Breakout: Growing Up with Ovarian Cancer: facing the Battle as a Young Adult: Rebecca Block, PhD
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The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
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In the Know About Recurrence, Sarah Adams, MD
The document discusses recurrent ovarian cancer. It notes that the chances of recurrence vary based on initial stage, with stage III having the highest risk. Symptoms of recurrence can include abdominal bloating or pain. Recurrence is typically diagnosed through physical exam, rising CA125 levels, or imaging. Treatment depends on platinum sensitivity, and may include surgery, chemotherapy, targeted therapies, or clinical trials. One study found that initiating treatment based on rising CA125 levels alone improved progression-free and overall survival compared to waiting for symptoms.
Case Report:Massive Ovarian Cyst in a Adolescent Girl
For benign tumours adhesion prevention strategies should be used. Surgical intervention should as much as possible be directed towards preservation of ovarian tissue. There is scarcity of published literature on this subject.
We need bigger studies to address the issue of how much fertility preservation is safely possible.Irrespective of indication for surgery, it is always preferable to attempt conservative, fertility sparing surgery in adolescents.
Dermoid Ovarian Cysts By The Numbers - Things You Should Know
Dermoid ovarian cysts, also called ovarian teratomas or monster cysts, are a type of cysts on ovary. They can sometimes contain hair, blood, thyroid tissues, bones, eyes and many other fully developed organ strutures. They are also prone to causing the twisting of the ovaries (ovarian torsion). Understanding them is therefore important if you want to get rid of them, prevent them or simply manage some of the ovarian cyst symptoms that they sometimes cause. Here are numbers that can help to shed light on dermoid cysts - mature cystic teratomas
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This document discusses genetic counseling for cancer risk assessment. It begins with an introduction to Sandra Brown and her role as manager of the Cancer Genetics Program. It then provides information on various genes associated with cancer risks and how damage to these genes can cause uncontrolled growth and malignant tumors. The rest of the document discusses the differences between sporadic, familial, and inherited cancers; the process of genetic counseling before and after genetic testing; recommendations for who should receive genetic counseling; challenges like interpreting results and informing family; and current issues and controversies in cancer genetics.
Dermoid Cyst
This document summarizes and differentiates between various types of cysts: dermoid cysts, which are lined with squamous epithelium; teratomatous cysts; sequestration cysts; implantation cysts; branchial cysts in the neck; cystic hygromas in the neck; sebaceous cysts; sinuses and fistulas. It notes the locations, patient demographics, clinical features, diagnostic tools, and treatments for each type of cyst.
Ovarian cyst(gynec)
Ovarian cysts are fluid-filled sacs that develop on the ovaries. Most cysts are benign and functional, related to the menstrual cycle. They cause no symptoms and resolve on their own. Ultrasound is used to diagnose cysts based on size, contents, and appearance. Small, asymptomatic cysts may simply be monitored while larger or symptomatic cysts may require surgery.
ovarian tumor
The document provides an overview of epithelial ovarian tumours, which make up 90% of ovarian tumours. They most commonly originate from the coelomic epithelium. The four main histological types are serous, mucinous, endometrioid, and clear cell. Risk factors include increased age, family history, and lack of pregnancy. Screening and tumor markers like CA125 are used for early detection but have limitations. Surgery is the main treatment and chemotherapy is used for advanced stages. Prognosis depends on stage, with 5-year survival rates ranging from 76-93% for stage 1 to 11% for stage 4.
Dermoid cyst
Dermoid cysts are cysts lined with squamous epithelium that contain skin adnexa such as sweat glands, sebaceous glands, and hair follicles. There are several types of dermoid cysts including congenital dermoid cysts that form along embryonic fusion lines and can cause bony defects, implantation dermoid cysts that form after skin implantation injuries, and teratomatous dermoid cysts containing tissues from all germ layers. Dermoid cysts typically present as slow-growing, painless swellings and are diagnosed based on location and imaging findings showing cystic masses sometimes eroding adjacent bone. Excision is the treatment.
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In the Know About Recurrence, Sarah Adams, MD
The document discusses recurrent ovarian cancer. It notes that the chances of recurrence vary based on initial stage, with stage III having the highest risk. Symptoms of recurrence can include abdominal bloating or pain. Recurrence is typically diagnosed through physical exam, rising CA125 levels, or imaging. Treatment depends on platinum sensitivity, and may include surgery, chemotherapy, targeted therapies, or clinical trials. One study found that initiating treatment based on rising CA125 levels alone improved progression-free and overall survival compared to waiting for symptoms.
Case Report:Massive Ovarian Cyst in a Adolescent Girl
For benign tumours adhesion prevention strategies should be used. Surgical intervention should as much as possible be directed towards preservation of ovarian tissue. There is scarcity of published literature on this subject.
We need bigger studies to address the issue of how much fertility preservation is safely possible.Irrespective of indication for surgery, it is always preferable to attempt conservative, fertility sparing surgery in adolescents.
Dermoid Ovarian Cysts By The Numbers - Things You Should Know
Dermoid ovarian cysts, also called ovarian teratomas or monster cysts, are a type of cysts on ovary. They can sometimes contain hair, blood, thyroid tissues, bones, eyes and many other fully developed organ strutures. They are also prone to causing the twisting of the ovaries (ovarian torsion). Understanding them is therefore important if you want to get rid of them, prevent them or simply manage some of the ovarian cyst symptoms that they sometimes cause. Here are numbers that can help to shed light on dermoid cysts - mature cystic teratomas
Genetics 101: Sandra Brown, MS, LCGC
This document discusses genetic counseling for cancer risk assessment. It begins with an introduction to Sandra Brown and her role as manager of the Cancer Genetics Program. It then provides information on various genes associated with cancer risks and how damage to these genes can cause uncontrolled growth and malignant tumors. The rest of the document discusses the differences between sporadic, familial, and inherited cancers; the process of genetic counseling before and after genetic testing; recommendations for who should receive genetic counseling; challenges like interpreting results and informing family; and current issues and controversies in cancer genetics.
Dermoid Cyst
This document summarizes and differentiates between various types of cysts: dermoid cysts, which are lined with squamous epithelium; teratomatous cysts; sequestration cysts; implantation cysts; branchial cysts in the neck; cystic hygromas in the neck; sebaceous cysts; sinuses and fistulas. It notes the locations, patient demographics, clinical features, diagnostic tools, and treatments for each type of cyst.
Ovarian cyst(gynec)
Ovarian cysts are fluid-filled sacs that develop on the ovaries. Most cysts are benign and functional, related to the menstrual cycle. They cause no symptoms and resolve on their own. Ultrasound is used to diagnose cysts based on size, contents, and appearance. Small, asymptomatic cysts may simply be monitored while larger or symptomatic cysts may require surgery.
ovarian tumor
The document provides an overview of epithelial ovarian tumours, which make up 90% of ovarian tumours. They most commonly originate from the coelomic epithelium. The four main histological types are serous, mucinous, endometrioid, and clear cell. Risk factors include increased age, family history, and lack of pregnancy. Screening and tumor markers like CA125 are used for early detection but have limitations. Surgery is the main treatment and chemotherapy is used for advanced stages. Prognosis depends on stage, with 5-year survival rates ranging from 76-93% for stage 1 to 11% for stage 4.
Dermoid cyst
Dermoid cysts are cysts lined with squamous epithelium that contain skin adnexa such as sweat glands, sebaceous glands, and hair follicles. There are several types of dermoid cysts including congenital dermoid cysts that form along embryonic fusion lines and can cause bony defects, implantation dermoid cysts that form after skin implantation injuries, and teratomatous dermoid cysts containing tissues from all germ layers. Dermoid cysts typically present as slow-growing, painless swellings and are diagnosed based on location and imaging findings showing cystic masses sometimes eroding adjacent bone. Excision is the treatment.
Classification of ovarian tumors
This document provides information on ovarian tumors, including normal ovarian anatomy and function, differential diagnosis of adnexal masses, classification of ovarian neoplasms, clinical presentation, evaluation, and management of ovarian cysts and masses. Key points include:
- Ovarian cysts are a common finding and are usually benign functional cysts.
- Evaluation involves ultrasound, tumor markers like CA-125 and HE4, and risk of malignancy algorithms.
- Management depends on factors like size, symptoms, and patient age/menopausal status.
- Ovarian neoplasms include functional, inflammatory, and neoplastic tumors and are classified based on histology.
- Borderline ovarian tumors have
Ovarian cysts
Ovarian cysts are sacs filled with liquid or semi-liquid material that arise in the ovaries. The majority are benign and not cancerous. There are several types of ovarian cysts including functional cysts (follicular, corpus luteum, and theca lutein cysts), endometriomas, and polycystic ovarian syndrome. Ovarian cysts may cause lower abdominal pain but many are asymptomatic. Ultrasound is used to examine cyst features and size while blood tests and further imaging can help determine if a cyst is benign or potentially cancerous. Most small, simple cysts can be monitored but larger or complex cysts may require surgical removal. The prognosis for benign ovarian cysts is
Ovarian cancer
a nice presentation about the Ovarian Cancer its include an introduction with brief notes about the epidemiology and risk factors then shift to pathology and pathogenesis and diagnosis with signs , symptoms and lab tests with imaging modules , screening , management
Ovarian cancer
This document provides background information on ovarian cancer, including its pathophysiology, etiology, epidemiology, clinical presentation, diagnosis, and screening. It states that ovarian cancer typically spreads within the peritoneal cavity. Several risk factors are identified, including genetic and reproductive factors. Epithelial ovarian cancer represents the most common histology and has a poor prognosis when diagnosed at advanced stages, due to nonspecific symptoms. No approved screening methods exist for ovarian cancer detection.
Nursing diagnosis
This document discusses nursing diagnosis, including its evolution, purpose, definition, components, types, prioritization, case studies, errors to avoid, limitations, and overcoming barriers. Specifically, it outlines how nursing diagnosis evolved from Fry's identification in 1953 as a tool for individualized care to NANDA developing new diagnoses in 1998. The purpose is to identify areas nurses can resolve, demonstrate professional judgment, and promote accountability. A nursing diagnosis is a clinical judgment about an individual's response to health problems.
Benign ovarian tumours
This document discusses the diagnosis and management of adnexal masses. It provides information on the normal size and variation of ovaries and lifetime risk of ovarian neoplasms. Differential diagnoses of adnexal masses are outlined based on patient age. Diagnostic evaluation includes physical exam, ultrasound, CT or MRI if needed. Common ovarian tumors at different life stages are described. Functional cysts, endometriomas, benign and borderline tumors are discussed. Complications, clinical presentation, imaging and tumor markers are summarized. Guidelines for management of asymptomatic cysts and indications for surgery are provided.
Ovarian cancer ppt
This document provides an overview of ovarian cancer, including:
1. The different types of ovarian tumors that can develop from the epithelial, germ, and stromal cells in the ovaries.
2. The symptoms of ovarian cancer, which can include pelvic pain, back pain, indigestion, and frequent urination.
3. Causes of ovarian cancer such as family history, age, number of ovulations, and genetic syndromes.
4. Stages of ovarian cancer from Stage 1 through Stage 4.
Ovarian Cancer
- Ovarian cancer is the 5th most common cancer in women and the most common cause of gynecologic mortality, with an estimated 21,650 new cases and 15,520 deaths in the US in 2008.
- Risk factors include advancing age, infertility, endometriosis, talcum powder use, and genetic susceptibility. Protective factors include oral contraceptive use, parity, and tubal sterilization.
- Screening with transvaginal ultrasound and CA125 is recommended for high-risk women like those with BRCA mutations, but routine screening is not recommended for the general population due to low sensitivity of tests for early detection.
Nursing care plans
The document provides information about various eye, throat, and immune system problems, as well as musculoskeletal problems. For each system, specific disorders are enumerated and described. One problem from each system is then selected and a nursing care plan is provided using the nursing diagnosis, objectives of care, nursing interventions, and rationale format. The care plan example provided is for a patient with glaucoma involving the eyes, pharyngitis involving the throat, lupus erythematosus involving the immune system, and a herniated disk involving the musculoskeletal system.
Sex and Cancer, Jeanne Carter, PhD
Disclaimer: These slides belong to Dr. Jeanne Carter and cannot be reproduced without her explicit consent.
Presented July 10, 2016 at the Ovarian Cancer National Conference in Washington, DC
Genetics: Beyond BRCA, Reem Saadeh-Haddad, MD
This document discusses cancer risks associated with hereditary cancer syndromes like BRCA1/2 mutations and HNPCC. It provides lifetime risk percentages for various cancers in mutation carriers compared to the general population. It describes screening and prevention strategies like surveillance, chemoprevention, and prophylactic surgery that can reduce cancer risk. Genetic testing considerations and the importance of informing at-risk relatives is also covered.
Genetics: Beyond BRCA, Ursula Matulonis, MD
1) PARP inhibitors work by preventing DNA repair in cancer cells with underlying DNA repair deficiencies like BRCA mutations, making them more susceptible to cell death.
2) Clinical trials show PARP inhibitors like olaparib and niraparib increase time to progression in platinum-sensitive ovarian cancer, including in patients without BRCA mutations.
3) Combining PARP inhibitors with other agents like angiogenesis inhibitors or immunotherapy may increase their effectiveness in additional patient subgroups.
Growing up with Ovarian Cancer: Facing the Battle as a Young Adult, Julie Lar...
Growing up with Ovarian Cancer: Facing the Battle as a Young Adult, Julie Lar...Ovarian Cancer Research Fund Alliance
This document discusses the developmental challenges faced by young adult cancer survivors. It begins by defining the adolescent and young adult (AYA) population and reviewing developmental theories relevant to AYAs. It then outlines key developmental tasks of AYAs, such as establishing independence and developing relationships. The document also examines the emotional needs of AYA cancer survivors and the psychological issues they may face due to the demands of cancer and its impact on normal development. It emphasizes the importance of resilience and provides strategies for AYA cancer survivors to build resilience through self-care, coping skills, and social support.Expert Roundtable, Michael Seiden, MD, PhD
This document discusses ovarian cancer research and clinical trials. It provides an overview of ovarian cancer subtypes and gene mutations associated with serous cancer. It also summarizes various drug targets and clinical trials being studied for ovarian cancer treatment, including PARP inhibitors, Akt inhibitors, angiogenesis inhibitors, monoclonal antibodies, immune therapies, vaccines, and CAR-T cells. Challenges in ovarian cancer research like intra-tumor variability and the complexity of genetics are discussed. The importance of patient participation in clinical trials to advance scientific progress is emphasized.
Newly Diagnosed, Stephanie Wethington, MD
This document outlines the process from diagnosis to follow-up care for ovarian cancer. It begins with an introduction and disclosure section. It then covers the diagnosis process, including symptoms, imaging, biopsy and surgery. Treatment options like surgery, chemotherapy, targeted therapy and clinical trials are discussed. The roles of the treatment team members are defined. Follow-up care including exams, imaging and survivorship are also summarized. Resources and questions from patients are addressed. Key terminology around histology, grade, stage and tumor markers is explained.
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This document summarizes a presentation on recurrent ovarian cancer given by Dr. Sarah Adams. It discusses the likelihood of recurrence based on initial cancer stage, common symptoms of recurrence, methods for diagnosing recurrence including physical exam, CA125 levels, and imaging, and treatment options based on platinum sensitivity including surgery, chemotherapy regimens, targeted therapies, and clinical trials. It also describes a 2010 European study that found initiating treatment earlier based on a CA125 doubling led to longer treatment-free intervals and improved overall survival compared to delayed treatment until symptom recurrence.
Mello Abrams Lecture: Research in Ovarian Cancer, Where Are We Now?, Michael ...
Mello Abrams Lecture: Research in Ovarian Cancer, Where Are We Now?, Michael ...Ovarian Cancer Research Fund Alliance
The document discusses improving care for ovarian cancer patients. It outlines the "Triple Aim" of better care, better value, and better outcomes. It describes elements to improve patient care like navigation, survivorship care, and advance care planning. It discusses new payment models that incentivize high quality care while reducing costs, and challenges of implementing value-based care. Finally, it covers recent scientific advances in personalized medicine for ovarian cancer through genetic testing and targeted therapies.Cancer in the Workplace, Ann Hodges
This document summarizes legal protections and obligations for employees with cancer. It discusses the Family and Medical Leave Act (FMLA), Americans with Disabilities Act (ADA), disability benefits from Social Security, private plans, and state programs, health insurance through the Affordable Care Act and COBRA, gaps in coverage, practical strategies, and resources for legal assistance. Key legal protections provide unpaid and job-protected leave under FMLA and prohibit disability discrimination under ADA, which requires reasonable accommodation. However, many employees remain uncovered or face challenges obtaining benefits.
Your Advocacy at Work: The DoD Academy, Elizabeth Poole, PhD
- Mouse models and epidemiological studies suggest a role of chronic stress in tumor progression and cancer risk.
- In ovarian cancer patients, higher levels of stress are associated with higher levels of angiogenic and inflammatory markers, poorer quality of life, and worse survival.
- Data from the Nurses' Health Studies show associations between various measures of stress - like depression, anxiety, social isolation, and widowhood - and increased risk of ovarian cancer. Longer telomere length is associated with decreased risk.
Your Advocacy at Work: The DoD Academy, Karen McLean, MD, PhD
This document summarizes Dr. Karen McLean's research on targeting the tumor microenvironment in ovarian cancer. It discusses how signals from mesenchymal stem cells and estrogen in the microenvironment promote cancer growth and resistance to therapy. Experiments show that blocking the IL-6 and LIF cytokine signals from mesenchymal stem cells, in addition to blocking estrogen signals, significantly reduces cancer cell growth more than targeting either pathway alone. The goal is to identify biomarkers to predict which patients may benefit from anti-estrogen therapies and improve treatment outcomes by blocking multiple promoting signals in the tumor microenvironment.
Clinical Trials: Fact vs. Fiction, Courtney Hudson, CEO & Co-Founder, Emergin...
Clinical Trials: Fact vs. Fiction, Courtney Hudson, CEO & Co-Founder, Emergin...Ovarian Cancer Research Fund Alliance
Clinical trials provide a way to test new cancer therapies and determine their benefits and risks compared to existing standard treatments. This presentation discusses when patients should consider clinical trials, what types of trials are available for ovarian cancer, and key points about targeted therapies and genomic profiling. It notes that clinical trials now mirror the treatment paradigm for ovarian cancer, with trials available at each line of treatment. Over 40 phase 2 and 3 ovarian cancer trials and hundreds of phase 1 solid tumor trials are currently recruiting. Genomic profiling of a patient's tumor may help match them to targeted therapies in clinical trials based on specific molecular alterations.Ovarian Cancer Research and Prevention, Andrew Berchuck, MD
The document discusses recent research on early detection of ovarian cancer, including findings from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Key points include:
- UKCTOCS found that multimodal screening (MMS) using CA125 and ultrasound was more sensitive (86%) than ultrasound alone (63%) for detecting early stage ovarian cancers, and led to fewer unnecessary surgeries.
- Mortality was reduced by 15-28% with MMS compared to no screening over 7-14 years of follow up. MMS also resulted in more cancers being diagnosed at early stages.
- Further analysis of UKCTOCS data is needed to better establish the benefits and
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Classification of ovarian tumors
This document provides information on ovarian tumors, including normal ovarian anatomy and function, differential diagnosis of adnexal masses, classification of ovarian neoplasms, clinical presentation, evaluation, and management of ovarian cysts and masses. Key points include:
- Ovarian cysts are a common finding and are usually benign functional cysts.
- Evaluation involves ultrasound, tumor markers like CA-125 and HE4, and risk of malignancy algorithms.
- Management depends on factors like size, symptoms, and patient age/menopausal status.
- Ovarian neoplasms include functional, inflammatory, and neoplastic tumors and are classified based on histology.
- Borderline ovarian tumors have
Ovarian cysts
Ovarian cysts are sacs filled with liquid or semi-liquid material that arise in the ovaries. The majority are benign and not cancerous. There are several types of ovarian cysts including functional cysts (follicular, corpus luteum, and theca lutein cysts), endometriomas, and polycystic ovarian syndrome. Ovarian cysts may cause lower abdominal pain but many are asymptomatic. Ultrasound is used to examine cyst features and size while blood tests and further imaging can help determine if a cyst is benign or potentially cancerous. Most small, simple cysts can be monitored but larger or complex cysts may require surgical removal. The prognosis for benign ovarian cysts is
Ovarian cancer
a nice presentation about the Ovarian Cancer its include an introduction with brief notes about the epidemiology and risk factors then shift to pathology and pathogenesis and diagnosis with signs , symptoms and lab tests with imaging modules , screening , management
Ovarian cancer
This document provides background information on ovarian cancer, including its pathophysiology, etiology, epidemiology, clinical presentation, diagnosis, and screening. It states that ovarian cancer typically spreads within the peritoneal cavity. Several risk factors are identified, including genetic and reproductive factors. Epithelial ovarian cancer represents the most common histology and has a poor prognosis when diagnosed at advanced stages, due to nonspecific symptoms. No approved screening methods exist for ovarian cancer detection.
Nursing diagnosis
This document discusses nursing diagnosis, including its evolution, purpose, definition, components, types, prioritization, case studies, errors to avoid, limitations, and overcoming barriers. Specifically, it outlines how nursing diagnosis evolved from Fry's identification in 1953 as a tool for individualized care to NANDA developing new diagnoses in 1998. The purpose is to identify areas nurses can resolve, demonstrate professional judgment, and promote accountability. A nursing diagnosis is a clinical judgment about an individual's response to health problems.
Benign ovarian tumours
This document discusses the diagnosis and management of adnexal masses. It provides information on the normal size and variation of ovaries and lifetime risk of ovarian neoplasms. Differential diagnoses of adnexal masses are outlined based on patient age. Diagnostic evaluation includes physical exam, ultrasound, CT or MRI if needed. Common ovarian tumors at different life stages are described. Functional cysts, endometriomas, benign and borderline tumors are discussed. Complications, clinical presentation, imaging and tumor markers are summarized. Guidelines for management of asymptomatic cysts and indications for surgery are provided.
Ovarian cancer ppt
This document provides an overview of ovarian cancer, including:
1. The different types of ovarian tumors that can develop from the epithelial, germ, and stromal cells in the ovaries.
2. The symptoms of ovarian cancer, which can include pelvic pain, back pain, indigestion, and frequent urination.
3. Causes of ovarian cancer such as family history, age, number of ovulations, and genetic syndromes.
4. Stages of ovarian cancer from Stage 1 through Stage 4.
Ovarian Cancer
- Ovarian cancer is the 5th most common cancer in women and the most common cause of gynecologic mortality, with an estimated 21,650 new cases and 15,520 deaths in the US in 2008.
- Risk factors include advancing age, infertility, endometriosis, talcum powder use, and genetic susceptibility. Protective factors include oral contraceptive use, parity, and tubal sterilization.
- Screening with transvaginal ultrasound and CA125 is recommended for high-risk women like those with BRCA mutations, but routine screening is not recommended for the general population due to low sensitivity of tests for early detection.
Nursing care plans
The document provides information about various eye, throat, and immune system problems, as well as musculoskeletal problems. For each system, specific disorders are enumerated and described. One problem from each system is then selected and a nursing care plan is provided using the nursing diagnosis, objectives of care, nursing interventions, and rationale format. The care plan example provided is for a patient with glaucoma involving the eyes, pharyngitis involving the throat, lupus erythematosus involving the immune system, and a herniated disk involving the musculoskeletal system.
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Sex and Cancer, Jeanne Carter, PhD
Disclaimer: These slides belong to Dr. Jeanne Carter and cannot be reproduced without her explicit consent.
Presented July 10, 2016 at the Ovarian Cancer National Conference in Washington, DC
Genetics: Beyond BRCA, Reem Saadeh-Haddad, MD
This document discusses cancer risks associated with hereditary cancer syndromes like BRCA1/2 mutations and HNPCC. It provides lifetime risk percentages for various cancers in mutation carriers compared to the general population. It describes screening and prevention strategies like surveillance, chemoprevention, and prophylactic surgery that can reduce cancer risk. Genetic testing considerations and the importance of informing at-risk relatives is also covered.
Genetics: Beyond BRCA, Ursula Matulonis, MD
1) PARP inhibitors work by preventing DNA repair in cancer cells with underlying DNA repair deficiencies like BRCA mutations, making them more susceptible to cell death.
2) Clinical trials show PARP inhibitors like olaparib and niraparib increase time to progression in platinum-sensitive ovarian cancer, including in patients without BRCA mutations.
3) Combining PARP inhibitors with other agents like angiogenesis inhibitors or immunotherapy may increase their effectiveness in additional patient subgroups.
Growing up with Ovarian Cancer: Facing the Battle as a Young Adult, Julie Lar...
Growing up with Ovarian Cancer: Facing the Battle as a Young Adult, Julie Lar...Ovarian Cancer Research Fund Alliance
This document discusses the developmental challenges faced by young adult cancer survivors. It begins by defining the adolescent and young adult (AYA) population and reviewing developmental theories relevant to AYAs. It then outlines key developmental tasks of AYAs, such as establishing independence and developing relationships. The document also examines the emotional needs of AYA cancer survivors and the psychological issues they may face due to the demands of cancer and its impact on normal development. It emphasizes the importance of resilience and provides strategies for AYA cancer survivors to build resilience through self-care, coping skills, and social support.Expert Roundtable, Michael Seiden, MD, PhD
This document discusses ovarian cancer research and clinical trials. It provides an overview of ovarian cancer subtypes and gene mutations associated with serous cancer. It also summarizes various drug targets and clinical trials being studied for ovarian cancer treatment, including PARP inhibitors, Akt inhibitors, angiogenesis inhibitors, monoclonal antibodies, immune therapies, vaccines, and CAR-T cells. Challenges in ovarian cancer research like intra-tumor variability and the complexity of genetics are discussed. The importance of patient participation in clinical trials to advance scientific progress is emphasized.
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This document outlines the process from diagnosis to follow-up care for ovarian cancer. It begins with an introduction and disclosure section. It then covers the diagnosis process, including symptoms, imaging, biopsy and surgery. Treatment options like surgery, chemotherapy, targeted therapy and clinical trials are discussed. The roles of the treatment team members are defined. Follow-up care including exams, imaging and survivorship are also summarized. Resources and questions from patients are addressed. Key terminology around histology, grade, stage and tumor markers is explained.
When Cancer Comes Back, Sarah Adams, MD
This document summarizes a presentation on recurrent ovarian cancer given by Dr. Sarah Adams. It discusses the likelihood of recurrence based on initial cancer stage, common symptoms of recurrence, methods for diagnosing recurrence including physical exam, CA125 levels, and imaging, and treatment options based on platinum sensitivity including surgery, chemotherapy regimens, targeted therapies, and clinical trials. It also describes a 2010 European study that found initiating treatment earlier based on a CA125 doubling led to longer treatment-free intervals and improved overall survival compared to delayed treatment until symptom recurrence.
Mello Abrams Lecture: Research in Ovarian Cancer, Where Are We Now?, Michael ...
Mello Abrams Lecture: Research in Ovarian Cancer, Where Are We Now?, Michael ...Ovarian Cancer Research Fund Alliance
The document discusses improving care for ovarian cancer patients. It outlines the "Triple Aim" of better care, better value, and better outcomes. It describes elements to improve patient care like navigation, survivorship care, and advance care planning. It discusses new payment models that incentivize high quality care while reducing costs, and challenges of implementing value-based care. Finally, it covers recent scientific advances in personalized medicine for ovarian cancer through genetic testing and targeted therapies.Cancer in the Workplace, Ann Hodges
This document summarizes legal protections and obligations for employees with cancer. It discusses the Family and Medical Leave Act (FMLA), Americans with Disabilities Act (ADA), disability benefits from Social Security, private plans, and state programs, health insurance through the Affordable Care Act and COBRA, gaps in coverage, practical strategies, and resources for legal assistance. Key legal protections provide unpaid and job-protected leave under FMLA and prohibit disability discrimination under ADA, which requires reasonable accommodation. However, many employees remain uncovered or face challenges obtaining benefits.
Your Advocacy at Work: The DoD Academy, Elizabeth Poole, PhD
- Mouse models and epidemiological studies suggest a role of chronic stress in tumor progression and cancer risk.
- In ovarian cancer patients, higher levels of stress are associated with higher levels of angiogenic and inflammatory markers, poorer quality of life, and worse survival.
- Data from the Nurses' Health Studies show associations between various measures of stress - like depression, anxiety, social isolation, and widowhood - and increased risk of ovarian cancer. Longer telomere length is associated with decreased risk.
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This document summarizes Dr. Karen McLean's research on targeting the tumor microenvironment in ovarian cancer. It discusses how signals from mesenchymal stem cells and estrogen in the microenvironment promote cancer growth and resistance to therapy. Experiments show that blocking the IL-6 and LIF cytokine signals from mesenchymal stem cells, in addition to blocking estrogen signals, significantly reduces cancer cell growth more than targeting either pathway alone. The goal is to identify biomarkers to predict which patients may benefit from anti-estrogen therapies and improve treatment outcomes by blocking multiple promoting signals in the tumor microenvironment.
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Clinical trials provide a way to test new cancer therapies and determine their benefits and risks compared to existing standard treatments. This presentation discusses when patients should consider clinical trials, what types of trials are available for ovarian cancer, and key points about targeted therapies and genomic profiling. It notes that clinical trials now mirror the treatment paradigm for ovarian cancer, with trials available at each line of treatment. Over 40 phase 2 and 3 ovarian cancer trials and hundreds of phase 1 solid tumor trials are currently recruiting. Genomic profiling of a patient's tumor may help match them to targeted therapies in clinical trials based on specific molecular alterations.Ovarian Cancer Research and Prevention, Andrew Berchuck, MD
The document discusses recent research on early detection of ovarian cancer, including findings from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Key points include:
- UKCTOCS found that multimodal screening (MMS) using CA125 and ultrasound was more sensitive (86%) than ultrasound alone (63%) for detecting early stage ovarian cancers, and led to fewer unnecessary surgeries.
- Mortality was reduced by 15-28% with MMS compared to no screening over 7-14 years of follow up. MMS also resulted in more cancers being diagnosed at early stages.
- Further analysis of UKCTOCS data is needed to better establish the benefits and
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Breakout: Side Effects of Cancer Treatment: Robert Morgan MD
This document summarizes the side effects of ovarian cancer treatment presented by Dr. Robert J. Morgan Jr. It discusses:
- Side effects of surgery depending on a woman's age, including immediate surgical menopause or menopausal symptoms.
- Menopausal symptoms like hot flashes, sleep issues, vaginal dryness, and mood changes.
- Treatment options for menopausal symptoms including hormones, lifestyle changes, and alternatives.
- Side effects of chemotherapy including nausea, fatigue, neuropathy, and myelosuppression. Ways to manage toxicities are discussed.
- Hormonal therapies and targeted agents used and their potential side effects.
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