf extract of Cissampelos
pareira in female albino mice
The aim of the present study was to evaluate the validity of the antifertility effect of the
leaf extract.
Cissampelos pareira leaf extract, when administered orally, altered the estrous cycle
pattern in female mice, prolonged the length of estrous cycle with significant increase in
the duration of diestrus stage and reduced significantly the number of litters in albino
mice.
The analysis of the principal hormones involved in estrous cycle regulation showed that
the plant extract altered gonadotropin release (LH, FSH and prolactin) and estradiol
secretion.
The results indicated the antifertility effect of Cissampelos pareira leaf extract in female
albino mice. The oral LD50 of the extract was found to be 7.3 g/kg in mice.

22. Bot. Name:Innula Racemossa
Family :Asteracea
Chemical con:Alantolactone,lactone,isoalantolactone, betasitosterol
Uses: parswasoola choorna with honey(B.R)
Other formulations:Bhruhath yogaraja gulgullu, Hareetakyadi
choorna.
Part used: root.

23. RASA Tikta,katu
GUNA Laghu,rooksha
VIRYA seeta
VIPAKA katu
KARMA Parswasoolahara,admana
vinasanam,kasahara

24. Bot. Name:Hedichium Spicatum
Family :zingeberaceae
Chemical con:Hedychenone,7-hydroxyhedychenone.
Uses:chardi swarasa of rizhome along with honey.
Other formulations:Sathyadi choornam.
Parts used: Rizhome.

25. RASA Katu,tikta,
kashaya
GUNA Laghu,tikshna
VIRYA ushna
VIPAKA katu
KARMA Soolhara,vranahara
,kaphahara

26. Bot. Name:Juniperus communis
Family :Cupressaceae
Chemical con:Geigerone,Junenol, Junipegenin.
Uses:pradara it can be given ( r.ni)
Parts used: Fruits.
Formulations: chavikasavam, kumaryasavam

27. RASA Katu ,tikta
GUNA guru
VIRYA ushna
VIPAKA katu
KARMA Vatakapha hara.

28. Bot. Name:Plumbago zeylanica
Family :Plumbaginaceae
Chemical con: Plumbagic acid ,Chitranoneplumbagin,
elliptinone, maritone
Uses: Suddachitraka applied externally over arsas, it is alo used
in vardhama proyoga in skin problems under strict pathya.
Other formulations : chitrakadi vati, chitrakasava, shadharana
yoga.
Parts used : root( do shodhana in lime before using)

29. RASA katu
GUNA Laghu,rooksha
tikshna
VIRYA ushna
VIPAKA katu
KARMA Vahnikruth,
pachana,grahi,
vatakapha hara.

30. Materials and methords: Ethanolic extract of dried root and callus was obtained
SwissAlbino male rats weighing 20 to 30 grms are taken for study purpose.
Test compounds: Root extract (ethanol) - 100, 200 and 400 mg/kg
Callus extract (ethanol) - 100, 200 and 400mg/kg .
Standard drug: Pentazocine 5 mg/kg and Indomethacin 10 mg/kg.
Vehicle: The extracts and indomethacin were suspended in 0.5% carboxy
methyl cellulose and given per orally. pentazocine was dissolved in normal
saline and were injected intraperitoneally.
Screening of analgesic activity : Peripheral analgesic activity of extracts were
investigated by glacial acetic acid.The abdominal stretching were observed and
counted for 20 minutes after administration of glacial acetic acid. The central
analgesic activity was assessed by tail immersion test in which tail of mice was
entirely immersed in water at temperature about 58°C and time until withdrawl
of tail was measured by stop watch

31. .Discussion :Analgesic effect of P. zeylanica root extract (PRE) and callus
extract (PCE) was studied for central (opiod) and peripheral (non opiod)
activity. Results of study reveals that analgesic effect of PRE was comparable to
that of Indomethacin. Relief of pain by Indomethacin is due to suppressing the
formation of pain substances in the peripheral tissues, where prostaglandins
and bradykinin were suggested to play an important role in pain perception .
Therefore it is likely that extracts might suppress the formation of these
substances and show analgesic activity in peripheral pain model. In tail
immersion model, PRE (400 mg/kg p.o.) significantly increase the reaction
time suggesting its central analgesic activity. Plumbago zeylanica was
reported to possess the flavonoids, and flavonoids were known to inhibits
the prostaglandins synthetase . Since prostaglandins are involved in pain
perception, it could be suggested that nonavailability of prostaglandin by
flavonoids of PRE, might be possible for its analgesic effect.
Conclusion: In conclusion, present attempt revealed that the ethanolic extract
of root and callus possess significant peripheral analgesic activity whereas as
the root extract possess significant central analgesic activity as compared to
callus extract.

32. Bot name: zingeber officinale
Family: zingiberaceae
Chemical costituents:
campherene,curcumine,bourbornene,borneal,citrial,gingereno
ne,gingerglycolipids
A,B,$C,gingerols,paradol,gingerdiol,gingerone .
Formulations:
Soubagya sunti modaka,Panchakola choorna,Chitrakadi vati
Flocuar uses:
soothikas as swarasa just after delivery along with honey.
Pain ful mensturation swarasa with honey or curry prepared
and given.

33. RASA Katu ,tikta,kashaya
GUNA Laghu,tikshna
VIRYA ushna
VIPAKA mahura
KARMA Vatakaphahara,deepa
na,bedana.

34. Botanical name: Pipper nigrum
Family:Piperaceae
Chemical constituents:Pipperine,citronellol,cryptone,pippecolic
acid,carotene,ascorbic acid
Uses: used as anupana in various kashayas.
Formulations: trikatu choorna, agnitunti vati.
Parts used: fruit

35. RASA katu
GUN Laghu,tikshna
VERYA ushna
VIPAKA katu
KARMA Kaphavatahara
deepana

36. Cytotoxicity Screening of Plants of Genus Piper in Breast Cancer Cell Lines
Tropical Journal of Pharmaceutical Research June 2014; 13 (6): 921-928
AIM:To find anticancerous effect of 7 species of pipper.
Methord: 4,5-dimethylthiazol-2-yl -2,5-diphenyltetrazolium bromide were
used in normal breast cells and cancerous cells, dried plants were extracted with
methanol and dichloromethane, and the effective extract isolated by
crystallization, acid/base extraction and column chromatography techniques.
Result:Extracts of Piper retrofractum, Piper betle, especially Piper nigrum,
exhibited strong effect on MDA-MB-468. When the crude extract of P. nigrum
was then separated by column chromatography, fraction D showed activity
against both MCF-7 and MDA-MB-468 cells

37. Botanical name:Pipper longum
Family: Pipperaceae
Chemical constituent: pippercide,sesamine,pipperlactum,
pipperlartine
Uses: chardi given with honey.
Formulations:vyoshadi vadakam,pipplyadi avaleha
Parts used: fruits
Adverse drug reaction: Piper longumDravyataha atisevana
Qualitative over dose (Gunataha atisevana)
Disorders like impotency, dryness of mouth, refractive error,
lean, fainting and diarrhoea .

38. RASA Katu
GUNA Laghu,Tikshna
VERYA ushna
VIPAKA madhura
KARMA Kaphavatahara,dee
epana

39. Bot. Name:Cuminum cymium
Family :Apiaceae
Chemical con:Apin,Cumin,Cuminaldehyde
Uses:jeeraka siddajala used in vata kopa(adopa,admana)
Other formulations: jeerakarista, jeerakadimodaka..

40. RASA Katu,tikta
GUNA Laghu,rooksha,tikshna
VERYA ushna
VIPAKA katu
KARMA Deepana,pachana,
vatakaphahara,
admanahara,
garbasayasodhana

41. Bot. Name:Piper chaba
Family :Piperaceae
Chemical con:Piperene,sitosterol,piplartine.
Uses:udara- chavya and ardraka along with milk.
Other formulations: chitrakadi
vati,panchakolachoorna,kankayana vati.
Prats used: Root.

42. RASA katu
GUNA Laghu,rooksha
VIRYA ushna
VIPAKA katu
KARMA Kaphavatahara,
deepana,pachana

43. Bot. Name:Rhus parviflora
Family :Anacardaeceae
Chemical con: Tannins
Other formulations: vyoshadi vadaka
Partrs used: fruits.

44. RASA amla
GUNA Laghu,rooksha
VERY
A
seeta
VIPA
KA
amla
KAR
MA
Deepana,grahi,ruchyam,
vatakaphaharam

45. Anti-HIV-1 activity, protease inhibition and safetyprofile of extracts
prepared from Rhus parviflora.
Methods: Aqueous and 50% ethanolic extracts prepared from leaves of the plant
were tested for their cytotoxicityand anti-HIV property using reporter gene based
assays as well as human peripheral blood lymphocytes (PBLs).Further these
extracts were evaluated for their ability to inhibit HIV-1 reverse transcriptase (RT)
and protease activitY
RESULT:Aqueos and etanolic extract shows anti-HIV activity in TZM-bl cells.
Both the extracts also inhibited virus load in HIV infected CEM-GFP cells and
human PBLs.

46. Bot. Name: Garcinia pedunculata
Family : Guttiferae
Chemical con:Pedunculol,garcinol,cambogin.
Uses: Asmari powder of hingu ,hapusha,kantakari,bruhathi and
amlavetasa is used.
Other formulations: vidangadi chooornam

47. RASA amla
GUN Laghu, rooksha,
VERYA ushna
VIPAKA amla
KARMA Bedana,
deepana,anulomana

48. DRUG RASA GUNA VIRYA VIPAK
A
KARMA
HINGU Katu Tikshna Ushna katu Pchana,deepana,c
hedana,
anulomana,soolah
ara, gulmahara
VACHA Katu,Tikta Laghu
tikshna
Ushna Katu Vatasleshmarujah
ara,soolahara
VIJAYA Kashaya
pradhan 5 rasa
exept lavan
Laghu
Rooksha
Ushna Madhur
a
Deepana,anuloma
na,vibandahara
PASUGAND
A
Katu,Tikta,
Kashaya
Snigda
Laghu
Ushna Katu Vrishya,Rasayana
Vatakapha hara
DADIMA Madhura
kashaya (anu)
Laghu
Snigdha
Ushna Madhur
a
Sukrala,deepana
Vata kaphapaha
DEEPYAKA Katu
Tikta
Laghu
Rooksha
Ushna Katu Deepana,
pachana,bastiruk
hara,kapha vata
hara
DHANYAK Lagu Usna Madhur Deepana, pachana

49. PATA Katu,
Tikta
Laghu
Tikshna
Ushna Katu Pachana,
Deepana,Gul
mahara
PUSHKARA
MOOLA
Tikta
Katu
Laghu
Rooksha
Seeta Katu Parswasoolaha
r,anahahar
SHATHI Katu, Tikta ,
Kaashaya
Laghu
Tikshna
Usna Katu Vrana,
soolahara
HAPUSHA Katu, tikta Guru Ushna Katu vatakapha
hara
deepana
AGNI katu Laghu,Ruksa
, Tikshna
Usna Katu Pachana,
Deepana
Vatakaphaha
SARJA
KSHARA
katu Laghu,
rooksha
snigda
ushna katu Deepana,
pachana,
gulma,
admanahara
YAVA
KSHARA
katu Laghu
Snigdha
sara
ushna katu Deepana
pachana
admanahara
kaphavatahara

50. SOUVARC
HALA-
LAVANA
Lavana,
Madhura
Laghu,
Snigdha,
Sukshma,
Vishada
ushna katu Kapha-vata
hara,
Deepana,
Bhedana,
Anulomana,
Shoolahara,
Avidahi
SUNTI katu Guru,Rooksha
,
Tikshna
ushna madhura Vatakapha
hara,
Deepana,Bhed
ana
MARICHA katu Laghu
tikshna
ushna katu Kaphavata
hara,dipana
PIPPALI katu Laghu,snigd
ha
ushna madhura Vatakphaha
ra,deepanam
AJAJI Katu,tikta Laghu,rooks
ha,tikshna
ushna katu Deepana,pac
hana,adman
a,vatakaphh
ahara
CHAVYA katu Laghu, ushna katu Kaphavatah

51.  All the ingridients are taken equally and
powedered and mixed together and add the
binding agent and made pills weigh 125 mg in
tablet punching machine.the prepared tablets
are kept in air tight container.

52.  1 tab= 125 mg( 2-0-2)
 Choorna( 5-10) grms.
 ANUPANAM:
Warm water
Kashaya
Arista
Takra.

53. हृत्पार्शवमबग्तित्रिकयोनिपायु-
शूलानि वाय्वामकफोद्भवानि||३२||
कृ च्छ्राि गुल्माि वािववण्मूिसङ्गं
कण्ठे बन्धं हृद्रिं पाण्िुरोगम|
अन्िाश्रद्धाप्लीिदुिाममहिध्मा-
वध्मामध्मािर्शवासकासाग्निसादाि||३
३

54.  SOOLA-
Hridaya,Parswa,Basti,
Trika, yoni, payu.
Vata kaphaja roga.
Vata,vid, mootra sanga
Mootrakrichra,gulma
Kanda banda
hridroga,panduroga
Arsas,hidma
Swasa,kasa,angnisada
Adhmana.
Hidma,pleeharoga,stana
and kukshiroga.

55.  1. Hingu (Exd.) 1 Part
 2. Vacha (Rz.) 1 Part
 3. Vijaya (Har¢tak¢) (P.) 1 Part
 4. Pasugandha (Ajagandh¡) (Pl.) 1 Part
 5. Dadima (Dr. Sd.) 1 Part
 6. Depyaka (Yav¡ni) (Fr.) 1 Part
 7. Dhanyaka (Fr.) 1 Part
 8. Patha (Rt.) 1 Part
 9. Pushkara (Rt.) 1 Part
 10. shati (Rz.) 1 Part
 11. Hapusha (Fr.) 1 Part

56. 12. Agni (Citraka) (Rt.) 1 Part
13. Yava ksh¡ra (Yava) (Pl.) 1 Part
14. svarjika kshara (svarji kÀ¡ra) 1 Part
15. Saindhava lavana 1 Part
16. Sauvarcala Lavana 1 Part
17. Vida Lavana 1 Part
18. sunti (Rz.) 1 Part
19. Marica (Fr.) 1 Part
20. Pippali (Fr.) 1 Part
21. Ajaji (Fr.) 1 Part
22. Cavya (St.) 1 Part
23. Tintinika (Fr. P.) 1 Part
24. Vetasamla (Fr.P) 1 Part

57.  Choorna is used as kalka in lekkhana vasti(
kapha medo hara) eg: hypothyroidism,pcos,
sthoulya etc..
 In amavata and vatarakta as a part of samana
oushada hinguvachadi choorna is given.

58.  Choornam
 tablet

59. Vaidyaratnam-100tab – 270Rs.
Bhipha- 90 tab -175 Rs.

60.  RASA- katu-18,tikta-9,kashaya-6,madhura -4,
alma$ lavana-3.
 GUNA-laghu-19,rooksha-9,tikshna$ snigdha-8.
 VERIYA- ushna-22,setha-2.
 VIPAKA- katu-15, madhura-7,amla-2.
 KARMA-deepana-19,pachana-10,anulomana-5
Vatakaphasamana-13.
DOSHA SAMANA- kapha vata
DHATHUS-Rasa, medas,asthi
SROTHAS- sanga

61.  Udavarthini yoni vyapath choorna along with
grutha.
 In breast tendernessand in fibroadenosis tablet
can be given with kashaya suitable for the
avastha.
 Since most of the drugs are having vatakapha
samana and it contains kshara and lavana it
can have lekhana property hence can be used
in those conditions when lekhana is needed.
 It will remove the srothosanga(arthavavaha),
and also helps in ovulation.

62.  It can be used as deepana pachana purpose
prior to snehapana.
 Given in pcos conditions along with suitable
medicines.
SAMANA YOGA:
CHITRAKADI VADI
VAISWANARA CHOORNA
HINGUVASTAKACHOORNA…

63. THANK YOU