Handbook on Active Pharmaceutical Ingredients (API), Drugs & Pharmaceutical Products

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1. INTRODUCTION
1.1 The Pharmaceutical Sector
1.2 Research, Development and Exploration
1.3 Ahead-of-Clinical Trials
1.4 Product Validation
1.5 The Value and Significance of Pharmaceutical Quality
1.6 Use
2. HOW TO A START PHARMACEUTICAL MANUFACTURING
2.1 Steps to Set up a Pharmaceutical Manufacturing
2.1.1 Choose an Appropriate Name for the Company
2.1.2 How Do Register?
2.1.3 Manufacturing License Procedure and Documents Required
2.1.4 Goods and Service Tax (GST) Registration
2.1.5 Machineries and Analytical Equipments
3. TYPES OF TABLET AND ITS MANUFACTURING PROCESS
3.1 Types
3.1.1 Pills
3.1.2 Caplets
3.1.3 Orally Disintegrating Tablets (ODT)
3.1.4 Film Coated Tablets (FCT)
3.2 Tabletting Formulations
3.3 The Making of the Tablets
3.3.1 Tablet Compaction Simulator Packaging

3.3.2 Tablet Presses
3.3.3 Tablet Coating
3.4 Tablet Manufacturing Processing
3.4.1 Sizing
3.4.2 Powder Blending
3.4.3 Granulation
3.4.4 Drying
3.4.5 Tablet Compression
3.4.6 Coating and Polishing Machines
3.4.7 Tablet Testing
3.4.8 Tablet Deduster
3.4.9 Fette Machine
3.4.10 Physical Features of Compressed Tablets
3.4.11 Packaging
4. TABLET COATING PROCESS
4.1 Principles of Tablet Coating
4.2 Primary Components Involved in Tablet Coating
4.2.1 Tablet Properties
4.2.2 Coating Process, Design & Control
4.2.3 Coating Equipment
4.3 Traditional Coating Techniques
4.3.1 Sugar Coating

4.3.2 Film Coating
4.3.3 Enteric Coating
4.3.4 Press Coating
4.4 Equipment
4.4.1 Standard Coating Pan
4.4.2 Perforated Pan Coating
4.4.3 Fluidized Bed Coater
4.5 Principle of Operation
4.6 Process Advantages
4.7 Advantages of Tablet Coating
5. PARACETAMOL TABLET MANUFACTURING
5.1 Chemistry
5.2 Mechanisms of Actions
5.3 Pharmacokinetics
5.4 Physical Properties
5.5 Formation of Paracetamol
5.6 Types of Paracetamol
5.7 Synthesis of Paracetamol
5.7.1 Phenol Route
5.7.2 P-Nitrochlorobenzene Route
5.7.3 Nitrobenzene Route

5.7.4 Hoechst-Celanese process (p-Hydroxyaceto-phene Hydrazine Route)
5.8 Paracetamol on the Pharmaceutical Market
5.9 Process of Tablet Manufacturing
5.9.1 Dry Mixing
5.9.2 Drying
5.9.3 Wet Granulation
5.9.4 Binder Solution Preparation
5.9.5 Compression
5.10 Evaluation Parameters of Tablet for Process
Validation
5.10.1 Content Uniformity
5.10.2 Weight Variation
5.10.3 Thickness
5.10.4 Hardness
5.10.5 Friability
5.10.6 Dissolution Test
5.10.7 Disintegration Test
6. METRONIDAZOLE TABLET
6.1 Medical Uses
6.1.1 Bacterial Vaginosis
6.1.2 Trichomoniasis
6.1.3 Giardiasis
6.1.4 Dracunculus

6.2 Materials and Procedures
6.2.1 Wet Granulation
6.2.2 Dry Granulation
6.2.3 Direct Compression
6.2.4 Tablet Evaluation
6.2.5 Weight Uniformity Test
6.2.6 Crushing Strength/Hardness Test
6.2.7 Friability Test
6.2.8 Content Uniformity Test
6.2.9 Disintegration Test
6.2.10 Dissolution Test
7. ASPIRIN MANUFACTURING
7.1 Introduction
7.2 Chemical Properties
7.3 Synthesis
7.4 Physical Properties
7.4.1 Polymorphism
7.5 Uses
7.5.1 Ache and Enlargement
7.5.2 Treating Heart Attacks
7.5.3 Preventing Heart Attacks and Strokes
7.6 Raw Materials

7.7 Manufacturing Process
7.7.1 Weighing
7.7.2 Mixing
7.7.3 Dry Screening
7.7.4 Compression
7.7.5 Testing
7.7.6 Bottling and Packaging
8. IV FLUIDS PRODUCTION
8.1 Introduction
8.2 Types of IV Fluids
8.3 Crystalloids
8.3.1 Isotonic IV Fluids
8.3.2 Hypotonic IV Fluids
8.3.3 Hypertonic IV Fluids
8.4 Colloids
8.5 Human Albumin
8.6 Dextrans
8.7 Etherified Starch
8.8 Gelatin
8.9 Plasma Protein Fraction (PPF)
8.10 Intravenous Fluids Used
8.11 Effects of Dehydration

8.12.1 Preparation of Distilled Water
8.12.2 Solution Creation
8.12.3 Filling and Filtration
8.13 Intravenous Solutions Market
9. OINTMENT MANUFACTURING
9.1 Introduction
9.2 Types
9.2.1Non Medicated Ointments
9.2.2Medicated Ointments
9.3 Ointments According to Penetration
9.4 Advantages
9.5 Ointment Applications
9.6 Type of Preparation
9.6.1 Ointment Prepared by Trituration
9.6.2 Ointment Preparation by Chemical Reaction
9.6.3 Preparation of Ointments by Emulsification
9.7 Properties of the Ointment Manufacturing Plant
9.8 Advantages of Ointment Manufacturing Plant
9.9 Manufacturing Procedure of Ointment
9.10Parts of Ointment Manufacturing Plant
10. LIQUID GLUCOSE MANUFACTURING
10.1 Molecule of Glucose (Glucose Chemical Structure)
10.2 Specifications of Glucose

10.3 Formula of Glucose and Fructose
10.3.1 Formula for D-Glucose
10.3.2 Carbon Anomer in Glucose
10.3.3 Carbohydrates have an Open Chain Structure
10.3.4 Formula for a Fructose Molecule
10.3.5 Fructose has a Cyclical Structure
10.3.6 Structure of Glucose in Cycles
10.3.7 Glucose’s Furanose Structure
10.4 Glucose’s Chemical Properties
10.4.1 Glucose Oxidation to Create Sugar Acids
11.SURGICAL COTTON PRODUCTION PROCESS
11.1 Required Raw Materials and Their Availability
11.2 Process of Fabrication
11.3 Machinery & Equipment Required for the
Manufacturing
11.3.1 Blower Room Device
11.3.2 Bleaching Intensity
11.3.3 Hydraulic Extractor
11.3.4 Dryer
11.3.5 Lapping Device
11.3.6 Carding Device
11.3.7 Rolling Device

11.3.8 Cutting Device
11.3.9 Packaging Equipment
11.4 Business Outlook and Trend
12. HOW TO START A BUSINESS OF SURGICAL COTTON
12.1 Machine Required
12.2 Necessary Raw Materials to Create Surgical Cotton
12.3 Registration and Licensing
12.4 Documents Needed to Apply For a Licence to Operate a Business Manufacturing Surgical Cotton
12.5 Fabrication of Surgical Cotton
13. PRODUCTION OF SYRUP
13.1 Benefits of Syrups
13.2 Why Syrups Used?
13.3 Ingredients in Syrups
13.4 Formulation of Sugar Based Syrups
13.4.1 Sucrose Solutions in Aqueous Forms: Stability
13.5 Advantages of Sucrose
13.6 Syrup Preparation
13.6.1 A Heat-Assisted Solution
13.6.2 Agitation-based Solution without Heat
13.6.3 Percolation
13.7 Dextrose Based Syrup
13.8 Utilizing Solubilization in the Formulation of Syrup
13.9 Synthesis of Artificial Syrups

13.9.1 Sugar-Free Syrups
13.10 Sorbitol-Based Syrup
13.11 Application of Syrups
13.12 Method of Preparation for Syrups
13.13 Process
14. VARIOUS TECHNIQUES FOR MAKING PHARMACEUTICALLY ACCEPTABLE SALTS
15. HOW IS ACTIVE PHARMACEUTICAL INGREDIENT (API) MANUFACTURED
16. WHAT IS AN ACTIVE PHARMACEUTICAL INGREDIENT (API)
17. EXCIPIENTS AND ACTIVE PHARMACEUTICAL INGREDIENTS
18. GOOD MANUFACTURING PRACTICE FOR ACTIVE
PHARMACEUTICAL INGREDIENTS
19. ACTIVE PHARMACEUTICAL INGREDIENT (API) CHEMICALS
20. LIST OF IDENTIFIED PRODUCTS FOR PRODUCTION LINKED
INCENTIVE (PLI) SCHEME
21. ACEBUTOLOL
22. ACETAZOLAMIDE
23. ALLOPURINOL
24. AMPHETAMINE PHOSPHATE
25. APALCILLIN SODIUM
26. BACITRACIN
27. BECLAMIDE
28. BENFURODIL HEMISUCCINATE
29. BROMOPRIDE
30. BUMADIZON

31. CAMAZEPAM
32. CARBINOXAMINE MALEATE
33. CEPHALOGLYCIN
34. CLINDAMYCIN HYDROCHLORIDE
35. CLOFIBRATE
36. CYCLOPENTAMINE HYDROCHLORIDE
37. DACTINOMYCIN
38. DACTINOMYCIN
39. DIAZEPAM
40. DOXEPIN HYDROCHLORIDE
41. DYDROGESTERONE
42. EDROPHONIUM CHLORIDE
43. ENDRALAZINE
44. EPICILLIN
45. EPIRIZOLE
46. ERYTHROMYCIN
47. FAZIDINIUM BROMIDE
48. FELYPRESSIN
49. FLUBENDAZOLE
50. FLUNITRAZEPAM
51. FURALTADONE
52. GALLAMINE TRIETHIODIDE
53. GENTAMICIN SULFATE

54. GLYMIDINE
55. GRAMICIDIN
56. GUANFACINE
57. HALOPERIDOL
58. HEPARIN
59. HOMOFENAZINE
60. HYDROCHLOROTHIAZIDE
61. HYDROXYSTILBAMIDINE ISETHIONATE
62. IBUPROFEN
63. IDOXURIDINE
64. IFENPRODIL TARTRATE
65. INDENOLOL
66. IODAMIDE
67. KANAMYCIN SULFATE
68. KEBUZONE
69. KETOTIFEN
70. LACTULOSE
71. LEVODOPA
72. LIDOCAINE
73. LOPERAMIDE HYDROCHLORIDE
74. LOXAPINE
75. MANNITOL
76. MELPHALAN

77. METYRAPONE
78. MIDECAMYCIN
79. MOTRETINIDE
80. MUZOLIMINE
81. NALOXONE
82. NEFOPAM HYDROCHLORIDE
83. NIAPRAZINE
84. NIMETAZEPAM
85. NOXIPTILIN
86. OCTOPAMINE HYDROCHLORIDE
87. OLEANDOMYCIN
88. ORGOTEIN
89. OXACILLIN SODIUM
90. OXACEPROL
91. PAPAIN
92. PENICILLIN G BENZATHINE
93. PHENAGLYCODOL
94. PICOPERINE
95. POLYESTRADIOL PHOSPHATE
96. PYRIDINOL CARBAMATE
97. QUINESTROL
98. QUINETHAZONE
99. QUINIDINE POLYGALACTURONATE

100. QUINUPRAMINE
101. RANITIDINE
102. RESCINNAMINE
103. RIMITEROL
104. RITODRINE
105. ROSOXACIN
106. SALICYLIC ACID
107. SECOBARBITAL SODIUM
108. SINCALIDE
109. STREPTOKINASE
110. SULFACYTINE
111. TALAMPICILLIN
112. TESTOLACTONE
113. THIAMPHENICOL
114. TICRYNAFEN
115. TOCAINIDE
116. UBIDECARENONE
117. URACIL MUSTARD
118. URAPIDIL
119. UROKINASE
120. VANCOMYCIN
121. VERAPAMIL
122. VIDARABINE

123. VILOXAZINE HYDROCHLORIDE
124. VIMINOL
125. VINBLASTINE SULFATE
126. WARFARIN SODIUM
127. XANTHINOL NIACINATE
128. XIBORNOL
129. XIPAMID
130. XYLOMETAZOLINE HYDROCHLORIDE
131. ZERANOL
132. ZIMELIDINE
133. ZIPEPROL
134. ZOMEPIRAC
135. ZOTEPINE
136. ZOXAZOLAMINE
137. PACKAGING OF PHARMACEUTICAL PRODUCTS
138. BIS STANDARDS
139. ISO STANDARDS
140. PLANT LAYOUT AND PROCESS FLOW CHART & DIAGRAM
141. PHOTOGRAPHS OF PLANT AND MACHINERY WITH
SUPPLIER’S CONTACT DETAILS

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#Ingredients, #API, #Drugs, #Products, #Paracetamol,
#Aspirin, #Ivfluids, #Ointment, #Metronidazole,
#Liquidglucose, #Surgical, #Cotton, #Syrup, #Tablet,
#Excipients, #Pharmaceuticalsalts,
#Manufacturingprocess, #Factorylayout, #Newbook,
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#Apimanufacturing, #Pharmaindustry, #Medical,
#Medicine, #Medicalproduct

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