This document provides guidance for submitting proposals to Colombia CO4, a collaborative innovation program. It summarizes what collaborative innovation entails, including identifying challenges, finding external solutions, and generating new relationships. It then outlines the program, including the 11 challenge holding companies, how solutions will be selected, and the roles of iNNpulsa and SENA in facilitating partnerships between companies and solvers. Key terms like "solver," "challenge," and "stages" are also defined in a glossary section.