Heredity, Mendelian ways of inheritance

1. 1 Heredity vl nas @ 2013 Mendelian ways of inheritance Véronique Nas 4 October 2013

2. three ways of inheritance 1 autosomal dominant 2 autosomal recessive 3 x-‐linked Heredity autosomal = not on the sex chromosomes x-‐linked = on the female sex chromosome vl nas @ 2013 2

3. autosomal domininant: one mutated gene will do Heredity vl nas @ 2013 3

4. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) Heredity vl nas @ 2013 3

5. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) Heredity vl nas @ 2013 3

6. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes Heredity vl nas @ 2013 3

7. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes Heredity vl nas @ 2013 3

8. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene Heredity vl nas @ 2013 3

9. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene Heredity vl nas @ 2013 3

10. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene and the man passes on a healthy gene Heredity vl nas @ 2013 3

11. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene and the man passes on a healthy gene Heredity vl nas @ 2013 3

12. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant Heredity vl nas @ 2013 3

13. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant Heredity vl nas @ 2013 3

14. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant Heredity vl nas @ 2013 3

15. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant Heredity vl nas @ 2013 3

16. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant and the man passes on again a healthy gene Heredity vl nas @ 2013 3

17. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant and the man passes on again a healthy gene Heredity vl nas @ 2013 3

18. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant and the man passes on again a healthy gene than the child will have two healthy genes and no disease Heredity vl nas @ 2013 3

19. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant and the man passes on again a healthy gene than the child will have two healthy genes and no disease Heredity vl nas @ 2013 3

20. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene whether it is a girl ... and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant and the man passes on again a healthy gene than the child will have two healthy genes and no disease Heredity vl nas @ 2013 3

23. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene whether it is a girl ... and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant and the man passes on again a healthy gene than the child will have two healthy genes and no disease ... or a boy Heredity vl nas @ 2013 3

24. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene whether it is a girl ... and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant and the man passes on again a healthy gene than the child will have two healthy genes and no disease ... or a boy every child has a 50% chance to inherite the disease Heredity vl nas @ 2013 3

25. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene whether it is a girl ... and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant and the man passes on again a healthy gene than the child will have two healthy genes and no disease ... or a boy every child has a 50% chance to inherite the disease an example is Wagner syndrome, a disease of the reLna and vitreous, associated with many reLnal detachments Heredity vl nas @ 2013 3

26. autosomal domininant: one mutated gene will do let’s say the woman has an inherited disease, she will have a healthy gene (green) and a mutated gene (orange) she marries a healthy man with two healthy genes if the woman passes on her mutated gene if the woman passes on her healthy gene whether it is a girl ... and the man passes on a healthy gene than the child will have the disease as the mutated gene is dominant and the man passes on again a healthy gene than the child will have two healthy genes and no disease ... or a boy every child has a 50% chance to inherite the disease an example is Wagner syndrome, a disease of the reLna and vitreous, associated with many reLnal detachments Heredity vl nas @ 2013 3

27. autosomal recessive: only 2 mutated genes cause the disease Heredity vl nas @ 2013 4

28. autosomal recessive: only 2 mutated genes cause the disease Heredity vl nas @ 2013 4

29. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) Heredity vl nas @ 2013 4

30. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease Heredity vl nas @ 2013 4

31. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease Heredity vl nas @ 2013 4

32. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease there are four possibiliLes Heredity vl nas @ 2013 4

33. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease there are four possibiliLes woman healthy gene + man healthy gene = healthy child, no mutated genes Heredity vl nas @ 2013 4

37. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease there are four possibiliLes woman healthy gene + man healthy gene = healthy child, no mutated genes woman healthy gene + man sick gene = healthy child, one mutated gene Heredity vl nas @ 2013 4

41. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease there are four possibiliLes woman healthy gene + man healthy gene = healthy child, no mutated genes woman healthy gene + man sick gene = healthy child, one mutated gene woman sick gene + man healthy gene = healthy child, one mutated gene Heredity vl nas @ 2013 4

45. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease there are four possibiliLes woman healthy gene + man healthy gene = healthy child, no mutated genes woman healthy gene + man sick gene = healthy child, one mutated gene woman sick gene + man healthy gene = healthy child, one mutated gene woman sick gene + man sick gene = child with the disease, two sick genes Heredity vl nas @ 2013 4

49. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease there are four possibiliLes woman healthy gene + man healthy gene = healthy child, no mutated genes woman healthy gene + man sick gene = healthy child, one mutated gene woman sick gene + man healthy gene = healthy child, one mutated gene woman sick gene + man sick gene = child with the disease, two sick genes every child has a 25% chance of inheriLng the disease Heredity vl nas @ 2013 4

50. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease there are four possibiliLes woman healthy gene + man healthy gene = healthy child, no mutated genes woman healthy gene + man sick gene = healthy child, one mutated gene woman sick gene + man healthy gene = healthy child, one mutated gene woman sick gene + man sick gene = child with the disease, two sick genes every child has a 25% chance of inheriLng the disease whether it is a girl or a boy Heredity vl nas @ 2013 4

51. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease there are four possibiliLes woman healthy gene + man healthy gene = healthy child, no mutated genes woman healthy gene + man sick gene = healthy child, one mutated gene woman sick gene + man healthy gene = healthy child, one mutated gene woman sick gene + man sick gene = child with the disease, two sick genes every child has a 25% chance of inheriLng the disease whether it is a girl or a boy 75% of the children has a mutated gene. they can only pass on the disease to their children if they marry a spouse with also a mutated gene Heredity vl nas @ 2013 4

52. autosomal recessive: only 2 mutated genes cause the disease both parents have a healthy gene (green) and a mutated one (yellow) as the healthy gene is dominant, neither of the parents carry the disease only if both parents pass on the mutated gene to their child, it will inherite the disease there are four possibiliLes woman healthy gene + man healthy gene = healthy child, no mutated genes woman healthy gene + man sick gene = healthy child, one mutated gene woman sick gene + man healthy gene = healthy child, one mutated gene woman sick gene + man sick gene = child with the disease, two sick genes every child has a 25% chance of inheriLng the disease whether it is a girl or a boy 75% of the children has a mutated gene. they can only pass on the disease to their children if they marry a spouse with also a mutated gene an example is cysLc ﬁbrosis Heredity vl nas @ 2013 4

53. x-‐linked: on the female sex chromosome, only boys at risk Heredity vl nas @ 2013 5

54. x-‐linked: on the female sex chromosome, only boys at risk woman: two X-‐chromosomes Heredity vl nas @ 2013 5

55. x-‐linked: on the female sex chromosome, only boys at risk woman: two X-‐chromosomes man: one Y-‐chromosome and one X-‐chromosome Heredity vl nas @ 2013 5

56. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender woman: two X-‐chromosomes man: one Y-‐chromosome and one X-‐chromosome Heredity vl nas @ 2013 5

57. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes man: one Y-‐chromosome and one X-‐chromosome Heredity vl nas @ 2013 5

58. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes let’s say that on one of the X-‐chromosomes of a woman there is a mutated gene man: one Y-‐chromosome and one X-‐chromosome Heredity vl nas @ 2013 5

61. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes let’s say that on one of the X-‐chromosomes of a woman there is a mutated gene man: one Y-‐chromosome and one X-‐chromosome than we heve four possibiliLes Heredity vl nas @ 2013 5

62. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes let’s say that on one of the X-‐chromosomes of a woman there is a mutated gene woman healthy X + man X-‐chromosome = healthy girl, no mutated genesman: one Y-‐chromosome and one X-‐chromosome than we heve four possibiliLes Heredity vl nas @ 2013 5

66. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes let’s say that on one of the X-‐chromosomes of a woman there is a mutated gene woman healthy X + man X-‐chromosome = healthy girl, no mutated genes woman sick X + man X-‐chromosome = healthy girl, one mutated gene the healthy X makes the girl not having the disease man: one Y-‐chromosome and one X-‐chromosome than we heve four possibiliLes Heredity vl nas @ 2013 5

70. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes let’s say that on one of the X-‐chromosomes of a woman there is a mutated gene woman healthy X + man X-‐chromosome = healthy girl, no mutated genes woman sick X + man X-‐chromosome = healthy girl, one mutated gene the healthy X makes the girl not having the disease woman healthy X + man Y-‐chromosome = healthy boy man: one Y-‐chromosome and one X-‐chromosome than we heve four possibiliLes Heredity vl nas @ 2013 5

74. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes let’s say that on one of the X-‐chromosomes of a woman there is a mutated gene woman healthy X + man X-‐chromosome = healthy girl, no mutated genes woman sick X + man X-‐chromosome = healthy girl, one mutated gene the healthy X makes the girl not having the disease woman healthy X + man Y-‐chromosome = healthy boy woman sick X + man Y-‐chromosome = boy with the disease man: one Y-‐chromosome and one X-‐chromosome than we heve four possibiliLes Heredity vl nas @ 2013 5

78. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes let’s say that on one of the X-‐chromosomes of a woman there is a mutated gene woman healthy X + man X-‐chromosome = healthy girl, no mutated genes woman sick X + man X-‐chromosome = healthy girl, one mutated gene the healthy X makes the girl not having the disease woman healthy X + man Y-‐chromosome = healthy boy woman sick X + man Y-‐chromosome = boy with the disease girls are never aﬀected themselves but half of them carry the mutated gene that can be passed on to her children man: one Y-‐chromosome and one X-‐chromosome than we heve four possibiliLes Heredity vl nas @ 2013 5

79. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes let’s say that on one of the X-‐chromosomes of a woman there is a mutated gene woman healthy X + man X-‐chromosome = healthy girl, no mutated genes woman sick X + man X-‐chromosome = healthy girl, one mutated gene the healthy X makes the girl not having the disease woman healthy X + man Y-‐chromosome = healthy boy woman sick X + man Y-‐chromosome = boy with the disease girls are never aﬀected themselves but half of them carry the mutated gene that can be passed on to her children boys have a 50% chance of inheriLng the disease man: one Y-‐chromosome and one X-‐chromosome than we heve four possibiliLes Heredity vl nas @ 2013 5

80. x-‐linked: on the female sex chromosome, only boys at risk on the (liSle) Y-‐chromosome there are almost only genes that determine the gender on the larger X-‐chromosome there are genes that determine the gender but also some other genes woman: two X-‐chromosomes let’s say that on one of the X-‐chromosomes of a woman there is a mutated gene woman healthy X + man X-‐chromosome = healthy girl, no mutated genes woman sick X + man X-‐chromosome = healthy girl, one mutated gene the healthy X makes the girl not having the disease woman healthy X + man Y-‐chromosome = healthy boy woman sick X + man Y-‐chromosome = boy with the disease girls are never aﬀected themselves but half of them carry the mutated gene that can be passed on to her children boys have a 50% chance of inheriLng the disease man: one Y-‐chromosome and one X-‐chromosome than we heve four possibiliLes an example is hemophilia that ran in the Russian tsar family Heredity vl nas @ 2013 5

Heredity, Mendelian ways of inheritance

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

Similar to Heredity, Mendelian ways of inheritance

Similar to Heredity, Mendelian ways of inheritance (20)

Recently uploaded

Recently uploaded (20)

Heredity, Mendelian ways of inheritance