Mbis Presentation University


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MassCONNECT program benefits academic medical centers and universities

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Mbis Presentation University

  1. 1. Mass CONNECT Leveraging industry networks to advance translational research
  2. 2. The goal of translational medicine… Industry AMC/Univ Bench Bedside Bench Late-preclinical & Preclinical dev Clinical development Clinical trials Bedside
  3. 3. Pharma’s predicament 10 20 30 40 50 60 40 30 20 10 1995 2000 2005 50 NMEs and Biologics Approved R&D Spending (US$ Billions) R&D expenditures Approvals Sources: FDA/CDER, PhRMA, PricewaterhouseCoopers Note: R&D spending from non-PhRMA companies not available Courtesy of Ted Torphy, JNJ presented at Massbio Pharma Days
  4. 4. Translating research to products Value $ Invention = data, tools, IP, Know-How RO1 funding enabled research “ Applied” research Basic research Research progress Phase II-Proof of concept Proof of principle FIM Animal disease model Translation gap
  5. 5. But the goal is impeded by translation gap! <ul><li>Translation Gap </li></ul><ul><li>Inability to effectively convert accomplishments achieved in the academic labs to the parlance of early stage pipeline opportunity </li></ul><ul><li>Poor networks of expertise, funding, and industry leadership </li></ul><ul><li>impedes transfer of value between academia and biotech/pharma </li></ul>Discovery work Industrialization Commercial-ization Value $ Time Mass CONNECT Translation Gap
  6. 6. Leveraging the industry accelerates the right opportunities <ul><ul><li>Build a cross-disciplinary group of advisors and mentors </li></ul></ul><ul><ul><ul><li>provide tutoring and advice to diminish obstacles which derail promising early-stage technology prior to commercialization </li></ul></ul></ul><ul><ul><li>Rapidly screen technology to identify the most promising candidates </li></ul></ul><ul><ul><li>Connect proven industry navigators & advisors </li></ul></ul>
  7. 7. What’s in it for you…power of distributive tasking <ul><li>Using seasoned industry professionals to sift through and prioritize opportunities of value </li></ul><ul><li>Helps you prioritize opportunities with greatest likelihood of success </li></ul><ul><li>Capitalize on the industry network to target the parties most interested in licensing </li></ul><ul><li>Increase the throughput of technology out of your office </li></ul>Distributive tasking from industry professionals allows more opportunities to be examined, sorted and prioritized
  8. 8. Accelerating the right opportunities Technology Scouting Innovator Services Products and Startups + = Sources of Innovation MassCONNECT Products & Startups Partnerships with Industry <ul><li>Technology identification </li></ul><ul><li>Investigator relationships </li></ul><ul><li>Technology aggregation </li></ul><ul><li>Proof-of-concept development </li></ul><ul><li>Bridging the valley of death </li></ul><ul><li>Disciplined due diligence </li></ul><ul><li>Turn science into products </li></ul><ul><li>Commercially viable products to… </li></ul><ul><li>Fill bio/pharma pipelines </li></ul><ul><li>Conduct clinical trials </li></ul><ul><li>Catalyze startups </li></ul><ul><li>Mentorship/Networking </li></ul><ul><li>EIR program </li></ul><ul><li>Workshops/training </li></ul><ul><li>Sector experts </li></ul><ul><li>Due diligence </li></ul><ul><li>Grants/matching funds </li></ul>
  9. 9. Ideal investigator profile for MassCONNECT <ul><li>Entrepreneurial </li></ul><ul><li>Visionary </li></ul><ul><li>Collaborative </li></ul><ul><li>“ Next gen” </li></ul><ul><li>Exciting ideas </li></ul><ul><li>Lacking industry relationships </li></ul>
  10. 10. “ Quick and dirty” guide to attracting investors <ul><li>Technical POC that is differentiated </li></ul><ul><ul><li>In-vivo data (animal model) </li></ul></ul><ul><ul><ul><li>Have the animal model's data been repeated? </li></ul></ul></ul><ul><li>Patents are available for exclusive licenses </li></ul><ul><li>Publication in a peer reviewed technology journal </li></ul><ul><ul><li>Publications in strong journals </li></ul></ul><ul><ul><ul><li>ideal but not necessary </li></ul></ul></ul><ul><li>Ability for platform development--->multiple targest (Dx or Thx) </li></ul><ul><ul><li>If not..., then: </li></ul></ul><ul><ul><ul><li>option 1: more likely to outlicense to big pharma or biotech </li></ul></ul></ul><ul><ul><ul><li>option 2: get grant $ to show platform POC for 2nd target </li></ul></ul></ul><ul><li>Validation from Industry experts regarding: </li></ul><ul><ul><li>promise/importance of technology </li></ul></ul><ul><ul><ul><li>supported by diligence with KOL </li></ul></ul></ul><ul><li>Who could eat your lunch </li></ul><ul><ul><li>Evaluate 2-3 competing technologies, and provide an answer as to why yours is different </li></ul></ul><ul><ul><li>Reasons to believe viability </li></ul></ul>
  11. 11. “ Quick and dirty” guide to attract pharma Secret Sauce to attracting pharma? <ul><li>Anything that pulls risk forward! </li></ul><ul><li>Molecules (Thx/Dx) </li></ul><ul><li>Validated </li></ul><ul><ul><li>Tools </li></ul></ul><ul><ul><ul><li>Biomarkers! </li></ul></ul></ul><ul><ul><ul><li>Mice, cell based assays </li></ul></ul></ul><ul><ul><ul><li>Abs, model molecules </li></ul></ul></ul><ul><ul><ul><li>Predictive disease models </li></ul></ul></ul>
  12. 12. Accelerating proof-of-concept to partnerships
  13. 13. MassCONNECT Value Proposition <ul><li>Demystify the translation gap </li></ul><ul><ul><li>Reveal where the gaps are and how to fill them </li></ul></ul><ul><ul><ul><li>Proof-of-concept studies </li></ul></ul></ul><ul><ul><ul><li>Understand market (patient) needs </li></ul></ul></ul><ul><ul><ul><li>Hurdles to commercialization  de-risking opportunities </li></ul></ul></ul><ul><li>Create high value linkage to industry </li></ul><ul><ul><li>Bio/pharma networks </li></ul></ul><ul><ul><li>VC and other funding networks </li></ul></ul><ul><li>Accelerate a value stream for your technology </li></ul><ul><ul><li>Better licenses </li></ul></ul><ul><ul><li>Potential start-up </li></ul></ul>
  14. 14. MassCONNECT delivers to you presentation Non-profit VC Development Corp Corp Lic Return to Academia 1-2x Improve <ul><li>Evaluation of business proposal </li></ul><ul><li>Business advisors work with investigators to coach </li></ul><ul><li>Concise business plan developed (by MBAs) </li></ul><ul><li>Office Hours </li></ul><ul><li>VCs- real time feedback </li></ul><ul><li>MassBio – BD&L </li></ul><ul><li>Creation of industry network </li></ul><ul><li>Introduction to funding network </li></ul><ul><li>In hand: </li></ul><ul><li>Refined business pitch deck </li></ul><ul><li>Understanding of business model </li></ul><ul><li>Strategy and operations delineated </li></ul><ul><li>Mentor network resource </li></ul><ul><li>Screening of technology </li></ul><ul><li>Industry feedback on strengths, weaknesses, opportunity, threats </li></ul><ul><li>Free participation in MassBio Programs </li></ul><ul><li>Entrepreneur’s University </li></ul><ul><li>BD Committee Meetings </li></ul><ul><li>Finance Committee Meetings </li></ul><ul><li>One-to-one consultation with industry expert </li></ul>Submission Evaluation Refinement Output
  15. 15. Pharma Days Building productive partnerships <ul><li>Industry sourcing strategy revealed </li></ul><ul><li>One-on-one partnering with heads of business development at major bio/pharma </li></ul><ul><li>Intimate and unhurried exchange of information. </li></ul><ul><ul><li>Obviate the frenzy and “noise” of other major partnering conferences </li></ul></ul><ul><li>A one to two day unique partnering event. </li></ul><ul><ul><li>Visibility + Accessability = Possibility </li></ul></ul>Best of all, Pharma Days is right here in Cambridge! No need to travel, take time out of your offices, or waste time trying to find a time to meet. MassCONNECT MassBio Innovation Exchange Pharma Days Investors Forum Innovators’ Roundtable
  16. 16. MassBio Innovation Exchange <ul><li>Web 2.0 open innovation platform </li></ul><ul><ul><li>connects solutions to problems </li></ul></ul><ul><li>Couples technology and the networking power of MassBio </li></ul><ul><li>Tailors technology disclosures to industry “spec” </li></ul><ul><li>Communication channel for accessed technology </li></ul>
  17. 18. You are cordially invited to apply for participation in MassCONNECT.   http://www.massbio.org/membership/massconnect Deadline April 16 th , 2010 Have questions? Contact Imran Nasrullah, Chief Business Officer at MassBio, at 617-674-5151.
  18. 19. Back up slides
  19. 20. Sustaining growth – Wall Street’s <ul><ul><li>Consider Lipitor, in mid year 2008, its global sales were $12B </li></ul></ul><ul><ul><ul><li>Next year’s return needs to be $1.2B </li></ul></ul></ul><ul><ul><ul><li>A new product needs to bring in $1.2B to keep EPS up! </li></ul></ul></ul>
  20. 21. Generally, limited resources hampers your effectiveness Limted budgets Staff:Disclosure ratio is small Investigator pressure Limited resources for due diligence Sifting for valuable disclosures Opportunities Disclosed Opportunities <ul><li>Limited throughput </li></ul><ul><li>Lower value licenses </li></ul><ul><li>Longer negotiation times </li></ul>
  21. 22. Innovators Roundtables Solutions-based dialogue with leaders in industry and stakeholders <ul><li>Exclusive roundtable discussions with leading academicians, CEOs, R&D heads, angel investors, venture capitalists. </li></ul><ul><li>The objective: define a set of initiatives, where participants can, directly or through influence, bring the necessary funding to bear to assure that those early stage innovations with the highest potential continue to the clinic, enrich pipelines and improve options for patients. </li></ul><ul><li>  </li></ul><ul><li>To devise better collaborative models to expedite translational therapeutics. </li></ul>MassCONNECT MassBio Innovation Exchange Pharma Days Investor Forum Innovators’ Roundtable
  22. 23. MassCONNECT Process presentation Non-profit VC Development Corp Corp Lic Return to Academia 1-2x Improve <ul><li>Business advisory services </li></ul><ul><li>MassBio Programs </li></ul><ul><li>Office Hours </li></ul><ul><li>VCs </li></ul><ul><li>MassBio – BD&L </li></ul><ul><li>One-to-one consultation </li></ul><ul><li>Network of funding sources: </li></ul><ul><li>VCs </li></ul><ul><li>Drug development </li></ul><ul><li>Business plan competition </li></ul><ul><li>One-to-one consultation </li></ul><ul><li>MassBio Programs </li></ul><ul><li>Entrepreneur’s University </li></ul><ul><li>BD Committee Meetings </li></ul><ul><li>Finance Committee Meetings </li></ul><ul><li>Education Foundation Courses </li></ul>Submission Evaluation Refinement Output