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Gilbert syndrome
Epidemiology • Most common inherited disorder of bilirubin metabolism
Pathogenesis
• ↓ Hepatic UDP glucuronosyltransferase activity → ↓ conjugation
of bilirubin
Clinical findings
• Recurrent episodes of mild jaundice
• Provoked by stress (eg, febrile illness, fasting, dehydration,
vigorous exercise, menstruation, surgery)
Diagnosis
• ↑ Unconjugated bilirubin (ie, indirect hyperbilirubinemia)
• Normal CBC, blood smear, reticulocyte count
• Normal AST, ALT, alkaline phosphatase
Treatment • Benign; no treatment required

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Gilbert syndrome HY

  • 1. Gilbert syndrome Epidemiology • Most common inherited disorder of bilirubin metabolism Pathogenesis • ↓ Hepatic UDP glucuronosyltransferase activity → ↓ conjugation of bilirubin Clinical findings • Recurrent episodes of mild jaundice • Provoked by stress (eg, febrile illness, fasting, dehydration, vigorous exercise, menstruation, surgery) Diagnosis • ↑ Unconjugated bilirubin (ie, indirect hyperbilirubinemia) • Normal CBC, blood smear, reticulocyte count • Normal AST, ALT, alkaline phosphatase Treatment • Benign; no treatment required