Glycogen Storage Diseases
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V.S.Rashmi Priyem graduated from Ultra's Best Dental Science College. She received her dental degree and is now licensed to practice dentistry. Rashmi's education qualifies her to provide quality dental care and treatment to patients.
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Scalenus Posterior
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Cervical Plexus
The cervical plexus is formed by the ventral rami of cervical nerves C1-C4. It lies deep to neck muscles and veins, and gives off cutaneous and muscular branches. Cutaneous branches include the lesser occipital, great auricular, transverse cervical, and supraclavicular nerves. Muscular branches supply neck muscles like the sternocleidomastoid and trapezius, as well as the diaphragm. The cervical plexus communicates with other nerves and the sympathetic trunk.
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In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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