This document discusses two paradigms that characterize research in the information systems discipline: behavioral science and design science. Behavioral science seeks to develop and verify theories to explain human and organizational behavior related to information systems. Design science seeks to extend human and organizational capabilities by creating new and innovative information system artifacts. The goal is to describe design science research through a conceptual framework and guidelines. Three exemplars are discussed to demonstrate applying the guidelines. Both paradigms are foundational to the information systems discipline given its focus on people, organizations, and technology.