2. WHAT IS GOODPASTURE
SYNDROME?
• Goodpasture Syndrome is a very rare autoimmune disease that
affects the lungs and or kidneys.
• In Goodpasture Syndrome, the immune system makes
antibodies that attacks the kidneys and lungs.
• In a healthy immune system, antibodies are made to attack
diseases and viruses, in Goodpasture Syndrome it attacks
valuable body parts.

3. How Does Someone get this
disease?
 The main cause of the disease is unknown.
 Scientists believe the main cause of the disease is due to
exposure to certain chemicals.
 These chemicals include hydrocarbon solvents and the
weed killer, Paraquat.
 The disease may also be caused by the use of certain
drugs, such as cocaine, or by tobacco smoking.

4. What’s the importance of
Kidneys and Lungs?
• Kidneys are two small organs found in the back of a human
body.
• Kidneys are used to separate urea, mineral salts, toxins and other
wastes from blood. They also store water, salt and electrolytes in
the body.
• Lungs are the organs in the human body responsible for gas
exchange.
• They replace the carbon dioxide in your blood into oxygen. This
allows blood to pump into your heart without killing you.

6. How Is Goodpasture
Syndrome Treated?
• GoodPasture Syndrome is treated with various
immunosuppressive drugs. These drugs include
cyclophosphamide and corticosteroids (a type of steroid).
• A process by the name of plasmapheresis may also be
necessary to remove the harmful antibodies from the
blood.

7. After Effects of
GoodPasture Syndrome
• The initial disease of GoodPasture Syndrome may only
last about 2 weeks to 2 years, however its affects to the
body’s lungs and kidneys can be long-lasting.
• Bleeding in lungs caused by GoodPasture Syndrome can
be very serious and fatal in some cases, however it does not
usually lead to permanent lung damage.
• Kidneys however can have life-long damage. If your
kidneys fail, a process called dialysis is required to clean out
waste products and extra fluid from your body.

12. Interview
 I interviewed my father, Kenneth Cohen, an individual
who was diagnosed with Goodpasture Syndrome in 2007.
 Q: What does your weekly schedule look like while
dealing with this disease?
 A: I still work 5 days a week, however, there are a series
of complications in my life now. I have to go to Dialysis
every Monday, Wednesday and Thursday from 3- about
630. I take numerous medications every day in the
mornings, afternoons, and nights which help relieve
anxiety, restlessness, headaches, and help my body
function even with the lack of kidneys.

13. Interview (cont’d)
 Q: How has this disease impacted your personal life?
 A: I am unable to go out and do the things I used to do. I become
fatigued very easily and now suffer from high blood pressure. I am
encouraged to avoid situations that cause my blood pressure to increase
.
 Q: What has the transplant process been like?
 A: Obtaining a transplant is very difficult due to a number of factors.
For one, the kidney must match your body’s personal requirements (ie:
blood type, age, etc.) or else it will be rejected, thus causing further
complications. Also, there is a main list which can take over 15 years to
even be considered for a specific kidney or organ.

14. “A Father’s Gift of Life to
his 10 Year Old Son with
Rare Kidney Disease”
Non- Fiction Article

15. A FATHER has saved his 10-year-old son from the rare disease that was killing
him by donating one of his kidneys. Raphael Havard, who suffered total kidney
failure and needed 11 hours of dialysis every night, can now look forward to a
healthy future after his father Duane, 51, stepped forward to save him. Raphael,
from Bedford, had Goodpasture Syndrome, in which the body's immune system
creates antibodies that attack the lungs and kidneys. He fell ill in February last
year. Mr Havard and his wife Anna, 35, took him to the GP and he was
diagnosed with a stomach bug, then gastritis. Within days his condition
worsened and he was taken to hospital where staff, alarmed by test results,
consulted Great Ormond Street Children's Hospital. Raphael's creatinine level,
a way of measuring kidney function, was 1,044 micromoles per litre of blood,
when the average for a child is 30-57 micromoles. He initially spent six weeks at
Great Ormond Street, having three operations, 20 plasma exchanges and two
blood transfusions. His bedroom at home, kept to hospital level hygiene
standards, was equipped with a dialysis machine. But now, just over a year on,
the family's story with a happy ending is being told in a BBC documentary.
Mr Havard said he and his wife both offered to donate. "He's our only child --
it's just the immediate instinct you have. You would do anything for that child,
we both wanted to do it desperately." The surgery in November was followed
by an anxious six-week wait to see if it was a success, but now family life is
getting back to normal. Raphael went back to school in January and his father is
back at work.

16. Follow-Up
 To learn more about this topic, you can interact with any
type of doctor or surgeon.
 Or you can visit http://www.webmd.com/a-to-z-
guides/goodpasture-syndrome for an overview of this
disease, its effects, and treatments.

17. QUIZ TIME
 What organs does Goodpasture Syndrome key in on and
effect?
 A: The Kidneys and Lungs
 What influences a match for an organ transplant?
 A: Blood type, age, deceased or living organ, and waiting
list
 How can someone get this disease?
 A: Unknown….. BUT…. Possible causes include drugs,
chemicals, and tobacco smoke.

18. References
 "A father's gift of life to 10-year-old son with rare kidney disease." London Evening
Standard [London, England] 13 Mar. 2012: 9. Opposing Viewpoints In Context. Web.
10 May 2013.
 Salama, Alan D., Levy, Jeremy B., Lightstone, Liz., Pusey, Charles D.. "Goodpasture's
disease." Lancet 9285(2001):917. eLibrary. Web. 17 Apr. 2013.
 Ball, J., and Young, K.: "Pulmonary Manifestations of Goodpasture's Syndrome.
Antiglomerular Basement Membrane Disease and Related Disorders," Clinics in Chest
Medicine. 19(4):777-791. December 1998. Heltmark, T., et al.: "Characterization of
Anti-GBM Antibodies Involved in Goodpasture's Syndrome," Kidney International.
46(3):823-829, September 1994.
 "Goodpasture Syndrome: MedlinePlus Medical Encyclopedia." U.S National Library of
Medicine. U.S. National Library of Medicine, n.d. Web. 10 May 2013.
 "Goodpasture Syndrome Overview: Diagnosis, Symptoms, and Treatment." WebMD.
WebMD, n.d. Web. 10 May 2013.

19. Questions?