This document provides an overview of current issues impacting brand safety. It discusses how third-party cookies are being deprecated due to privacy regulations like GDPR and CCPA. This could impact third-party measurement which is important for transparency. Other issues discussed include deepfakes threatening trust, the need for transparency, and concerns about being overly cautious with brand safety. Specific challenges are outlined for connected TV, digital out-of-home, location data, audio, and gaming environments. The document aims to assess potential future shifts and provide guidance on these evolving brand safety issues.