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1 st  International Conference on Innovative Growth for Pharmaceutical and Medical Industry in Russia. Integrating Academic and Industrial Science MIPT, 12 May 2011 Henrik A. E. Konarkowski   ChemRar High Tech Center www.chemrar.ru
[object Object],[object Object],[object Object],[object Object],THE COST OF A DELAY DAY (SELECT BLOCKBUSTER DRUGS) Note: The average drug generates $1.3 million sales daily Source: IMS Health, 2002 and PhRMA Profile, March 2007 The Cost of Developing a Drug
DISTRIBUTION OF BIG PHARMA R&D SPENDING Source: PhRMA Annual Survey, 2006
 
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[object Object],[object Object],Or Accessing ,[object Object]
Source: Contract Pharma Second Annual Outsourcing Survey, 2006
      Price Trust Independence Collaboration ,[object Object],[object Object],Source: Modified from Price Waterhouse Coopers Am.Pharm.Outsourcing 6,01:30-32 and J. Wilmer, Prime Trials  Outsourcing Clinical Trials CRO Perspective , 2004 Value Ordering Tactical Outsourcing Strategic OutPartnering Insourcing Catalogue / Menu Fee for Service Preferred Fee for Service Partner Collaboration Alliance Localized Integration
[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
Completion of the required data package  paid for by time used
i.e. special Chemistry on Demand
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Hit series Lead series Leads Clinical Candidates 2 year FHD POC « We are very happy to consolidate a portion of our external research activities that are currently being outsourced to several different contract research organizations as this we believe will shorten development timeline. Moreover we are pleased to have found a partner that shares our business model approach »  Frédéric Cren,   Head of Research at Solvay Pharmaceuticals 4 year
Clinical Candidate FHD POC PII PIII NDA
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Передача лицензии на территорию России Проведение доклиники или  клиники в  РФ Производство инновационного препарата в РФ Передача  результатов клинических исследований Коммерциализация за рубежом Руб. Кросс-Роялти % Финансирование  От Российских партнеров Модель трансферта разработок инновационных   лекарственных средств $$$ Иностранный партнер Российский партнер Иностранный партнер Российский партнер
[object Object],[object Object],Or Accessing
[object Object],[object Object],Or Accessing ,[object Object]
CSC starts chemistry servies in Russia CHEMRAR incorporat. New Research Institute in Khimki, Moscow licensed 1st Russian Patent in liquid crystal technology to  Hoffmann La Roche, Basel Formulation, Pilot GMP, API with MIT support The first LP in Western VC incorporation CITOLEX – first manufacturing project in RUSSIA ID - first biotech in Yaroslavl Univ. with Federal Innov. agency support Clinical Research Organization Health Care Ventures IX The first IP transfer project with ROCHE The first biotech in USA JV with RUSNANO  ($160M venture project) Active partnering with few Life Science Venture funds 84 90 95 00 05 07 08 09 10 Open labs in San Diego CA New wave as RVC partner 11 04
From 2008 ChemRar experts prominently participated in drafting of  the “Russian Federation Innovative Development Strategy for the Pharmaceutical Industry through the year  2020” (Pharma2020).  December ,  2010: Prime Minister Vladimir Putin visiting ChemRar with Ministers of Industy and Health
Bringing into Russia innovative development projects at various stages, from Biotarget stage,  to clinical candidates, and developing them into Medicines In-Partnering Development Projects Globally 20 years, more than 1200 partners
first line Service Research  Organizations Biotech Companies Manufacturing & Market Access
Partnering with Russia’s Scientific Institutions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],7 programs funded  8 in various funding  stages 15 programs suggested  for funding 250k to 2.5M for seed 5-30M for development 65 programs selected  for evaluation 200 partners identified 2007-2009
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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H.A.E.Konarowski, Chemrar High-Teck Center

  • 1. 1 st International Conference on Innovative Growth for Pharmaceutical and Medical Industry in Russia. Integrating Academic and Industrial Science MIPT, 12 May 2011 Henrik A. E. Konarkowski ChemRar High Tech Center www.chemrar.ru
  • 2.
  • 3. DISTRIBUTION OF BIG PHARMA R&D SPENDING Source: PhRMA Annual Survey, 2006
  • 4.  
  • 5.
  • 6.
  • 7. Source: Contract Pharma Second Annual Outsourcing Survey, 2006
  • 8.
  • 9.
  • 10.  
  • 11.
  • 12.
  • 13. Completion of the required data package paid for by time used
  • 15.
  • 16.
  • 17.
  • 18. Clinical Candidate FHD POC PII PIII NDA
  • 19.
  • 20. Передача лицензии на территорию России Проведение доклиники или клиники в РФ Производство инновационного препарата в РФ Передача результатов клинических исследований Коммерциализация за рубежом Руб. Кросс-Роялти % Финансирование От Российских партнеров Модель трансферта разработок инновационных лекарственных средств $$$ Иностранный партнер Российский партнер Иностранный партнер Российский партнер
  • 21.
  • 22.
  • 23. CSC starts chemistry servies in Russia CHEMRAR incorporat. New Research Institute in Khimki, Moscow licensed 1st Russian Patent in liquid crystal technology to Hoffmann La Roche, Basel Formulation, Pilot GMP, API with MIT support The first LP in Western VC incorporation CITOLEX – first manufacturing project in RUSSIA ID - first biotech in Yaroslavl Univ. with Federal Innov. agency support Clinical Research Organization Health Care Ventures IX The first IP transfer project with ROCHE The first biotech in USA JV with RUSNANO ($160M venture project) Active partnering with few Life Science Venture funds 84 90 95 00 05 07 08 09 10 Open labs in San Diego CA New wave as RVC partner 11 04
  • 24. From 2008 ChemRar experts prominently participated in drafting of the “Russian Federation Innovative Development Strategy for the Pharmaceutical Industry through the year 2020” (Pharma2020). December , 2010: Prime Minister Vladimir Putin visiting ChemRar with Ministers of Industy and Health
  • 25. Bringing into Russia innovative development projects at various stages, from Biotarget stage, to clinical candidates, and developing them into Medicines In-Partnering Development Projects Globally 20 years, more than 1200 partners
  • 26. first line Service Research Organizations Biotech Companies Manufacturing & Market Access
  • 27.
  • 28.
  • 29.